Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Abstract

Background: Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective: The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods: In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results: Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion: Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.

Insertion / Deletion Polymorphism of Angiotensin Converting Enzyme Gene Does Not Contribute to Chronic Kidney Disease in Palestine

“…ACE genotype distribution differs from one population to another or even from one year to another in the same population. In Palestine, the D/D genotype was the most frequent genotype as demonstrated by the present study and this result is also similar to other studies [8,12], as it was shown to be the most frequent genotype in Iraq [13], while the I/D genotype was the most frequent genotype in Turkey [14] and the UAE [6]. Some countries like Egypt [15,16] have an inconstant frequency for the genotypes, and this may be related to the sample size, the population of the study or the techniques used in the determination of ACE gene polymorphism.…”

“…In terms of the association with HTN, it was not deemed to be statistically significant, and this result concurs with [8] and [14] but disagrees with Alsafar et al (2015) [6]. D/D genotype…”

“…Some countries like Egypt [15,16] have an inconstant frequency for the genotypes, and this may be related to the sample size, the population of the study or the techniques used in the determination of ACE gene polymorphism. However, other countries the distribution of the genotypes is constant, such as Palestine [12] and Iraq [13], also in this study ACE alleles frequency compared to different studies, where D allele was more frequent in this study and other studies [6,[12][13][14], whereas the I allele had the highest frequency in another study [16].…”

Association Between Angiotensin Converting Enzyme Gene Insertion\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\Deletion Polymorphism and Coronary Heart Disease in Gaza Strip

“…The DD genotype and D allele may serve as the criteria for identifying patient groups which are at high risk for MI and CHD [56]. A studies conducted in Iraq [53], Algeria [45] and Lebanon [47] showed that there was statistically significant between ACE genotype among the study groups which differ from our findings, while there was good agreement between our results and the results that revealed from Turkish one [49]. No significant differences were detected in allele or genotype frequencies between patients and controls (p = 0.48).…”

Host Genetic Polymorphisms and Disease Severity in Pregnant Women with COVID-19 in Türkiye

“…There were no allele frequency differences between Turkish control women and women with COVID-19 for the ACE I/D. [28][29][30] The ACE2 gene is located on the X chromosome at the position Xp22. It contains 18 exons and shows close homology to ACE gene, since ACE2 discovered as a homolog of ACE.…”