Prediction of Indocyanine Green Retention Rate at 15 Minutes by Correlated Liver Function Parameters before Hepatectomy

Nanashima, Atsushi; Abo, Takafumi; Tobinaga, Syuuichi; Nonaka, Takashi; Fukuoka, Hidetoshi; Hidaka, Shigekazu; Takeshita, Hiroaki; Sawai, Terumitsu; Yasutake, Toru; Nagayasu, Takeshi; Kudo, Takashi

doi:10.1016/j.jss.2011.04.034

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…The exact interaction between ICG and bilirubin transport carriers has yet to be elucidated . As a result, a low measured ICG elimination should be interpreted with caution in patients with obstructive jaundice .…”

Section: Liver Function Monitoring Using Icgmentioning

confidence: 99%

“…Finally, in patients with biliary obstruction, a decreased ICGR15 value may be found, possibly falsely suggesting impaired liver function . In these patients, the pre‐operative ICGR15 value should be interpreted with caution, and should not be used to justify withholding intended curative surgery.…”

Section: Peri‐operative Point‐of‐care Monitoring Using Icg Kinetics Amentioning

confidence: 99%

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Green light for liver function monitoring using indocyanine green? An overview of current clinical applications

et al. 2014

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SummaryThe dye indocyanine green is familiar to anaesthetists, and has been studied for more than half a century for cardiovascular and hepatic function monitoring. It is still, however, not yet in routine clinical use in anaesthesia and critical care, at least in Europe. This review is intended to provide a critical analysis of the available evidence concerning the indications for clinical measurement of indocyanine green elimination as a diagnostic and prognostic tool in two areas: its role in peri-operative liver function monitoring during major hepatic resection and liver transplantation; and its role in critically ill patients on the intensive care unit, where it is used for prediction of mortality, and for assessment of the severity of acute liver failure or that of intra-abdominal hypertension. Although numerous studies have demonstrated that indocyanine green elimination measurements in these patient populations can provide diagnostic or prognostic information to the clinician, 'hard' evidence -i.e. high-quality prospective randomised controlled trials -is lacking, and therefore it is not yet time to give a green light for use of indocyanine green in routine clinical practice.

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Section: Liver Function Monitoring Using Icgmentioning

confidence: 99%

Section: Peri‐operative Point‐of‐care Monitoring Using Icg Kinetics Amentioning

confidence: 99%

Green light for liver function monitoring using indocyanine green? An overview of current clinical applications

et al. 2014

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“…It is important to evaluate hepatic reserve prior to hepatic resection, and the permissible extent of resection is considered on the basis of presence or absence of ascites, jaundice and the indocyanine green (ICG) retention rate at 15 min when determining the type of resection procedure 5 . If necessary, technetium‐99 m diethylenetriamine pentaacetic acid galactosyl human serum albumin single photon emission computed tomography (CT) is used to evaluate patients who cannot be adequately evaluated by means of an ICG load test 6,7 …”

Section: Hepatic Resectionmentioning

confidence: 99%

“…5 If necessary, technetium-99m diethylenetriamine pentaacetic acid galactosyl human serum albumin single photon emission computed tomography (CT) is used to evaluate patients who cannot be adequately evaluated by means of an ICG load test. 6,7 According to the report of the 18th follow-up survey of primary liver cancer in Japan, hepatic resection was performed in 31.7% of all cases of HCC, with operative mortality of 1.4% (Fig. 2).…”

Section: Hepatic Resectionmentioning

confidence: 99%

Treatment strategies for hepatocellular carcinoma in Japan

Yamashita

Kaneko

2012

Hepatology Research

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The main methods of treatment for hepatocellular carcinoma (HCC) in Japan are hepatic resection, radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE). Meticulous follow up is then undertaken to check for recurrence, which is treated using repeated RFA or TACE. Hepatic arterial infusion chemotherapy has been introduced as treatment for advanced HCC, and the molecular-targeted drug sorafenib is also now available. Rigorous medical care using these treatment methods and early diagnosis mean that the prognosis for HCC in Japan is the best in the world. This paper reviews the treatment strategies for HCC in Japan.

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“…In previous studies, indocyanine green, which was the main material for ICG-hyaluronic acid mixture, was already used for medical purposes. For example, the indocyanine green retention rate at 15 min (ICGR15) is a useful marker of liver function in deciding on the extent of hepatectomy (13). In addition, Mok et al reported that Indocyanine green encapsulated hyaluronic acid nanogels were used for highly selective detection of speci c cancers and lymph nodes (14).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Indocyanine green- hyaluronic acid mixture (LuminoMarkTM) for Localization in Patients with Non-palpable Breast Lesions: A Multi-center Open-label Parallel Phase-2 Clinical trial

kim

Choi

Ryu

et al. 2020

Preprint

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Backgrounds With increasing screening for breast cancer, non-palpable breast lesions are detected more frequently. A preoperative localization is very important for a minimal but accurate excision of a non-palpable breast lesion. The purpose of this study was to evaluate the efficacy and safety of indocyanine green(ICG)-hyaluronic acid mixture injection as a novel material for localization. Methods We performed prospective clinical trial with female patients who underwent surgery for non-palpable breast lesion. 44 patients were sequentially assigned to the control group(localization with activated charcoal), test group 1(ICG-hyaluronic acid mixture 0.1ml), or test group 2(ICG-hyaluronic acid mixture 0.2ml) by 1:1:1 ratio. Results Most were over 40 years old, and there were no differences between three groups in age distribution. According to the pathologic results, fibroadenoma accounted for the largest share (38.6%, 17/44) and malignancy accounted for 11.4% (5/44). The marking rate on both breast lesions and excised specimens was over 86% in all groups, and there was no difference. However, skin pigmentation was only in the control group and the accuracy of resection (the greatest length in cm of the excised specimen divided by the greatest length in cm on the pre-operation ultrasound image, the value closer to 1 meant resection as much as the size on ultrasound image) was different significantly. The average was 3.7(range 1.2-13.3) in control group and 2.2 (1.0-4.2) in test 1 group and 2.1(1.0-4.2) in test 2 group. Conclusion ICG-hyaluronic acid mixture injection was superior to activated charcoal for localization in patients with non-palpable breast lesions.

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Prediction of Indocyanine Green Retention Rate at 15 Minutes by Correlated Liver Function Parameters before Hepatectomy

Abstract: Background. Indocyanine green retention rate at 15 minutes (ICGR15) is a useful marker

Cited by 15 publications

References 23 publications

Green light for liver function monitoring using indocyanine green? An overview of current clinical applications

Green light for liver function monitoring using indocyanine green? An overview of current clinical applications

Treatment strategies for hepatocellular carcinoma in Japan

The Efficacy and Safety of Indocyanine green- hyaluronic acid mixture (LuminoMarkTM) for Localization in Patients with Non-palpable Breast Lesions: A Multi-center Open-label Parallel Phase-2 Clinical trial

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