Relationship between Malocclusion and Heart Rate Variability Indices in Young Adults

Ekuni, Daisuke; Takeuchi, Noriko; Furuta, Michiko; Tomofuji, Takaaki; Morita, Manabu

doi:10.3414/me10-01-0045

Cited by 11 publications

(10 citation statements)

References 44 publications

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“…We also carried out HRV analysis and compared the ratio of LF/HF, an index of the sympathetic nervous activity [25], nHF, an index of the parasympathetic nervous activity, and SDNN, which is a measure of total autonomic instability [24,25,60], at 1 day before (baseline) and at 1, 7 and 14 days after BO treatment. The LF/HF ratio was significantly increased and nHF was significantly decreased, compared to the baseline at all time points after BO, as expected, because occlusal disharmony increases stress in humans [61,62] and in rats [6]. However, mean HR was unexpectedly reduced in BO mice, compared to the control baseline.…”

Section: Discussionsupporting

confidence: 79%

Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice

Yagisawa¹,

Suyama²,

Okita³

et al. 2020

PLoS ONE

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Occlusal disharmony leads to morphological changes in the hippocampus and osteopenia of the lumbar vertebra and long bones in mice, and causes stress. Various types of stress are associated with increased incidence of cardiovascular disease, but the relationship between occlusal disharmony and cardiovascular disease remain poorly understood. Therefore, in this work, we examined the effects of occlusal disharmony on cardiac homeostasis in bite-opening (BO) mice, in which a 0.7 mm space was introduced by cementing a suitable applicance onto the mandibular incisior. We first examined the effects of BO on the level of serum corticosterone, a key biomarker for stress, and on heart rate variability at 14 days after BO treatment, compared with baseline. BO treatment increased serum corticosterone levels by approximately 3.6-fold and the low frequency/high frequency ratio, an index of sympathetic nervous activity, was significantly increased by approximately 4-fold by the BO treatment. We then examined the effects of BO treatment on cardiac homeostasis in mice treated or not treated with the non-selective β-blocker propranolol for 2 weeks. Cardiac function was significantly decreased in the BO group compared to the control group, but propranolol ameliorated the dysfunction. Cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage were significantly increased in the BO group, but propranolol blocked these changes. The BO-induced cardiac dysfunction was associated with increased phospholamban phosphorylation at threonine-17 and serine-16, as well as inhibition of Akt/mTOR signaling and autophagic flux. These data suggest that occlusal disharmony might affect cardiac homeostasis via alteration of the autonomic nervous system.

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Section: Discussionsupporting

confidence: 79%

Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice

Yagisawa¹,

Suyama²,

Okita³

et al. 2020

PLoS ONE

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“…The HRV indices have been investigated to understand various conditions, including coronary artery disease, heart failure, hypertension, diabetes, chronic obstructive pulmonary disease, renal failure, epilepsy, depression, among others [4,5,10]. In dentistry, HRV has been associated with malocclusion [10], temporomandibular joint dysfunction [11], in dental surgery [12] and effects of sedatives [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…In dentistry, HRV has been associated with malocclusion [10], temporomandibular joint dysfunction [11], in dental surgery [12] and effects of sedatives [13,14]. Ekuni et al [10] evaluated the effects of malocclusion on the HRV indices. The authors found that malocclusion causes chronic stress that can affect the HRV indices.…”

Section: Discussionmentioning

confidence: 99%

Association between oral variables and heart rate variability

Santana¹,

Souza²,

Abreu³

et al. 2013

Int Arch Med

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The heart rate variability is a useful method to assess cardiac autonomic modulation in patients undergoing dental procedures, because knowledge of physiological conditions provides greater security to the professional as well as the possibility of a better plan treatment to patient benefit. The aim of our study was to describe the association between cardiac autonomic control and dental variables. We consulted the databases Medline, SciELO, Lilacs and Cochrane, using the terms “autonomic”, “dentistry”, “heart rate variability”, “cardiovascular physiology.” The selected studies indicated a strong relationship between dental variables and HRV. There was an association between malocclusion, TMD, dental procedures cirugia and low HRV. Thus, they become more studies that relate to HRV in dental science, especially in clinical practice.

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“…PRV was measured using a sphygmograph (TAS9 Pulse Analyzer Plus, YKC, Tokyo, Japan) for 15 min at 27 °C with subjects in the supine position and wearing light clothing. The frequency domain information was automatically analyzed with a fast Fourier transform [ 24 , 25 ]. This analysis involved 1000 samples, a 300-ms pulse interval resampling frequency, and a Hanning window function.…”

Section: Methodsmentioning

confidence: 99%

Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment

Nirengi

Amagasa

Wakui

et al. 2018

J Physiol Anthropol

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BackgroundBrown adipose tissue (BAT) is sympathetically activated and induces thermogenesis during cold exposure, thereby influencing energy expenditure and body fat levels. The very low frequency (VLF) components of pulse rate variability could be a form of thermogenic sympathetic nervous activity, but no clear relationship has yet been reported between VLF activity and BAT density. We therefore aimed to evaluate the association between them.MethodsWe enrolled 20 adults in winter and 20 matched adults in summer. We assessed BAT densities based on total hemoglobin concentrations ([total-Hb]) measured with near-infrared time-resolved spectroscopy. We calculated VLF activity from pulse rate variability measurements.ResultsBAT density ([total-Hb]; winter 70.5 ± 17.0 μM, summer 57.8 ± 18.3 μM) and VLF activity (winter 6.7 ± 0.8, summer 6.1 ± 0.9) were significantly higher in winter than in summer (P < 0.05). However, there was no significant correlation between VLF activity and BAT density in either season.ConclusionEach parameter exhibited seasonal variation, but we failed to observe any significant correlations.

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Relationship between Malocclusion and Heart Rate Variability Indices in Young Adults

Abstract: The data showed an association between malocclusion and lower HRV. Based on our results, orthodontic treatment might contribute not only to improvement of oral esthetic and functional problems but also to improvement of stress and HRV indices.

Cited by 11 publications

References 44 publications

Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice

Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice

Association between oral variables and heart rate variability

Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment

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