Relationship Between Maternal Age and Aneuploidy in in vitro Fertilization Pregnancy Loss

Outcome of in vitro fertilization in women 45 years and older who use autologous oocytes

“…These patients need to be prepared for the high failure rate and disappointment that is seen with these losses. As we have previously reported, most of these losses can be expected to be chromosomal in origin (10).…”

“…Live-born delivery rates inversely correlate with maternal age. Furthermore, even after achieving a pregnancy through IVF-ET, the older patient is at a higher risk for miscarriage (7)(8)(9)(10).…”

Cytogenetic testing of anembryonic pregnancies compared to embryonic missed abortions

“…When a miscarriage occurs, patients are often concerned not only with the cause of the miscarriage but also with the risk of recurrence. The majority (50-76%) of these losses is due to embryonic aneuploidy [1][2][3][4][5][6][7][8][9]. Although not uniformly shown in all studies, some authors have found that women who miscarry genetically normal embryos have higher recurrence rates than those who miscarry aneuploid embryos [4,10,11].…”

Fetal cardiac activity at 4 weeks after in vitro fertilization predicts successful completion of the first trimester of pregnancy

“…However, in pregnancies resulting from IVF, not excluding women with a history of recurrent miscarriage, %25% of singleton clinical pregnancies are lost in the first trimester, even after detection of a fetal heartbeat (5)(6)(7). We decided to exclude from our analysis any couples with recurrent miscarriage (defined as R3 pregnancy losses), to control for the confounding effect of the higher risk of pregnancy loss in these couples.…”