Relationship Between Iron Distribution in Deep Gray Matter Nuclei Measured by Quantitative Susceptibility Mapping and Motor Outcome After Deep Brain Stimulation in Patients With Parkinson's Disease

Abstract

Age, gender, disease duration, Hoehn and Yahr (H&Y) stage, and levodopa equivalent daily dosage (LEDD) of the PD patients were 582Volume 58, No. 2

Brain Iron Homeostasis and Mental Disorders

“…Brain cells, including neurons, astrocytes, oligodendrocytes and microglia, may take up Tf-Fe or NTBI via TfR1/divalent metal transporter 1 (DMT1) or DMT1 pathways, respectively; due to the presence of TfR1 and DMT1 on the membranes of these cells, they may also have additional, specific mechanisms of iron uptake [47]. It must be noted that different brain regions contain diverse iron contents [48,49], with relatively abundant levels in the basal ganglia region, subtantia nigra (SN), red nucleus and cerebellar dentate gyrus [50,51]. In contrast, iron is relatively low in the cerebral cortex, white matter and medulla oblongata [52,53].…”

Editorial for “Relationship Between Iron Distribution in Deep Gray Matter Nuclei Measured by Quantitative Susceptibility Mapping and Motor Outcome After Deep Brain Stimulation in Patients With Parkinson's Disease”

“…3 A successful treatment will reduce the patient's score on the Unified Parkinson's Disease Rating Scale (MDS-UPDRS III). 4 The article by Zhao et al 5 presents a prospective study of Parkinson's therapy via DBS of the STN, with 40 PD subjects evaluated. The study did not include a control group, since the intent was to measure the subjects' improvement under DBS and to determine whether the improvement correlates with texture features from presurgical quantitative susceptibility mapping (QSM) imaging, specifically with secondorder texture features derived from the gray level cooccurrence matrix (GLCM).…”