2013
DOI: 10.1155/2013/658654
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MTHFRGene C677T Mutation andACEGene I/D Polymorphism in Turkish Patients with Osteoarthritis

Abstract: Osteoarthritis is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. In recent years, numerous genetic factors have been identified and implicated in osteoarthritis. The aim of the current study was to examine the influence of methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation and angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) variations on the risk of osteoarthritis.Genomic DNA is obtained from 42… Show more

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Cited by 12 publications
(13 citation statements)
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References 22 publications
(58 reference statements)
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“…Poornima et al [11] observed that I/D polymorphism was associated with increased risk of OA in an Indian population. Similar results were also obtained in two Turkish studies [8,9]. They [8,9] both suggested that DD genotype of the ACE gene I/D polymorphism increased the risk of knee OA in Turkish populations.…”
Section: Discussionsupporting
confidence: 85%
“…Poornima et al [11] observed that I/D polymorphism was associated with increased risk of OA in an Indian population. Similar results were also obtained in two Turkish studies [8,9]. They [8,9] both suggested that DD genotype of the ACE gene I/D polymorphism increased the risk of knee OA in Turkish populations.…”
Section: Discussionsupporting
confidence: 85%
“…Only a limited number of studies have investigated the link between OA and the ACE I/D polymorphism [ 36 40 ]. In reports by Bayram et al (2011) and Inanir et al (2013), the DD genotype of the ACE gene I/D polymorphism was associated with knee OA in a Turkish study population [ 38 , 39 ]. Poornima et al (2015) observed the same phenomenon in an Asian Indian population [ 40 ].…”
Section: Introductionmentioning
confidence: 96%
“…Contrast-enhanced computed tomography scanning was performed to confirm the clinical suspicion of major or symptomatic cerebral, pulmonary, or intra-abdominal embolism. [17] …”
Section: Methodsmentioning
confidence: 99%
“…DNA samples were then subjected to polymerase chain reaction assays (Hot Master Mix Taq, 5 Prime, Milan, Italy) with primers (Biofab Research, Milan, Italy) specific for the genetic regions of interest, as previously described. [17] To detect the C677T SNP in the MTHFR gene, PCR products were digested with restriction endonucleases (Biofab Research, Milan, Italy) and subsequently run on 2% agarose gel electrophoresis (Carlo Erba Reagenti, Milan, Italy).…”
Section: Methodsmentioning
confidence: 99%