Prebiotic‐supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high‐risk infants: a randomized controlled trial

Boyle, Robert; Tang, Mimi L.K.; Chiang, Wen Chin; Chua, Mei Chien; Ismail, Intan Hakimah; Nauta, Alma J.; Hourihane, Jonathan; Smith, Peter; Gold, Michael; Ziegler, John B.; Peake, Jane; Quinn, Patrick; Rao, Rajeshwar; Brown, Nick; Rijnierse, Anneke; Garssen, Johan; Warner, John O.

doi:10.1111/all.12848

Cited by 92 publications

(80 citation statements)

References 25 publications

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“…As indicated before, in addition to TCR activation, costimulation and cytokine signalling play an important role in the generation of Tregs. 4 In conclusion, this study demonstrated for the first time that a specific pHP contains functional human T cell epitopes. Previously, we have shown that pre-or synbiotics may play an important role in creating the right environment for this predisposition towards Tregs.…”

Section: Hla-drb1 Allelementioning

confidence: 58%

“…1 Failure to induce oral tolerance to food proteins may result in food allergy. 4 In this study, after 6 months of intervention, increased percentages of CD4 + CD25 high Foxp3 high regulatory T cells (Tregs) and 2,3 In a recent clinical trial the preventive effect of a prebiotic supplemented partially hydrolysed whey-based infant formula (pHP) on the development of eczema in infants with increased risk of developing allergic diseases was investigated.…”

Section: Introductionmentioning

confidence: 96%

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Identification of peptides with tolerogenic potential in a hydrolysed whey‐based infant formula

Gouw

Meulenbroek

et al. 2018

Clin Experimental Allergy

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Section: Hla-drb1 Allelementioning

confidence: 58%

Section: Introductionmentioning

confidence: 96%

Identification of peptides with tolerogenic potential in a hydrolysed whey‐based infant formula

Gouw

Meulenbroek

et al. 2018

Clin Experimental Allergy

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“…At 12 months, there was no difference in AD in the infants fed with study formula (07/347; 30.8%) compared to the infants fed with CMF (112/370; 30.3%; OR 0.99, 95% CI 0.71-1.37; p = 0.94). pHF-OS did not change most immune markers including total/specific IgE; however, pHF-OS reduced cow's milkspecific IgG1 ( p < 0.0001) and increased T reg cell and plasmacytoid dendritic cell percentages [81] .…”

Section: Prebioticsmentioning

confidence: 77%

Mechanisms of Tolerance Induction

Nowak‐Węgrzyn¹,

Chatchatee²

2017

Ann Nutr Metab

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Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure. An addendum to the NIAID food allergy guidelines recommends introduction of peanut into the diet of 4- to 6-month-old infants with severe eczema or egg allergy as an effective strategy to prevent peanut allergy. Strategies aimed at restoring the skin barrier are currently explored as an alternative approach of prevention of eczema and allergic sensitization. Manipulation of the diet via supplementation with probiotics and prebiotics to restore the healthy gut microbiota represents another potential pathway to induction of tolerance in the gut. Oral, epicutaneous, and sublingual routes of food immunotherapy are promising and induce desensitization in the majority of the treated subjects with food allergy but are not proven to restore permanent oral tolerance. Rigorous multicenter randomized clinical trials are necessary to elucidate the optimal timing, dose, duration, as well as the preventive and therapeutic effects of these diverse approaches.

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“…34 A recent study also showed that avoidance of cow milk by use of an extensively hydrolysed whey formula instead did not have a protective effect in infants in developing atopy (primarily eczema) at 12 months of age. 35,36 …”

Section: Cow Milk Allergymentioning

confidence: 99%

Weaning and complementary feeding in preterm infants: management, timing and health outcome

Barachetti¹,

Villa²,

Barbarini³

2017

Pediatr Med Chir

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The introduction of solid food is necessary for any infant in order to provide adequate nutrition because when they grow up milk is insufficient for their nutritional needs. Infants born preterm have increased nutritional requirements. The high nutrient demands as well as the organ immaturity of preterm infants combine to render it difficult to achieve dietary intakes that will allow preterm infants to match their in utero growth rates. Current guidelines for the introduction of solid food to term infants cannot be directly translated to preterm infants. For preterm infants such guidelines are lacking. Based on the limited available evidence, it could be concluded that a corrected age of 3 months (13 weeks) may be an appropriate age to start introducing solid food for most preterm infants. About celiac disease (CD), gluten may be introduced into the infant’s diet anytime between 4 and 12 completed months of age. In children at high risk for CD, earlier introduction of gluten (4 vs 6 months or 6 vs 12 months) is associated with earlier development of CD autoimmunity (defined as positive serology) and CD, but the cumulative incidence of each in later childhood is similar. Relatively to weaning and allergies, the European Society of Pediatric Allergy and Clinical Immunology and the European Society for Paediatric Gastroenterology Hepatology and Nutrition have produced joint guidelines. They recommend exclusive breastfeeding for 4–6 months or use of hypoallergenic formulas if exclusive breastfeeding is not possible. In addition, The American Academy of Pediatrics recommendations now state that there is no evidence to recommend maternal dietary restrictions during pregnancy or breastfeeding. However, there is no evidence that delaying introduction of solids including allergenic foods after 4–6 months is protective.

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Prebiotic‐supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high‐risk infants: a randomized controlled trial

Cited by 92 publications

References 25 publications

Identification of peptides with tolerogenic potential in a hydrolysed whey‐based infant formula

Identification of peptides with tolerogenic potential in a hydrolysed whey‐based infant formula

Mechanisms of Tolerance Induction

Weaning and complementary feeding in preterm infants: management, timing and health outcome

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