Relationship Between MDM2 and p53 Alterations in Colorectal Cancer and Their Involvement and Prognostic Value in the Tunisian Population

Chaar, Ines; Amara, Sameh; Khiari, M.; Ounissi, Donia; Dhraif, Monia; Hamida, Abd E.M. Ben; Gharbi, Lassad; Mzabi, Sabeh; Bouraoui, Saâdia

doi:10.1097/pai.0b013e31825f4e20

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…When the genotype distribution found in the present study was compared to the data for different ethnic origins as demonstrated in Table 3, GG genotype frequency appeared to be similar to Japanese population 21 . GG genotype frequency in this study was higher than that reported in China 23 , Finland 24 , America 24,25 , Italy 20 , Spain 26 , Austria and Poland 27 , Germany 28 , Germany and Romania 29 and lower than in Tunisia 30 and Korea. Moreover, the maximum and minimum GG genotype frequencies recorded in different countries were 30.7% and 7.0%, respectively.…”

Section: Countrycontrasting

confidence: 82%

MDM2 SNP309 polymorphism in Turkish population

Taş

Sarı

Agbektaş

et al. 2017

Cumhuriyet Medical Journal

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Murine double minute 2 (MDM2) gene has a critical role on regulation of p53 tumor suppressor pathway. MDM2 is a major negative regulator of p53 function. MDM2 protein regulates p53 function through multiple independent pathways. The present study aims to determine the frequency of MDM2 gene SNP309 (rs2279744) polymorphism in the Turkish population. Method: This study included a total of 301 healthy Turkish individuals (159 females (53.0%) and 141 males (47.0%) between 2014 and 2016. The frequency of T309G MDM2 rs2279744 polymorphism was identified using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. Results: The mean age of the study population was 49,80±16,4 years (51,97±15,98 years in men and 47,58±16,82 years in women). Genotype frequencies for MDM2 rs2279744 polymorphism were found to be 17.9% TT, 55.2% TG, and 26.9% GG. Conclusions: The present study provides information on the allele and genotype frequency distribution of MDM2 gene rs2279744 polymorphism in the Turkish population, which can be used as a reference parameter for the investigation of susceptibility to various disorders, particularly cancer.

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Section: Countrycontrasting

confidence: 82%

MDM2 SNP309 polymorphism in Turkish population

Taş

Sarı

Agbektaş

et al. 2017

Cumhuriyet Medical Journal

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“…24,25 Accumulating evidence indicated that downregulation of MDM2 through various approaches resulted in repressing tumor growth and metastasis, [26][27][28] including CRC. 29,30 MAP4K4 is also involved in activation of c-Jun N-terminal kinase (JNK) pathway. 31 C-Jun, the substrate of JNK, induced expression by phosphorylation of JNK.…”

Section: Introductionmentioning

confidence: 99%

MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway

et al. 2015

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“…According to the exclusion criteria, 5 publications were excluded including 2 publications containing overlapping data [21,22], 1 for not presenting sufficient data for calculating OR and 95% CI [23], and 2 were meta-analysis [11,12]. Manual search of references cited in the eligible studies identified 1 additional article [24].…”

Section: Resultsmentioning

confidence: 99%

An Updated Meta-Analysis on the Association of MDM2 SNP309 Polymorphism with Colorectal Cancer Risk

et al. 2013

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BackgroundThe mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. The SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Studies investigating the association between MDM2 SNP309 polymorphism and colorectal cancer (CRC) risk reported conflicting results. We performed a meta-analysis of all available studies to explore the association of this polymorphism with CRC risk.MethodsAll studies published up to July 2013 on the association between MDM2 SNP309 polymorphism and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Chinese Biomedical Literature database (CBM) databases. The association between the MDM2 SNP309 polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs).ResultsA total of 14 case-control studies including 4460 CRC cases and 4828 controls were identified. We did not find a significant association between the MDM2 SNP309 polymorphism and CRC risk in all genetic models in overall population. However, in subgroup analysis by ethnicity, significant associations were found in Asians (TG vs. TT: OR = 1.197, 95% CI = 1.055–1.358, P=0.005; GG+TG vs. TT: OR = 1.246, 95% CI = 1.106–1.404, P=0.000) and Africans. When stratified by HWE in controls, significantly increased risk was also found among the studies consistent with HWE (TG vs. TT: OR = 1.166, 95% CI = 1.037–1.311, P= 0.010). In subgroup analysis according to p53 mutation status, and gender, no any significant association was detected.ConclusionsThe present meta-analysis suggests that the MDM2 is a candidate gene for CRC susceptibility. The MDM2 SNP309 polymorphism may be a risk factor for CRC in Asians.

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Relationship Between MDM2 and p53 Alterations in Colorectal Cancer and Their Involvement and Prognostic Value in the Tunisian Population

Abstract: In this work we wanted to highlight the role, which is becoming increasingly important, of MDM2. In fact, we conclude that the effects of MDM2 SNP309 may be considered a valuable prognostic marker to predict poor outcome for Tunisian patients with colorectal cancer.

Cited by 9 publications

References 36 publications

MDM2 SNP309 polymorphism in Turkish population

MDM2 SNP309 polymorphism in Turkish population

MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway

An Updated Meta-Analysis on the Association of MDM2 SNP309 Polymorphism with Colorectal Cancer Risk

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