Relationship between IgG₁ and IgG₄ antibodies to foods and the development of IgE antibodies to inhalant allergens. II. Increased levels of IgG antibodies to foods in children who subsequently develop IgE antibodies to inhalant allergens

Abstract

In the present investigation we have tested the hypothesis that children with a high IgG antibody response to foods have an increased risk of developing IgE antibodies to inhalant allergens. Sera from 106 children with an increased risk of developing IgE-mediated allergy were analysed. During the follow-up, in 54 of these children IgE antibodies to inhalant allergens appeared. A positive/negative IgG1 and IgG4 anti-food score was determined as described previously: sera from age-clustered unselected children were tested for the levels of IgG1 and IgG4 antibodies to common foods. For each IgG RAST and each age group, the 75-percentile was chosen as cut-off value. Each antibody level was thus converted into a positive (higher than the 75-percentile of the age group) or negative value. The number of positive tests was used as the score. High-risk children with a high IgG1 anti-food score more often developed inhalant-specific IgE antibodies than high-risk children with low IgG1 titres: 50% of the children with a high IgG1 anti-food score developed IgE antibodies to grass pollen. Fifty per cent of the children with a high and 14% of the children with a low IgG1 anti-food score developed IgE antibodies to cat dander. For the prediction of the development of IgE anti-mite (house dust mite), the IgG4 anti-food scores appeared less useful than the IgG1 anti-food scores; 46% of the IgG4 high responders versus 22% of the IgG4 low responders acquired IgE anti-mite, whereas for IgG1 these percentages were 73 and 19, respectively.

Prebiotic‐supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high‐risk infants: a randomized controlled trial

“…Children who were sensitized 21 or asthmatic 22 at 5 years had higher hen's egg‐specific IgG1 in early life. In addition, high‐risk infants with high food‐specific IgG1 were more likely to develop inhalant‐specific IgE, compared with subjects with low food‐specific IgG1 21, 23, 24. These findings suggest that raised food‐specific IgG1 could represent a predictive biomarker for future allergic disease, in high‐risk infants.…”

IgG and IgG 4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort

“…Accordingly, it has been previously proposed that high levels of IgG to some allergens early in life might predict the development of IgE sensitization later in life. 20,21,38 Therefore this area of investigation is very complex, and further studies are now needed to define how default and preatopic IgG responses can be better discriminated.…”

The Potent lgG4-lnducing Antigen in Banana Is a Mannose-Binding Lectin, <i>BanLec-</i><i>I</i>

“…A group of sera were col lected from children under the age of 7 years with suspected atopy. These children participated in the study performed by Calkhoven et al [3], The sera were obtained after informed consent of the parents. For most subjects, no information was available on the dietary history' with respect to banana.…”

“…During an investigation of the antibody response to a broad panel of ingested foods [2,3], we found that the IgG antibody response to banana extract was much stronger than expected on the basis of quantities commonly in gested. This was particularly the case for lgG4 antibodies and much less so for IgGl or IgA antibodies.…”