Relationship between IL-6 gene polymorphism rs1800796 and IL-6 serum level with thyroid Hormones in a sample of Iraqi celiac disease patients.

Abstract

Celiac disease (CD) is an autoimmune human leukocyte antigen HLA–linked enteropathy that develops upon ingesting a gluten-containing diet, with diarrhea, malabsorption, and weight loss as a major presentation. The disease is closely linked to a number of extra-intestinal disorders, especially endocrine diseases. This study aimed to find the Relationship between IL-6 gene polymorphism rs1800796 and IL-6 serum level with thyroid Hormones in a sample of Iraqi celiac disease patients. The study includes one hundred subjects of Iraqi people in Baghdad (20-60 years) who were divided into two groups; the first group included patients, and the second group control; DNA was extracted, then the Genotyping polymorphism (rs1800796) of the IL-6 gene was done by RT-PCR. The CC genotype showed a higher frequency in the control, while the GG genotype showed a higher frequency in the patients. Keywords: celiac disease (CD), genetic polymorphism IL-6gene, thyroid stimulation hormone.