Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis

Lin, Chin; Hc, Chen; Fang, Wen‐Hui; Wang, Chih‐Chien; Peng, Yi‐Jen; Lee, Herng‐Sheng; Chang, Hung; Chu, Chi‐Ming; Huang, Guo-Shu; Chen, Wei-Teing; Tsai, Yu-Jui; Lin, Hong-Ling; Lin, Fu-Huang; Su, Sui-Lung

doi:10.1371/journal.pone.0161754

Cited by 6 publications

(17 citation statements)

References 78 publications

(80 reference statements)

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“…They [8,9] both suggested that DD genotype of the ACE gene I/D polymorphism increased the risk of knee OA in Turkish populations. Due to the conflicting findings, Lin et al [10] conducted a case–control study and meta-analysis to validate the association of I/D polymorphism with OA risk. They did not find any significant association between I/D polymorphism and knee OA in the case–control study and meta-analysis [10].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the conflicting findings, Lin et al [10] conducted a case–control study and meta-analysis to validate the association of I/D polymorphism with OA risk. They did not find any significant association between I/D polymorphism and knee OA in the case–control study and meta-analysis [10]. It was noteworthy that they regarded the Turkish populations as Arabians.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the meta-analysis by Lin et al [10] actually found a significant difference in the dominant model [OR: 1.72 (95% CI: 1.02 ± 2.90)], indicating that DD/ID genotype carriers had an increased risk for OA [10]. However, Lin et al [10] regarded it as negative finding. Two previous meta-analyses investigated the association between this SNP and OA risk.…”

Section: Discussionmentioning

confidence: 99%

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Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population

Chen

Lai

et al. 2019

Bioscience Reports

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Osteoarthritis (OA) is a degenerative joint disease characterized by joint destruction with cartilage loss and occasional gross derangement of joint integrity. In recent years, several studies have reported the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and knee OA. However, the results were conflicting. To determine the association between ACE gene I/D polymorphism and knee OA, we conducted a hospital-based case–control study with 282 knee OA cases and 316 controls to investigate the association between ACE gene I/D polymorphism and knee OA susceptibility in a Chinese Han population. The present study found that DD genotype or D allele carriers of ACE gene I/D polymorphism increased the risk of knee OA. Stratification analyses of sex, age, and body mass index (BMI) showed significant associations amongst the groups of females, ≥55 years, and abnormal BMI. In addition, the present study made analysis between ACE I/D polymorphism and some clinical features of OA, and found DD genotype of I/D polymorphism was associated with arthralgia. Furthermore, we undertook a meta-analysis together with the present study between this single nucleotide polymorphism (SNP) and knee OA risk. This meta-analysis found that ACE gene I/D polymorphism was associated with increased risk for OA. Stratification analysis of ethnicity in this meta-analysis indicated that I/D polymorphism increased the risk of knee OA amongst the Asians and Caucasians. In conclusion, this case–control study and meta-analysis suggest that ACE gene I/D polymorphism is associated with increased risk for knee OA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population

Chen

Lai

et al. 2019

Bioscience Reports

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“… 12 Nonetheless, the association between angiotensin-converting enzyme and KOA remains controversial. 19 …”

Section: Introductionmentioning

confidence: 99%

Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression

Calvo

Sánchez-Herraéz

Casis

et al. 2020

Bone & Joint Research

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Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease burden and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade ≥ 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopeptidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP). Results Synovial fluid peptidase activity varied significantly as a function of clinical signs, with differences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001) with knee effusion. Further, patients with the greatest functional impairment had significantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020), and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the renin-angiotensin system. A binary logistic regression model showed that PSA was protective (p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012). Conclusion These results suggest synovial fluid peptidase activity could play a role as a measure of disease burden and predictive biomarker of progression in KOA. Cite this article: Bone Joint Res 2020;9(11):789–797.

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“…2,3 However, the polymorphisms of several genes, such as angiotensin-converting enzyme, have been found to be unrelated to the susceptibility to knee OA. 4 A disintegrin and metalloproteinase 12 (ADAM12), the gene of which has been identified as a candidate gene for knee OA, plays role ADAM12 Polymorphisms in Knee Osteoarthritis in proteolysis, cellular interactions, and signal transduction. 5 After Valdes et al 6 published a study on the association of ADAM12 polymorphisms with knee OA, several studies were conducted at other centers.…”

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confidence: 99%

Association of Single Nucleotide Polymorphisms in a Disintegrin and Metalloproteinase 12 Gene With Susceptibility to Knee Osteoarthritis: A Meta-Analysis

Jung

Song

Kim³

et al. 2019

Arch Rheumatol

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Objectives: This study aims to investigate the association between a disintegrin and metalloproteinase 12 polymorphisms and susceptibility to knee osteoarthritis (OA) through a meta-analysis involving only studies that present original data. Materials and methods: A meta-analysis was performed on the association between a disintegrin and metalloproteinase 12 rs3740199, rs1871054, rs1278279 and rs1044122 polymorphisms and knee OA. An electronic search of all relevant studies published up to January 2017 was conducted using MEDLINE and EMBASE. The study included six case-control studies including 2,966 patients (850 males, 2,116 females) with knee OA and 4,901 controls (2,286 males, 2,615 females). Results: No significant association was found between the rs3740199, rs1278279, and rs1044122 polymorphisms and knee OA when all studies were pooled into the meta-analysis. However, a significant association was found between the rs1871054 polymorphism and the knee OA risk (allele contrast: odds ratio (OR)=1.42, 95% confidence interval (CI)=1.02-1.98, p=0.04; dominant: OR=1.36, 95% CI=1.02-1.82, p=0.04; recessive: OR=1.83, 95% CI=1.14-2.94, p=0.01; and addictive model: OR=1.85, 95% CI=1.06-3.23, p=0.03). In the subgroup analysis, a significant association was found between the recessive (OR=0.44, 95% CI=0.21-0.93, p=0.03) and addictive model (OR=0.29, 95% CI=0.12-0.69, p<0.01) in the male group. Conclusion: Our meta-analysis suggests that the rs1871054 polymorphism is associated with susceptibility to knee OA and that the GG genotype of rs3740199 was associated with knee OA in the male group. Additional well-designed studies are required to confirm these results. Citation:Jung JH, Song GG, Kim JH, Choi SJ. Association of single nucleotide polymorphisms in a disintegrin and metalloproteinase 12 gene with susceptibility to knee osteoarthritis: A meta-analysis. Arch Rheumatol 2019;34(1):62-70.

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Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis

Cited by 6 publications

References 78 publications

Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population

Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population

Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression

Association of Single Nucleotide Polymorphisms in a Disintegrin and Metalloproteinase 12 Gene With Susceptibility to Knee Osteoarthritis: A Meta-Analysis

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