Fetal cardiac activity at 4 weeks after in vitro fertilization predicts successful completion of the first trimester of pregnancy

Seungdamrong, Aimee; Purohit, Mamta; McCulloh, David H.; Howland, Richard D.; Colon, J; McGovern, Peter G.

doi:10.1016/j.fertnstert.2007.08.018

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…An interesting finding was that among women with SRM, the detection of fetal heart action by ultrasound in GW6 is no guarantee against subsequent miscarriage: 34% of the participants miscarried after heart action had been confirmed in GW6. This is in contrast to women without RM conceiving after in vitro fertilisation, in whom the detection of fetal heart action in GW6 resulted in a subsequent live birth rate of 87% …”

Section: Discussionmentioning

confidence: 75%

Intravenous immunoglobulin treatment for secondary recurrent miscarriage: a randomised, double‐blind, placebo‐controlled trial

Christiansen

Larsen

Egerup³

et al. 2014

BJOG

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Objective To determine whether infusions with intravenous immunoglobulin (IVIg) during early pregnancy increase live birth rate in women with secondary recurrent miscarriage compared with placebo.Design A single-centre, randomised, double-blind, placebocontrolled trial.Setting A tertiary centre for recurrent miscarriage in Copenhagen, Denmark.Population A group of 82 women with unexplained secondary recurrent miscarriage and at least four miscarriages.Methods Women were randomly assigned to repeated infusions with IVIg or placebo (albumin) from the time of positive pregnancy test to gestational week 15 or pregnancy loss.Main outcome measure Primary outcome was birth with neonatal survival in all randomised women. ResultsIn the intention-to-treat analyses, live birth rates were 23/ 42 (54.8%) in the IVIg and 20/40 (50.0%) in the placebo group, relative risk 1.11 (95% CI 0.70-1.74). In a per protocol analysis, almost identical results were found. The median gestational length at delivery was higher in the IVIg than the placebo group (282 versus 272 days, P = 0.02) but the mean birthweight was not significantly increased.Conclusions In this trial, which is the largest so far, IVIg did not increase the live birth rate in patients with secondary recurrent miscarriage and the treatment cannot be recommended in clinical practice.

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Section: Discussionmentioning

confidence: 75%

Intravenous immunoglobulin treatment for secondary recurrent miscarriage: a randomised, double‐blind, placebo‐controlled trial

Christiansen

Larsen

Egerup³

et al. 2014

BJOG

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“…For these women, anxiety about their baby's health often manifested itself in disrupted sleep, increased nightmares, and compulsive behaviors such as constant checking for vaginal bleeding. Although positive fetal cardiac activity at 6 weeks' gestation was found to be an excellent predictor of first-trimester outcomes in IVF pregnancy (Seungdamrong et al, 2008), only during certain milestones such as movement seen on ultrasound did this anxiety temporarily ease . Women in this study expressed angst about their anxiety, wishing for a more sense of ease so that they could enjoy the pregnancy which had taken so long to achieve.…”

Section: Clinician Implicationsmentioning

confidence: 97%

Pregnancy-Related Anxiety in Women Who Conceive Via In Vitro Fertilization: A Mixed Methods Approach

Stevenson¹,

Trotter²,

Bergh³

et al. 2016

J Perinat Educ

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The process of in vitro fertilization (IVF) causes anxiety, but it is unclear whether this anxiety continues into pregnancy and affects childbirth preparation. This study administered the pregnancy-related anxiety measure to 144 women during their second trimester. Anxiety scores were slightly higher among IVF compared to non-IVF pregnant women. Thirty-one participants provided narrative data about their pregnancy-specific anxiety. Themes emerged from qualitative analysis related to anxiety about the health of their babies, perception of maternal health and safety, and perception of their abilities to fulfill the role of mother. Because of their relationship with patients during pregnancy, nurses and perinatal educators play a critical role in identification of women with pregnancy-specific anxieties and providing relevant care to address these anxieties.

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“…Multiple studies have explored the prognostic value of markers of pregnancy outcome, most focusing on early transvaginal ultrasound findings (8)(9)(10)(11)(12)(13). In naturally conceived pregnancies, the detection of fetal cardiac motion (FCM) on ultrasound between 8 and 12 weeks of gestation is associated with a low miscarriage rate of 2% (14).…”

mentioning

confidence: 99%

“…Deaton et al (8) showed that the presence of a yolk sac between 22 and 32 days after ET was associated with the development of FCM in 94% of cases, whereas the absence of a yolk sac by 32 days after fertilization was associated with a 100% rate of spontaneous abortion. Fetal cardiac activity at 6 weeks' gestation has been shown to be an excellent predictor of first-trimester pregnancy outcome after IVF, although this study was limited by its exclusion of women with a history of recurrent pregnancy loss (9).…”

mentioning

confidence: 99%

Serum beta human chorionic gonadotropin levels can inform outcome counseling after in vitro fertilization

Lawler

Budrys

Rodgers

et al. 2011

Fertility and Sterility

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Fetal cardiac activity at 4 weeks after in vitro fertilization predicts successful completion of the first trimester of pregnancy

Cited by 12 publications

References 16 publications

Intravenous immunoglobulin treatment for secondary recurrent miscarriage: a randomised, double‐blind, placebo‐controlled trial

Intravenous immunoglobulin treatment for secondary recurrent miscarriage: a randomised, double‐blind, placebo‐controlled trial

Pregnancy-Related Anxiety in Women Who Conceive Via In Vitro Fertilization: A Mixed Methods Approach

Serum beta human chorionic gonadotropin levels can inform outcome counseling after in vitro fertilization

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