The role and impact of abnormal vitamin levels in autism spectrum disorders

Cui, Jingjing; Zhai, Zidan; Wang, Shumin; Song, Xiaoyue; Qiu, Ting; Yu, Leilei; Zhai, Qixiao; Zhang, Heng

doi:10.1039/d3fo03735e

Food Funct.

2024

DOI: 10.1039/d3fo03735e

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The role and impact of abnormal vitamin levels in autism spectrum disorders

Jingjing Cui,

Zidan Zhai,

Shumin Wang

et al.

Abstract: This is a review of several vitamins (A, B, C, D, E, and K) that have been closely linked to the development of autism, exploring their mechanisms of action and significance in the prevention, mitigation, and treatment of autism.

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Impact of Maternal Environment and Inflammation on Fetal Neurodevelopment

Lubrano,

Parisi,

Cetin

2024

Antioxidants

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During intrauterine life, external stimuli including maternal nutrition, lifestyle, socioeconomic conditions, anxiety, stress, and air pollution can significantly impact fetal development. The human brain structures begin to form in the early weeks of gestation and continue to grow and mature throughout pregnancy. This review aims to assess, based on the latest research, the impact of environmental factors on fetal and neonatal brain development, showing that oxidative stress and inflammation are implied as a common factor for most of the stressors. Environmental insults can induce a maternal inflammatory state and modify nutrient supply to the fetus, possibly through epigenetic mechanisms, leading to significant consequences for brain morphogenesis and neurological outcomes. These risk factors are often synergic and mutually reinforcing. Fetal growth restriction and preterm birth represent paradigms of intrauterine reduced nutrient supply and inflammation, respectively. These mechanisms can lead to an increase in free radicals and, consequently, oxidative stress, with well-known adverse effects on the offspring’s neurodevelopment. Therefore, a healthy intrauterine environment is a critical factor in supporting normal fetal brain development. Hence, healthcare professionals and clinicians should implement effective interventions to prevent and reduce modifiable risk factors associated with an increased inflammatory state and decreased nutrient supply during pregnancy.

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Impact of Maternal Environment and Inflammation on Fetal Neurodevelopment

Lubrano,

Parisi,

Cetin

2024

Antioxidants

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The role and impact of abnormal vitamin levels in autism spectrum disorders

Abstract: This is a review of several vitamins (A, B, C, D, E, and K) that have been closely linked to the development of autism, exploring their mechanisms of action and significance in the prevention, mitigation, and treatment of autism.

Cited by 1 publication

References 179 publications

Impact of Maternal Environment and Inflammation on Fetal Neurodevelopment

Impact of Maternal Environment and Inflammation on Fetal Neurodevelopment

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