Relationship between mean platelet volume and central serous chorioretinopathy

Dursun, Ayhan; Toker, Mustafa; Özeç, Ayşe Vural; Bozali, Erman; Kirboğa, Kadir; Dursun, Feyza; Erdoğan, Haydar; Topalkara, Ayşen; Arıcı, Mustafa Kemal

doi:10.1007/s10792-016-0237-0

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…The comparison of anti‐CNV effect between bevacizumab and ranibizumab is controversial. Further researches are needed to resolve the contradiction …”

Section: The Drug Treatment Of Cnvmentioning

confidence: 99%

Recent drug therapies for corneal neovascularization

Liu

Wang

et al. 2017

Chem Biol Drug Des

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Corneal neovascularization (CNV) is a common pathological change in ocular surface diseases. It is not only the factor that affects vision but also the main cause for corneal graft failure. Based on the mechanism of CNV, many achievements have been developed to suppress the formation of CNV. There are certain novel drugs such as aflibercept, gold nanoparticles, and netrins which provide us with new clues to treat CNV. However, we still need to develop more effective therapeutic drugs. It is of great significance to develop new effective drugs to suppress the occurrence of CNV. In this paper, recent drug therapies for CNV are reviewed. The electronic database (PubMed) is searched for relative basic research and randomized clinical trials that are published recently.

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“…The comparison of anti‐CNV effect between bevacizumab and ranibizumab is controversial. Further researches are needed to resolve the contradiction …”

Section: The Drug Treatment Of Cnvmentioning

confidence: 99%

Recent drug therapies for corneal neovascularization

Liu

Wang

et al. 2017

Chem Biol Drug Des

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“…Dursun et al assessed MPV in patients with CSCR. 29 Similarly, MPV value was found to be higher in CSCR patients than controls. In that study, CSCR patients were not stratified as acute or chronic.…”

Section: Discussionmentioning

confidence: 90%

“…To the best of our knowledge, in the literature, the only study assessing MPV in patients with CSCR was conducted by Dursun et al 29 However, there is no study assessing MPV and NLR in patients with CSCR in the literature. In this study, it was aimed to evaluate MPV and NLR values and their relationship with clinical findings in patients with CSCR.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil/lymphocyte ratio and mean platelet volume in central serous chorioretinopathy

Erol¹,

Balkarlı

Yucel³

et al. 2017

TCRM

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PurposeThis study aimed to evaluate mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) values and their relationship with clinical findings in patients with central serous chorioretinopathy (CSCR).MethodsOverall, 87 patients fulfilling inclusion criteria and 320 age- and sex-matched healthy individuals as controls were included in the study. The CSCR patients (n=87) were classified into 2 groups as acute CSCR (group 1, n=43) and chronic CSCR (group 2, n=44).ResultsIt was found that NLR (P<0.05) and C-reactive protein (CRP) (P<0.05) values were higher in acute CSCR group than the other groups. MPV value was found to be higher in chronic CSCR group than the other groups (P<0.001).ConclusionIt seems that neutrophils play a major role in acute CSCR while platelets are involved in progression to chronic CSCR. Larger, prospective studies are needed on this topic.

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“…[17][18][19] Similarly, increased MPV has been seen in patients with ankylosing spondylitis, hip osteoarthritis and central serous chorioretinopathy. [20][21][22] Conversely, lower MPV concentrations have been reported in patients with acute mania, acute pancreatitis and venous thromboembolism. [23][24][25] Moreover, Wang et al reported a relationship between decreased MPV and severe periodontitis, suggesting that MPV may be a useful inflammatory marker reflecting the periodontal disease.…”

Section: Discussionmentioning

confidence: 99%

Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity

Shi

et al. 2017

Ann Clin Biochem

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Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Therefore, our study aimed to evaluate the role of mean platelet volume concentrations in patients with Henoch-Schonlein purpura. Methods This study included 97 children with Henoch-Schonlein purpura and 120 healthy individuals as controls. Results Mean platelet volume concentrations were found to be significantly lower in Henoch-Schonlein purpura patients compared with healthy controls (8.1 ± 0.86 vs. 9.4 ± 0.81, P < 0.001). Similarly, significant negative correlations were observed between mean platelet volume and neutrophil count, platelet count and erythrocyte sedimentation rate in patients with Henoch-Schonlein purpura (r=-0.327, P = 0.001; r=-0.419, P < 0.001; r=-0.255, P = 0.012). Interestingly, mean platelet volume was significantly lower in the acute phase compared with the convalescent phase of Henoch-Schonlein purpura patients (7.8 ± 0.86 vs. 8.3 ± 0.77, P = 0.002). A cut-off value for mean platelet volume was 7.85 with area under the curve of 0.726 to identify acute phase vs. convalescent phase in patients with Henoch-Schonlein purpura. Mean platelet volume was independently associated with Henoch-Schonlein purpura in logistic regression analysis (odds ratio = 0.114, 95% confidence interval = 0.053-0.243, P < 0.001). Conclusions Our results suggest that mean platelet volume is inversely associated with disease in patients with Henoch-Schonlein purpura, and mean platelet volume may be a useful marker to identify active disease in Henoch-Schonlein purpura patients.

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Relationship between mean platelet volume and central serous chorioretinopathy

Cited by 6 publications

References 47 publications

Recent drug therapies for corneal neovascularization

Recent drug therapies for corneal neovascularization

Neutrophil/lymphocyte ratio and mean platelet volume in central serous chorioretinopathy

Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity

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