Relationship between indocyanine green test and technetium-99m galactosyl serum albumin scintigraphy in patients scheduled for hepatectomy: Clinical evaluation and patient outcome

Nanashima, Atsushi

doi:10.1016/j.hepres.2003.11.010

Cited by 64 publications

(99 citation statements)

References 28 publications

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“…This test is based on the fact that asialoglycoprotein receptors on hepatocytes reflect functional liver cells [15] and are not influenced by vascular shunt or obstructive jaundice [16,17]. We confirmed previously that the results of 99m Tc-GSA scintigraphy reflected impairment of background liver [11]. However, the range of the Nanashima A et al, Page 4 liver uptake ratio (LHL15) was narrow, and therefore, it was sometimes difficult to decide on the extent of hepatectomy [11].…”

Section: Introductionsupporting

confidence: 86%

“…We confirmed previously that the results of 99m Tc-GSA scintigraphy reflected impairment of background liver [11]. However, the range of the Nanashima A et al, Page 4 liver uptake ratio (LHL15) was narrow, and therefore, it was sometimes difficult to decide on the extent of hepatectomy [11]. Therefore, 99m Tc-GSA liver scintigraphy remains experimental in nature and has not yet replaced the ICGR15 test.…”

Section: Introductionsupporting

confidence: 84%

“…As described above, the results of 99m-Tc GSA liver scintigraphy did not Nanashima A et al, Page 11 seem to be affected by biliary obstruction [11,12], and therefore, a more reliable estimation of liver functional reserve would be achieved. However, we decided that estimating the converted ICGR15 using only this parameter was problematic based on the availability of several other reliable liver function parameters.…”

Section: Discussionmentioning

confidence: 82%

“…To measure ICGR15, indocyanine green (ICG) was injected intravenously at a dose of 0.5 mg/kg body weight with the 15-minute retention rate measured by a photopiece applied to the fingertip (RK-1000, Sumitomo Electric, Tokyo, Japan) without blood sampling [7,8,11]. Peripheral blood samples were also collected before meals for analysis of hyaluronic acid (HA), a marker of hepatic fibrosis and endothelial cell function in hepatic sinusoids [18].…”

Section: Laboratory Testsmentioning

confidence: 99%

“…We have applied the latter formula to plan the extent of hepatic resection, and the estimated liver volume for resection by computed tomography (CT) was compared to the permitted volume [7,8]. Many investigators have also used the ICGR15 as the most reliable test for hepatic functional reserve before hepatectomy [3,9,10], but in cases of obstructive biliary diseases or vascular shunt of hepatic circulation, the results of ICG might be worse than the true functional reserve [11,12]. Furthermore, some patients are allergic to indocyanine.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prediction of Indocyanine Green Retention Rate at 15 Minutes by Correlated Liver Function Parameters before Hepatectomy

Nanashima

Abo

Tobinaga

et al. 2011

Journal of Surgical Research

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Section: Introductionsupporting

confidence: 86%

Section: Introductionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 82%

Section: Laboratory Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prediction of Indocyanine Green Retention Rate at 15 Minutes by Correlated Liver Function Parameters before Hepatectomy

Nanashima

Abo

Tobinaga

et al. 2011

Journal of Surgical Research

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A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow–derived cells

Matsuda

Takami

Sasaki

et al. 2017

Hepatology Communications

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We have been developing a therapy for liver cirrhosis using cultured autologous bone marrow–derived mesenchymal stem cells (BMSCs). Before human clinical trials can be considered, the safety and efficacy of BMSC infusion in medium to large animals must be confirmed; thus, we developed a canine liver fibrosis model. A small amount of bone marrow fluid was aspirated from the canine humerus to assess the characteristics of BMSCs. We implanted a venous catheter in the stomach and a subcutaneous infusion port in the back of the neck of each canine. Repeated injection of CCl4 through the catheter was performed to induce liver cirrhosis. After 10 weeks of CCl4 injection, eight canines were equally divided into two groups: no cell infusion (control group) and autologous BMSC infusion through the peripheral vein (BMSC group). A variety of assays were carried out before and 4 weeks after the infusion. The area of liver fibrosis stained with sirius red was significantly reduced in the BMSC group 4 weeks after BMSC infusion, consistent with a significantly shortened half‐life of indocyanine green and improved liver function. Conclusion: We established a useful canine liver fibrosis model and confirmed that cultured autologous BMSC infusion improved liver fibrosis without adverse effects. (Hepatology Communications 2017;1:691–703)

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Level of total bilirubin in the bile of the future remnant liver of patients with obstructive jaundice undergoing hepatectomy predicts postoperative liver failure

Uemura

Higuchi

Yazawa

et al. 2020

J Hepato Biliary Pancreat

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Background We investigated whether the daily level of total bilirubin in the bile (LTB) excreted from the future remnant liver (FRL) can predict post‐hepatectomy liver failure (PHLF) in patients with obstructive jaundice undergoing hepatectomy. Methods Seventy‐four patients who underwent biliary drainage and collection of bile juice from the FRL before undergoing right hepatectomy or right/left trisectionectomy with bile duct resection were included. The LTB from the FRL (mg/d) was calculated as the volume of the bile (dL) per day multiplied by the density of total bilirubin in the bile (mg/dL). We compared patients' characteristics with or without PHLF, which was defined as the total serum bilirubin level remaining >10 mg/dL after postoperative day 10. Then, pre‐ and intraoperative factors related to PHLF were examined. Results PHLF was observed in six patients. LTB was significantly lower in the PHLF group. The LTB cut‐off value for predicting PHLF, as determined using the receiver operating characteristic curve, was 56 mg/d. On multivariate analysis, LTB was found to be an independent risk factor for PHLF (P = .01, OR 35.88). Conclusions LTB may be a potential functional assessment in jaundiced patients before right hepatectomy and right/left trisectionectomy.

show abstract

Relationship between indocyanine green test and technetium-99m galactosyl serum albumin scintigraphy in patients scheduled for hepatectomy: Clinical evaluation and patient outcome

Cited by 64 publications

References 28 publications

Prediction of Indocyanine Green Retention Rate at 15 Minutes by Correlated Liver Function Parameters before Hepatectomy

Prediction of Indocyanine Green Retention Rate at 15 Minutes by Correlated Liver Function Parameters before Hepatectomy

A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow–derived cells

Level of total bilirubin in the bile of the future remnant liver of patients with obstructive jaundice undergoing hepatectomy predicts postoperative liver failure

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