Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue

Niu, Xinjie; Wang, Zuoren; Wu, Shengli; Geng, Zhimin; Zhang, Yunfeng; Qing, Xing-Lei

doi:10.3748/wjg.v10.i5.725

Cited by 19 publications

(16 citation statements)

References 31 publications

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“…Kong [6,9,16,21,22,27]. Conversely, Ropponen et al and Puhakka et al reported that patients with tumors showing high expressions of iNOS and other NOS izozymes had better survival rates in colorectal and non-small cell lung carcinomas [25,29].…”

Section: Discussionmentioning

confidence: 98%

Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: an immunohistochemical study of 151 cases

et al. 2005

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The role of calcium independent inducible nitric oxide synthase (iNOS) in breast carcinoma is controversial, and the implications of iNOS expression on prognosis are not known. In this study, we aimed to investigate the significance of immunohistochemical iNOS expression in 100 invasive ductal carcinomas. In addition, 11 normal breast tissues, 20 cases of usual ductal hyperplasias (UDHs) and 20 fibroadenomas were included. We found that 78% of malignant and 75% of benign cases showed iNOS immunoreactivity. However, the intensity and the quantity of iNOS expression were significantly higher in the cancer group when compared with benign breasts (P<0.001), suggesting a role of iNOS in breast carcinogenesis. We were unable to show a correlation between iNOS expression and tumor grade, axillary lymph node status, and estrogen receptor expression. In 50 axilla negative cases having 5--12 years follow-up, disease free survival (DFS) rate was significantly lower in cases showing strong iNOS expression (P=0.05). As strong iNOS expression was correlated with short DFS, we concluded that further studies would be necessary to elucidate if iNOS expression might be a useful prognostic marker in breast carcinoma, especially in the axilla negative group.

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Section: Discussionmentioning

confidence: 98%

Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: an immunohistochemical study of 151 cases

et al. 2005

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“…[24] Analysis of the relationship between angiogenesis and iNOS in primary gallbladder carcinomas has shown that the degree of malignancy is significantly affiliated with the expression level of iNOS. [25] In breast cancer, NO • is shown to decrease aggressiveness of breast tumor cells by inhibiting cell motility and reinforcing cell adhesion, ultimately hindering the cell’s metastatic characteristics. [26] While NO • has been clinically connected to a poor cancer prognosis, not all the effects of NO • are clear and may be impacted by dose or organs involved.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide in cancer metastasis

Cheng¹,

Wang²,

Mollica³

et al. 2014

Cancer Letters

156

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COX-2, cyclooxygenase; CXCR4, CXC chemokine receptor 4; ECM, extracellular matrix; ELAM-1, endothelial leukocyte adhesion molecule 1; eNOS, endothelial nitric oxide synthase; GC, guanylyl cyclase; HIF-1, hypoxia-inducible factor-1; HUVECs, human umbilical vascular endothelial cells; IL-33, cytokine interleukin-33; iNOS, inducible nitric oxide synthase; MAPK, mitogen-activated protein kinase; MMP, matrix metalloproteinase; nNOS, neuronal nitric oxide synthase; NO•, nitric oxide; NO•-NSAIDs, nitric oxide-releasing non-steroidal anti-inflammatory drugs; NOS, nitric oxide synthase; PCNA, proliferating cell nuclear antigen; PKC, protein kinase C; QUER, quercetin; TPA, 12-O-tetradecanoylphorbol 13-acetate; t-PTER, trans-pterostilbene; VEGF-C, vascular endothelial growth factor-C

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“…Inducible nitric oxide synthase expression has been detected immunohistochemically in the human GB with acute cholecystitis or GB tumors. Few reports have been published on iNOS expression in normal GB tissue and, in pathological conditions, previous studies have focused on epithelial cells 14–16 …”

Section: Introductionmentioning

confidence: 99%

Effect of ursodeoxycholic acid on inflammatory infiltrate in gallbladder muscle of cholesterol gallstone patients

Carotti

Guarino

Cicala

et al. 2010

Neurogastroenterology Motil

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An inflammatory monocyte/macrophage, mast cell and granulocyte infiltrate is present in the GB muscle layer of GS patients. Ursodeoxycholic acid decreases macrophages, degranulated mast cells and COX-2 expression. These results suggest that monocytes/macrophages and degranulating mast cells contribute to muscle cell dysfunction in cholesterol GS patients and support the anti-inflammatory effect of UDCA.

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Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue

Abstract: Angiogenesis of PGBC is significantly related to the biological behaviors of PGBC. The expression of iNOS is related to the biological behaviors of PGBC. The detection of MVD and the expression of iNOS in PGBC can be used as parameters to determine the degree of malignancy and prognosis.

Cited by 19 publications

References 31 publications

Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: an immunohistochemical study of 151 cases

Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: an immunohistochemical study of 151 cases

Nitric oxide in cancer metastasis

Effect of ursodeoxycholic acid on inflammatory infiltrate in gallbladder muscle of cholesterol gallstone patients

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