Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity

Shi, Xianbo; Li, Wenchao; Mo, Lijun; Li, Xiaohong; Luo, Yi; Qin, Liuqun; Yang, Zheng; Mo, Wuning

doi:10.1177/0004563217727015

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…Shi et al demonstrated that lower MPV values were observed in children with HSP than healthy individuals. 12 Makay et al, revealed that low MPV might be related to GI bleeding in HSP. 9 Some studies suggest that several inflammatory cytokines have been found to be increased in HSP patients and, these inflammatory cytokines are related to platelet activation.…”

Section: Discussionmentioning

confidence: 99%

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

et al. 2020

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Background: Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement. Methods: Children with HSP and healthy individuals as controls were included. Hemoglobin level, white blood cell count, platelet count, NLR, MPV erythrocyte sedimentation rate and C-reactive protein were evaluated. Results: There were 71 HSP children and 74 controls. NLR was significantly higher in HSP patients with gastrointestinal bleeding than without gastrointestinal bleeding (p < 0,001). The optimal cutoff value of NLR for predicting gastrointestinal bleeding was 2.05, with 93 % sensitivity and 62 % specificity. MPV was significantly higher in HSP patients with renal involvement than without renal involvement (p = 0,027). Conclusions: Blood NLR and MPV may be useful markers to identify gastrointestinal and renal involvement in HSP patients.

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Section: Discussionmentioning

confidence: 99%

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

et al. 2020

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“…Inflammatory mediators, such as interleukin‐6, which usually increases in acute or chronic conditions, may affect the bone marrow by changing the whole megakaryocytic platelet axis causing higher MPV levels 11,12 . MPV can give information on the course and prognosis in several pathological conditions, such as cardiovascular, respiratory, and rheumatological diseases 12–18 …”

Section: Introductionmentioning

confidence: 99%

Demographic, clinical, and laboratory features of COVID‐19 in children: The role of mean platelet volume in predicting hospitalization and severity

Özenen

Bal

Ümit

et al. 2021

Journal of Medical Virology

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There have been a limited number of studies on coronavirus disease 2019 in children. In this study, we aimed to investigate the demographic, clinical, and laboratory features of COVID-19 and to identify the role of mean platelet volume (MPV) in predicting the prognosis in children. A single-center retrospective study, including 251 confirmed and 65 suspected COVID-19 cases, was conducted between March 11, 2020, and December 11, 2020. In the confirmed COVID-19 group, 48 (19.1%) patients were asymptomatic, 183 (72.9%) mild, 16 (6.4%) moderate, 1 (0.4%) severe, and 3 were (1.2%) critically ill. Confirmed COVID-19 patients had significantly lower mean values of white blood cell (WBC), absolute neutrophil count, absolute lymphocyte count, platelet, and hemoglobin (p < .001). However, there was no significant difference in MPV levels between the two groups (p = .894). C-reactive protein (CRP), procalcitonin, fibrinogen, and NTpro-BNP mean values were significantly lower in confirmed COVID-19 cases than suspected cases (p < .001). A total of 55 (21.9%) patients required hospitalization due to COVID-19, and MPV, WBC, CRP, procalcitonin, D-dimer, and NT-pro-BNP were statistically higher in hospitalized patients than those in outpatients. The multivariate analysis of confirmed COVID-19 cases according to the severity of disease showed that lymphopenia and higher levels of fibrinogen significantly associated with severe clinical symptoms. Decision tree analysis showed that the most powerful predictor of hospitalization due to COVID-19 was the D-dimer (p < .001). MPV values are not associated with COVID-19 disease severity. However, MPV can be used with other parameters such as WBC, CRP, procalcitonin, D-dimer, and NT-pro-BNP to predict hospitalization.

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“…Studies on mean platelet volüme showing platelet function and activation have also increased in HSP patients in recent years. Xiang Shi et al [16] conducted a study with 97 patients with HSP and 120 healthy children as a control group. The mean platelet volüme was significantly lower in patients with HSP than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Impaired In-vitro Platelet Aggregation and Secretion Tests in Children with Henoch-schöenlein Purpura

Yazarli¹,

Pi²,

Dallar³

et al. 2021

Preprint

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Aim: This study aimed to investigate the in-vitro platelet aggregation and secretion tests in children patients with Henoch-schöenlein Purpura that recently referred to as Ig A vasculitis Methods: This is a cross-section study that included 55 patients with Henoch-schöenlein Purpura and 31 healthy children as a control group. Children who have a history of drug use, chronic diseases, and bleeding diseases were excluded from the study. Complete blood count, thrombocyte aggregation, and secretion tests were studied in both groups. These tests were re-evaluated in remission of the disease. Results: It was found that epinephrine-stimulated platelet aggregation and collagen, epinephrine, ristocetin, arachidonic acid, standard dose thrombin, and high dose thrombin-stimulated platelet secretion results were lower in the patients with Henoch-schöenlein Purpura compared to the healthy control group in the acute period (respectively P=0.014, 0,003; 0,003; 0,027; 0,034; 0,010; 0,049). When the values of patients with Henoch-schöenlein Purpura in the acute period and the remission of the disease were compared, collagen-stimulated platelet aggregation and epinephrine-stimulated platelet secretion values were found to be lower in patients with patients in the acute period (P= 0.016; 0.039) Conclusion: Impairment in vitro platelet aggregation and secretion tests in the patients with Henoch-schöenlein Purpura suggest that the tendency to bleeding in these patients may be due to platelet impairment function. Key Words: Henoch-schöenlein Purpura, platelet aggregation tests, platelet secretion tests, children, Ig A vasculitis. What’s already known about this topic? There is a tendency to bleeding in Henoch Shcöenlein Purpura patients, such as gastrointestinal bleeding, nonthrombocytopenic system purpura. What does this article add? It was found that impairment in-vitro platelet aggregation and secretion tests in Henoch Shcöenlein Purpura patients.

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Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity

Cited by 8 publications

References 28 publications

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

Demographic, clinical, and laboratory features of COVID‐19 in children: The role of mean platelet volume in predicting hospitalization and severity

Impaired In-vitro Platelet Aggregation and Secretion Tests in Children with Henoch-schöenlein Purpura

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