Relationship between insulin and hypogonadism in men with metabolic syndrome

Caldas, Amanda D. A.; Porto, Adriana Lofrano Alves; Motta, Luíz Augusto Casulari Roxo da; Casulari, Luíz Augusto

doi:10.1590/s0004-27302009000800015

Cited by 14 publications

(11 citation statements)

References 58 publications

(101 reference statements)

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“…MS is a combination of disorders, including obesity, that can increase the risk of developing cardiovascular disease and diabetes [ 26 , 27 ]. It is largely known that components of MS induce reproductive axis disorders [ 27 ], though this strong link remains still unclear [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome

Oliva

Minutolo

Lippa

et al. 2016

International Journal of Endocrinology

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This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility.

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Section: Discussionmentioning

confidence: 99%

Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome

Oliva

Minutolo

Lippa

et al. 2016

International Journal of Endocrinology

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“…They have also determined that these hormones had protective effects against MS development. Caldas et al (36) reported an increase in both insulin resistance index (HOMA-R) and index that measures pancreatic beta cell function (HOMA-β) in hypogonadic patients with MS. We also found significantly lower SHBG levels in patients with MS and inverse correlation of SHBG with insulin, HOMA-R, BMI, WC. Previously, low SHBG levels were described in individuals with MS and were associated with insulin resistance, carbohydrate intolerance and central obesity (37).…”

Section: Discussionmentioning

confidence: 99%

Late-Onset Hypogonadism in Male Patients Over 60 Years of Age with Metabolic Syndrome

Kara¹,

Çelik²,

Kadıoğlu³

et al. 2013

Tjem

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Purpose: The aim of the study was to determine serum androgen levels and the frequency of late-onset hypogonadism (LOH) in patients over 60 years of age with metabolic syndrome (MS) and its correlation with parameters of MS. Material and Method: Men over 60 years of age who were diagnosed with MS according to the Adult Treatment Panel III (ATP III) criteria in the internal medicine outpatient clinics at Cerrahpasa Medical School (n=30) and healthy controls (n=30) were included in the study. Total testosterone and sex hormone binding globulin (SHBG) levels were analysed. Bioavailable and free testosterone levels were calculated. The participants filled up the Beck Depression Inventory (BDI) and Aging Male Symptoms (AMS) questionnaire forms themselves without any help of the physician. Results: LOH rates were 30% and 13.3% in the MS group and healthy control group, respectively (p=0.11). Serum total testosterone and SHBG levels were significantly lower in the MS group compared to controls (p=0.004 and p=0.003, respectively). A negative correlation was found between total testosterone and MS components. BDI and AMS questionnaire scores in the two groups were not significantly different.Discussion: Serum total testosterone and SHBG levels were lower in the MS group, and inversely proportional to this, insulin resistance and intensity of MS components were increased. Turk Jem 2013; 17: 22-

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“…Authors indicate that studies in women and elderly people are needed to find the best cut-off points for the entire population. Caldas et al 11 described the relationship between insulin and hypogonadism in men with metabolic syndrome and concluded that hypogonadism was associated with insulin resistance and may be a marker of metabolic abnormalities. Ferreira et al 12 described the effects of metformin on blood pressure and glucose metabolism in monosodium glutamate–induced obese, spontaneously hypertensive rats.…”

Section: Methodsmentioning

confidence: 99%

Metabolic and infectious pathologies in Brazilian medical literature: a review

Rocha-e-Silva¹

2010

Clinics

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OBJECTIVE: This review of original reports on metabolic and infectious diseases that were recently published in Brazilian journals is designed to inform the readership of CLINICS about their content.METHODS: I conducted a search in PubMed for original research articles (clinical or basic research) recently published (2008)(2009) by Brazilian medical and biological periodicals. Papers on metabolic pathologies were retrieved by searching for appropriate keywords such as metabolic syndrome and obesity. Papers on infectious disease were obtained by entering 15 different keywords for the most commonly occurring pathologies. Review articles, editorials, letters to the editor, and case reports were manually excluded. Selected titles were then categorized into appropriate sub-categories. RESULTS:This search produced a total of 123 articles, which filtered down to 72 articles after eliminating editorials, review articles, letters to the Editor and case reports.

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Relationship between insulin and hypogonadism in men with metabolic syndrome

Cited by 14 publications

References 58 publications

Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome

Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome

Late-Onset Hypogonadism in Male Patients Over 60 Years of Age with Metabolic Syndrome

Metabolic and infectious pathologies in Brazilian medical literature: a review

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