Relationship between insulin-like growth factor-1 and radiographic disease in patients with primary osteoarthritis: a systematic review

Abstract

Observational data showed no association between serum IGF-1 and occurrence of radiographic OA (moderate level of evidence), and a positive relationship between IGF-1 gene polymorphisms and radiographic OA (moderate level of evidence); however the confounding effect of BMI was insufficiently addressed. Future well-designed prospective studies should further elaborate the role of the complex GH/IGF-1 system in primary OA.

What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review

“…A qualitative review was performed instead. Strengths of the current approach are that two independent readers scored all the articles, that criteria for evaluation of the quality were in line with those of previous studies,6 7 and that predefined and stringent qualitative levels of evidence8 were used to summarise the data (strong evidence was defined as ≥75% of the HQ studies reporting an effect in the same direction). With this approach, we tried to optimise the accuracy of this systematic qualitative literature review.…”

“…The quality of each included paper was reviewed by two reviewers independently (JABvN and AHMvdHvM) using a maximum of 15 criteria (see online supplementary table S1), which were based on previous systematic reviews in the field of musculoskeletal disorders 6 7. The criteria were adapted for our research question of symptom duration.…”

MTHFRGene C677T Mutation andACEGene I/D Polymorphism in Turkish Patients with Osteoarthritis

“…Besides ACE gene, different gene polymorphisms were found associated with osteoarthritis. Honsawek et al investigated MMP-3-1612 5A/6A gene polymorphism with knee osteoarthritis in Thai population and indicated that the -1612 5A/6A polymorphism genotypes of MMP-3 gene promoter do not play a role in the development of osteoarthritis in the Thai population [2]. In a recent study Kostopoulo et al performed a genetic association analysis using a cohort of 1,410 Greek osteoarthritis patients and healthy controls The results that are statistically significant are typed in bold.…”

“…Despite the increase in molecular knowledge accrued during the past years, the exact pathogenesis of the destructive process remains unknown. Osteoarthritis is caused by genetic and environmental factors and is considered a multifactorial disease in which age, body mass index, hormonal and local biomechanical factors together with genetic predisposition play a role [2]. The genetics of OA is complex and is not completely understood, and to assess the validity of reported genetic associations, the best strategy is to reproduce those associations in independent cohorts and analysis of a relatively large number of candidate genes [1].…”

Osteoarthritis year 2012 in review: biomarkers

“…The authors conclude that sCOMP is elevated in patients with knee OA and is sensitive to OA disease progression and future research studies with a higher level of evidence should be conducted to investigate the use of this biomarker as an indicator for OA development and progression Madry et al, 2012 71 The aim of this systematic review was to highlight the molecular basis and histopathological features of early OA Special emphasis is placed on early changes in subchondral bone and other structures of the joint, such as the menisci, the synovial membrane, the joint capsule, ligaments, muscles and the infrapatellar fat pad Claessen et al, 2012 72 In this paper the authors conducted a systematic review of reported associations between circulating insulin-like growth factor-1 (IGF-1) and/or IGF-1 gene polymorphisms and radiographic OA No association was found between serum IGF-1 and the occurrence of radiographic OA (moderate level of evidence), and a positive relationship between IGF-1 gene polymorphisms and radiographic OA (moderate level of evidence); however the confounding effect of BMI was insufficiently addressed The authors propose that future well-designed prospective studies should further elaborate the role of the complex GH/IGF-1 system in primary OA Gharbi et al, 2011 73 The aim of this elegant review was to gather most of the available information relating to proteomic techniques and their applications to OA research Mobasheri 2011 74 This perspective article discusses the relevance and potential of proteomics for studying age-related musculoskeletal diseases such as OA and reviews the contributions of key investigators in the field 25 also focused on adipokines by investigating adiponectin levels in plasma and synovial fluids of female patients with knee OA. Adiponectin is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with anti-diabetic, anti-atherogenic and anti-inflammatory activities.…”