Relationship between Metabolic Syndrome and Cigarette Smoking in the Japanese Population

Miyatake, Nobuyuki; Wada, Jun; Kawasaki, Yoshihisa; Nishii, Kenji; Makino, Hírofumi; Numata, Takeyuki

doi:10.2169/internalmedicine.45.1850

Cited by 63 publications

(47 citation statements)

References 18 publications

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“…Third, the smoking data was collected by binary criteria in this study so the effects of smoking on metabolic syndrome components might be underestimated [35] . In summary, fatty liver and smoking were closely related to insulin resistance [1][2][3][4][5][6][7][8][9][11][12][13][14]16,[21][22][23]25,32] , and our study provided evidence that fatty liver and smoking had a synergistic effect on metabolic syndrome and its components, especially for triglyceride and HDL-C levels. We suggested that smoking cessation would have the great benefit of reducing the risk of metabolic syndrome, especially for subjects with fatty liver.…”

Section: Discussionmentioning

confidence: 55%

“…Smoking, fatty liver and metabolic syndrome 5335 www.wjgnet.com and enhances cardiovascular risk factors such as elevated plasma triglycerides (TG) [16][17][18][19] , decreased high-density lipoprotein cholesterol (HDL-C) [16,20] and hyperglycemia [11] . Furthermore, several studies show that smoking is associated with metabolic abnormalities and increases the risk of metabolic syndrome [21][22][23][24] . Nakanishi et al [21] reported that subjects who habitually smoked tobacco had a 1.07-to 1.66-fold risk of developing metabolic syndrome compared to subjects who did not smoke, and the quantity of tobacco smoked had a dose-dependent relationship with the severity of metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic effect of fatty liver and smoking on metabolicsyndrome

Chiang¹,

Chang²,

Chen³

2009

WJG

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AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its components. METHODS:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005. A total of 3455 (1981 men and 1474 women) subjects were included in final analyses. Fatty liver was diagnosed using abdominal ultrasonography by trained gastroenterologists. The modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic syndrome. The associations between smoking, fatty liver and metabolic syndrome were analyzed using multiple logistic regression. RESULTS:Subjects with fatty liver, and who smoked tobacco, had the highest odds ratios (ORs) for high waist circumference [OR, 4.5 (95% CI: 3.3-6.1), P < 0.05], hypertriglyceridemia [OR, 8.1 (95% CI: 6.0-10.9), P < 0.05], low serum high-density lipoprotein cholesterol (HDL-C) [OR, 8.3 (95% CI: 6.1-11.3), P < 0.05], and metabolic syndrome [OR, 9.5 (95% CI: 6.7-13.4), P < 0.05] compared to subjects without fatty liver who did not smoke tobacco. We also found that the ORs for hypertriglyceridemia, low serum HDL-C, and metabolic syndrome for subjects with fatty liver who smoked tobacco had greater than the sum of the ORs for subjects with fatty liver who did not smoke plus those who did not have fatty liver and who did smoke.CONCLUSION: Fatty liver and smoking had a synergistic effect on metabolic syndrome and its components, especially for hypertriglyceridemia and low serum HDL-C.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Synergistic effect of fatty liver and smoking on metabolicsyndrome

Chiang¹,

Chang²,

Chen³

2009

WJG

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“…These findings may suggest important clinical implications. There are currently no reports showing that the modulation of adiponectin, resulting from the modification of smoking habits, affects the development of metabolic syndrome, atherosclerosis and cardiovascular disease; however, smoking habits are modifiable, so it is expected that smoking cessation can prevent future negative cardiometabolic outcomes by increasing the adiponectin levels [6][7][8][9] . Several biological reasons for the lower adiponectin levels by smoking are considered in the present review.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, meta-bolic syndrome has recently been given sociomedical attention due to its increasing prevalence and atherosclerotic burden 4,5) . Of note, smoking is reportedly associated with the development of metabolic syndrome, presumably via a pathway leading to the development of cardiovascular disease [6][7][8][9] . Metabolic syndrome is an obesity-related disorder, and various adipocytokines play crucial roles in the pathophysiology of metabolic syndrome 10) .…”

Section: Introductionmentioning

confidence: 99%

Adiponectin and Smoking Status: A Systematic Review

Kotani

Hazama

Hagimoto

et al. 2012

J Atheroscler Thromb

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Aim:Smoking and adiponectin are individually associated with cardiometabolic pathologies. The present systematic review was carried out in order to summarize the association between the smoking status and circulating adiponectin levels. Methods: Original articles, restricted to epidemiological studies (by a cross-sectional, case-control and cohort study design) and intervention studies for adult humans, were screened for the years 1995-2010. All of the research group members then selected the eligible literature and assessed the articles in a structured systematic review manner. Results: There were 11 key studies, which included 9 articles with a cross-sectional design and 2 articles with an intervention design. Most cross-sectional studies reported lower levels of adiponectin in current smokers than in non/never smokers and/or ex-smokers, while 2 studies reported a non-significant difference in adiponectin between male smokers and non-smokers. The two intervention studies, conducted in patients on 9-week bupropion treatment and 6-month non-pharmacological treatment, reported that smoking cessation increased the adiponectin levels. Conclusion: This review suggests that there is a decreased adiponectin level in current smokers and this reduction can be reversed by quitting smoking. More studies are required to confirm the findings and elucidate the biological mechanisms underlying the association between the smoking status and adiponectin levels.

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“…Since the exercise intensity at VT is not harmful to cardiovascular function, it can be safely applied to patients with myocardial infarction as an exercise prescription [4]. We have previously reported that aerobic exercise level was significantly lower in subjects with metabolic syndrome than that in subjects without the syndrome [5], and the prevalence of metabolic syndrome was significantly higher in subjects with cigarette smoking than that in subjects without cigarette smoking [6]. However, the relationship between cigarette smoking and aerobic exercise level defined by VT is not fully discussed.…”

Section: Introductionmentioning

confidence: 99%

Relation between cigarette smoking and ventilatory threshold in the Japanese

Miyatake

Numata

Nishii³

et al. 2010

Environ Health Prev Med

Self Cite

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The link between cigarette smoking and ventilatory threshold (VT) was investigated. We used data for 407 men and 418 women not taking medication. Habits of cigarette smoking were obtained through interviews by well-trained staff. The influence of cigarette smoking on oxygen uptake, work rate, and heart rate at VT was evaluated. Oxygen uptake at VT in women and work rate at VT in men with cigarette smoking were significantly lower than in subjects without cigarette smoking after adjusting for age. The differences of parameters at VT did not reach significant levels after adjusting for age and exercise habits in both sexes. However, in women without exercise habits, there was significant difference of oxygen uptake at VT between women with and without cigarette smoking after adjusting for age [cigarette smoking (?): 11.5 ± 1.8 ml/ kg/min, cigarette smoking (-): 12.4 ± 2.1 ml/kg/min, p = 0.0006]. The number of cigarettes smoked per day and the Brinkman Index were not clearly correlated with oxygen uptake at VT. A combination of promoting exercise habits and prohibiting cigarette smoking might be recommended for improving the aerobic exercise level, especially in women.

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Relationship between Metabolic Syndrome and Cigarette Smoking in the Japanese Population

Cited by 63 publications

References 18 publications

Synergistic effect of fatty liver and smoking on metabolicsyndrome

Synergistic effect of fatty liver and smoking on metabolicsyndrome

Adiponectin and Smoking Status: A Systematic Review

Relation between cigarette smoking and ventilatory threshold in the Japanese

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