Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

Yakut, Halil İbrahim; Kurt, Tuba; Uncu, Nermin; Çaycı, Fatma Şemsa; Acar, Banu

doi:10.5546/aap.2020.eng.139

Cited by 15 publications

(12 citation statements)

References 13 publications

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“… 15 Other studies also reported that NLR was increased in HSP patients with organ involvement compared to patients without organ involvement. 16 , 17 In the present study, NLR was found to be a predictive index for renal involvement in HSP, while PLR was not found to be statistically different between HSP and HSPN.…”

Section: Discussioncontrasting

confidence: 43%

Predictive Value of Laboratory Indexes on Renal Involvement in Children with Henoch-Schönlein Purpura

Sun

et al. 2021

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Section: Discussioncontrasting

confidence: 43%

Predictive Value of Laboratory Indexes on Renal Involvement in Children with Henoch-Schönlein Purpura

Sun

et al. 2021

IJGM

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“…At disease onset, nephritis occurred from 20 to 80% of HSP patients, as observed herein (40%) [ 1 ]. According to previous studies, in 75–100% of patients, renal involvement develops within 4–6 weeks of the onset of the rash, and in almost all patients within the first 90 days [ 5 ]. In our patients, renal involvement was detected within 30 days from disease onset in 72% of patients, and within 6 months in 91%.…”

Section: Discussionmentioning

confidence: 99%

“…Henoch-Schönlein purpura (HSP), nowadays called immunoglobulin A (IgA) vasculitis, is the most common systemic vasculitis in pediatric age, with an annual incidence of 10–20 per 100,000 [ 1 , 2 , 3 , 4 , 5 ]. More than 90% of patients are younger than 10 years old and most HSP patients’ age is between 4 and 6 years [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Blood neutrophil-to-lymphocyte ratio (NLR) was investigated in many diseases as a marker of inflammation. NLR and platelet-to-lymphocyte ratio (PLR) are hypothesized to be potentially useful markers of developing renal involvement in early phase of disease, but few studies have reported this association [ 5 ]. In this retrospective study, the epidemiological, clinical and laboratory characteristics of our HSP patients were analyzed to determine the initial risk factors for HSPN development.…”

Section: Introductionmentioning

confidence: 99%

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Time of Onset and Risk Factors of Renal Involvement in Children with Henoch-Schönlein Purpura: Retrospective Study

et al. 2022

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Background: Henoch-Schönlein purpura (HSP) is a common systemic vasculitis in children, involving the skin, musculoskeletal system, gastrointestinal tract and kidneys. Some studies in children have shown possible risk factors linked with the development and severity of HSP Nephritis (HSPN). The aim of this study was to research predicting factors for the development of HSPN. Methods: We retrospectively evaluated 132 pediatric patients with HSP, according to EULAR/PRINTO/PRESS criteria. All patients were screened for HSPN by urinalysis. Finally, we compared demographic, clinical and laboratory data in HSP patients with and without nephritis. Results: The median age at HSP diagnosis [6.2 (2.6–17.5) vs. 5.5 (0.8–15.4) years, p = 0.03] and the incidence of abdominal pain (48 vs. 27%, p = 0.01) were significantly higher in HSPN patients. No differences were evidenced regarding gender, allergic diseases, skin recurrences, gastrointestinal involvement, musculoskeletal involvement, scrotal involvement, and laboratory data (white blood cell count, neutrophil count, lymphocyte count, platelet count, C-reactive protein, erythrocyte sedimentation rate, and blood concentration of IgA). Conclusions: The age at diagnosis and abdominal pain were independent risk factors for renal involvement in HSP patients. However, due to the retrospective nature of this study, further long-term and prospective studies will be necessary.

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“…NLR has been widely used to define the severity of inflammation 21 . Yakut et al (2020) 22 demonstrated that HSP patients with gastrointestinal bleeding had significantly higher NLR than those without gastrointestinal bleeding. Ozturk et al (2016) 23 also concluded that high NLR is related to gastrointestinal bleeding and renal involvement.…”

Section: Discussionmentioning

confidence: 99%

Renal biopsy in children with IgA vasculitis

et al. 2022

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Introduction Henoch-Schönlein purpura nephritis (HSN) is defined as Henoch-Schönlein purpura with kidney involvement, including hematuria and/or proteinuria. The aim of this study was to evaluate the data of HSN patients who underwent renal biopsy, and compare the main clinical and laboratory parameters that may affect renal biopsy findings, treatment protocols, and short- and long-term outcome of those patients. Methods Biopsies performed in 72 HSN patients between January 2007 to January 2017 were retrospectively evaluated. They were divided into two groups according to renal biopsy classification of the International Study of Kidney Disease in Children. Renal outcome, clinical and laboratory parameters, treatment protocols, and outcome were compared between groups. Short- and long-term follow-up of patients were evaluated. Results Of 72 patients, 47 were male (65.3%) and 44 (61.1%) were ≤10 years of age. Neutrophil-lymphocyte ratio was found higher in patients with scrotal involvement (p=0.042). Short-term unfavorable outcome was significantly higher in patients with scrotal involvement (p=0.038). Patients with hypertension and decreased creatinine clearance were found to have more unfavorable outcomes in long-term follow-up (p=0.029, p=0.040). Conclusion Cyclosporin-A and cyclophosphamide could be effective in steroid unresponsive HSN patients. Patients with scrotal involvement, decreased creatinine clearance, and hypertension should be closely monitored for sequelae of HSN.

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Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

Cited by 15 publications

References 13 publications

Predictive Value of Laboratory Indexes on Renal Involvement in Children with Henoch-Schönlein Purpura

Predictive Value of Laboratory Indexes on Renal Involvement in Children with Henoch-Schönlein Purpura

Time of Onset and Risk Factors of Renal Involvement in Children with Henoch-Schönlein Purpura: Retrospective Study

Renal biopsy in children with IgA vasculitis

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