Host Genetic Polymorphisms and Disease Severity in Pregnant Women with COVID-19 in Türkiye

Abstract

The coronavirus disease-2019 (COVID-19) is a pandemic caused by a single-stranded RNA virus belonging to the family of coronavirus. Over 192 million people were infected with COVID-19 and almost 2% of them died according to the World Health Organization COVID-19 dashboard and the virus continues to spread. COVID-19 primarily appears as lung disease and shows flu-like symptoms including cough, fever, fatigue, shortness of breath, and headache. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymp-tomatic or symptoms may range from pneumonia and respiratory failure. Various factors have been identified to elevate COVID-19 disease severity, such as age, male gender, and comorbidities including hypertension, cardiovascular disease, diabetes mellitus, and genetic susceptibility. 1 Pregnancy increases the risk of thromboembolic complications due to boost of clotting factors in the blood. COVID-19 can advance hypercoagulability risk in pregnant women further and create a higher risk for thromboembolism. 2 Variants on methylenete-