Brain Iron Homeostasis and Mental Disorders

Wu, Qiong; Ren, Qiuyang; Meng, Jingsi; Gao, Wei-Juan; Chang, Yan-Zhong

doi:10.3390/antiox12111997

Cited by 4 publications

(3 citation statements)

References 205 publications

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“…142 Iron has been shown to be critical for brain development and normal cognitive function, 143 Iron deficiency impairs the nervous system because iron plays an important role in myelin formation, neurotransmitter transmission, and metabolism in the brain, in addition to being involved in redox homeostasis. 144 Low ferritin levels in childhood have been reported to affect the development of the central nervous system, leading to behavioural abnormalities. 145 Therefore, given that children with ASD exhibit VC and iron deficiencies, we speculate that the association of VC with ASD may be due to the fact that VC acts as an antioxidant, reducing oxidative stress and neuroinflammation.…”

Section: Vitamin Cmentioning

confidence: 99%

The role and impact of abnormal vitamin levels in autism spectrum disorders

Cui,

Zhai,

Wang

et al. 2024

Food Funct.

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Section: Vitamin Cmentioning

confidence: 99%

The role and impact of abnormal vitamin levels in autism spectrum disorders

Cui,

Zhai,

Wang

et al. 2024

Food Funct.

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“…Iron accumulation leads to an inflammation cascade, which contributes to the development of neurodegenerative diseases [43]. Brain iron deposition is also involved in the progression of mental disorders, including depression, anxiety, schizophrenia, and post-traumatic stress disorder [44]. It seems that the location of iron deposition may influence the type of mental disorder; for example, iron deposition in the thalamus notably affects the severity of depression symptoms [45].…”

Section: Neurophysiology Of Thalassemia Patients and Its Association ...mentioning

confidence: 99%

Psychological Burden among Pediatric Thalassemia Major Patients in Indonesia: A Review

Sari,

Rahmartani,

Wirahmadi

et al. 2024

Thalassemia Reports

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Thalassemia a common hereditary blood disorder resulting in anemia. It is an important public health problem, with a high prevalence in Southeast Asia and Mediterranean countries, and preventable through screening programs. However, due to its chronic nature, permanent physical changes, troublesome complications, and lifelong treatment, pediatric patients with thalassemia major are more prone to mental disorders and cognitive impairment. Internalizing and externalizing problems are higher in pediatric patients with thalassemia. Children with β-thalassemia major exhibit lower IQ scores than healthy children. Neurophysiology and neuroimaging examinations have shown abnormal results in children with thalassemia. Co-morbidity with mental disorders increases the mortality, morbidity, and total healthcare costs of patients with thalassemia. Therefore, routine evaluation of mental health problems is recommended to accommodate the early detection and prompt treatment of mental disorders. A multidisciplinary approach for thalassemia patients and families should be delivered by providing appropriate medical care, psychosocial support, and good transition care to improve survival and well-being, assist good social integration and daily functioning, and cope with the stress of chronic disease.

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“…Brain iron disbalance is associated with a wide spectrum of neurological disorders, including stroke [1,2], mental disorders [3], and cancer [4], reflecting its comprehensive involvement in human brain physiology. Additionally, post-mortem examinations and patient MRI observations have revealed abnormal accumulation of brain iron in a group of neurodegenerative diseases, including, but not limited to, Alzheimer's disease (AD), Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) [5].…”

Section: Introduction and Objectives Of This Reviewmentioning

confidence: 99%

The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases

Lee,

Kovacs

2024

IJMS

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Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha-synuclein, and TDP-43. Accumulating evidence supports the contribution of iron in disease pathologies, but the delineation of its pathogenic role is yet challenged by the complex involvement of iron in multiple neurotoxicity mechanisms and evidence supporting a reciprocal influence between accumulation of iron and protein pathology. Here, we review the major proteinopathy-specific observations supporting four distinct hypotheses: (1) iron deposition is a consequence of protein pathology; (2) iron promotes protein pathology; (3) iron protects from or hinders protein pathology; and (4) deposition of iron and protein pathology contribute parallelly to pathogenesis. Iron is an essential element for physiological brain function, requiring a fine balance of its levels. Understanding of disease-related iron accumulation at a more intricate and systemic level is critical for advancements in iron chelation therapies.

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Brain Iron Homeostasis and Mental Disorders

Cited by 4 publications

References 205 publications

The role and impact of abnormal vitamin levels in autism spectrum disorders

The role and impact of abnormal vitamin levels in autism spectrum disorders

Psychological Burden among Pediatric Thalassemia Major Patients in Indonesia: A Review

The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases

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