Relationship Between Intravenous Glucose Tolerance and the Fasting Blood Glucose Level in Healthy and in Diabetic Subjects

Moorhouse, J. A.; Grahame, Gordon R.; Rosen, Nicole

doi:10.1210/jcem-24-2-145

Cited by 81 publications

(20 citation statements)

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“…Our study shows that this is also true in subjects recruited from the general population, even when they are overwhelmingly non-obese and lack other diabetes risk factors. The K-value has been described as an integral measure of simultaneous changes in hepatic glucose output and peripheral glucose removal, both of which are modified by insulin release [32]. Indeed, it has been shown by Thorell [33], as well as by us [34], that the K-value is closely correlated with glucose-induced first-phase insulin secretion, while the correlation with insulin sensitivity is weaker [34].…”

Section: Discussionmentioning

confidence: 99%

K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years

et al. 2005

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Aims/hypothesis: Insulin resistance and insulin deficiency are proposed as risk factors for IGT and type 2 diabetes. We assessed the predictive value of initial parameters for the outcome of an OGTT performed 24.3±2.9 years later in an unselected healthy non-obese population. Methods: The K-value of an IVGTT was determined in 267 healthy subjects (mean±SD: age 31.0±12.0 years, BMI 21.8±2.8 kg/m 2 ). First-phase insulin response to a glucose infusion test was estimated as an incremental 5-or 10-min (ΔI5 or ΔI10) value, and as insulinogenic indices (ΔI5/ΔG5 or ΔI10/ΔG10) adjusted for insulin sensitivity determined by homeostasis model assessment for insulin resistance ([ΔI5/ΔG5]/HOMA-IR). Results: At followup, six subjects had type 2 diabetes and 47 had IGT; 214 retained normal glucose tolerance. Insulin sensitivity and early (30 min) insulin response decreased with decreasing outcome OGTT. Blood glucose (2 h) at OGTT correlated positively with initial age and BMI, and negatively with ΔI5/ΔG5, (ΔI5/ΔG5)/HOMA-IR and K-value. In multiple linear regression analysis, (ΔI5/ΔG5)/HOMA-IR, ΔI10, K-value, age, HOMA estimate of insulin secretion, and fasting plasma glucose were significantly associated with 2-h OGTT blood glucose. Similar results were obtained on comparing differences between subjects with normal and decreased (IGT+diabetes) glucose tolerance. Conclusions/interpretation: In 267 non-obese healthy subjects, initial K-value and first-phase insulin response to glucose adjusted for insulin sensitivity, but not insulin sensitivity itself, were strong predictors of the outcome of an OGTT performed 25 years later. Thus, in contrast to obese or other high-risk populations, in lean subjects, decreased beta cell function, but not insulin resistance itself, determines future glucose tolerance.

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Section: Discussionmentioning

confidence: 99%

K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years

et al. 2005

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“…An IV glucose challenge (500 mg/kg) was injected in all animals 6 h after cessation of anaesthesia, and arterial samples were taken at regular intervals for glucose and insulin estimations. The rate of fall of glucose concentration (K value) was calculated according to the method of Moorhouse et al [17] using glucose values between 10 and 30 min after the injection of the glucose challenge. The right kidney was then 0012-186X/82/0023/0343/$01.00 2.…”

Section: Methodsmentioning

confidence: 99%

Glucose and insulin changes following a renoportal shunt in streptozotocin diabetic rats with pancreatic islet isografts under the kidney capsule

McShane

Morris

1982

Diabetologia

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Summary. The effect on glucose metabolism of altering the site of the venous drainage of an isograft of isolated adult islets implanted beneath the renal capsule, from the systemic circulation to the portal circulation was determined in streptozotocininduced diabetic rats. Reversal of diabetes was accomplished by the transplantation of 1000-1200 isolated islets beneath the left kidney capsule. The rate of fall of the glucose concentration (as expressed by the K value) was found to be significantly decreased in transplanted animals (1.7 _+ 0.5%/rain; mean + SD) compared with normal animals (2.4 + 0.5%/rain). Draining the left renal vein into the portal circulation restored the K value to that of normal animals (2.5 + 0.4%). However the fasting glucose concentration was significantly higher and the basal insulin levels lower in both normal and transplanted rats with a renoportal shunt.

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“…Glucose, 0.5 g/kg body weight, was injected into an ex posed jugular vein and capillary blood samples were taken from the tail 0, 4, 12, 45 and 90 min after the glucose injection. K-values were calculated according to the method of Moorhouse et al [9].…”

Section: Methodsmentioning

confidence: 99%

Metabolic Response to Isologous Transplantation of Small Numbers of Isolated Islets of Langerhans in the Rat

Henriksson¹,

Bergmark²,

G³

1977

Eur Surg Res

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Pancreatic islets from adult donors were transplanted intraportally into 32 inbred, adult AGUS rats with streptozotocin diabetes. The islets were isolated with collagenase and counted individually. A relationship between the number of islets transplanted and the metabolic response could be demonstrated. Transplantation of less than 200 islets did not change the diabetic state. Rats receiving 200–220 improved, while recipients of 240–800 islets all exhibited normal values of blood glucose, plasma insulin, urine volume and urine glucose. The glucose tolerance, however, remained abnormal in all animals.

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Relationship Between Intravenous Glucose Tolerance and the Fasting Blood Glucose Level in Healthy and in Diabetic Subjects

Cited by 81 publications

References 0 publications

K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years

K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years

Glucose and insulin changes following a renoportal shunt in streptozotocin diabetic rats with pancreatic islet isografts under the kidney capsule

Metabolic Response to Isologous Transplantation of Small Numbers of Isolated Islets of Langerhans in the Rat

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