Relationship between <i>miR-143/145</i> cluster variations and cancer risk: proof from a Meta-analysis

Harati‐Sadegh, Mahdiyeh; Sargazi, Saman; Saravani, Mohsen; Sheervalilou, Roghayeh; Mirinejad, Shekoufeh

doi:10.1080/15257770.2021.1916030

Cited by 17 publications

(6 citation statements)

References 32 publications

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“…The C allele of rs4705342 has been reported as a risk factor for developing intracranial aneurysm and prostate cancer (14,22). However, a protective role was observed for the rs4705342 C variant against cancer risk in a meta-analysis (23).…”

Section: Discussionmentioning

confidence: 90%

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Kong

Duan²,

Wang³

et al. 2022

Front. Endocrinol.

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ObjectiveTo explore the association between two polymorphisms of microRNA-143 (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese Han population.Study DesignThis case–control study involved 326 patients with T2DM and 342 healthy controls. Two genetic variants (rs4705342 and rs353292) of miR-143 were genotyped by the polymerase chain reaction/ligase detection reaction (PCR-LDR) method. The levels of miR-143 in the serum from 52 T2DM patients and 55 healthy subjects were investigated by quantitative real-time PCR (qRT–PCR).ResultsThe CC genotype frequency of rs4705342 was significantly higher in the T2DM patients than in the healthy controls (P = 0.012). After adjusting for sex, age, and body mass index, the rs4705342 CC genotype was also related to a significantly increased risk of T2DM compared with the TT genotype (adjusted OR: 1.87; 95% CI = 1.09-3.19; P = 0.022). Stratified analyses demonstrated that T2DM patients with the rs4705342 CC genotype had significantly higher levels of low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), and glycated haemoglobin (HbA1C) than those carrying the rs4705342 TT genotype. The qRT–PCR results showed that the expression levels of miR-143 were significantly higher in the serum of cases than in the serum of controls (P < 0.001). Furthermore, the levels of miR-143 were significantly higher in the serum of T2DM patients carrying the rs4705342 CC genotype than in those carrying the TC and TT genotypes of rs4705342 (P = 0.005 and 0.003, respectively).ConclusionThe CC genotype of rs4705342 might be a risk factor for developing T2DM by increasing the expression of miRNA-143 in the northern Chinese Han population.

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Section: Discussionmentioning

confidence: 90%

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Kong

Duan²,

Wang³

et al. 2022

Front. Endocrinol.

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“…miR-143 and miR-145 were significantly upregulated in patients with endometriosis and ECO as compared to controls. Both miR-143 and miR-145 are the part of miR-143/145 cluster which is co-expressed usually in many types of cancers 27 . In endometriosis, both miR-143 and miR-145 were found upregulated in previous studies 15 , 28 and play an important role in pathophysiology by targeting genes such as mitogen-activated protein kinase 7, Kirsten rat sarcoma viral oncogene homologue, junctional adhesion molecule A and plasminogen activator inhibitor 1 29 .…”

Section: Discussionmentioning

confidence: 99%

Role of serum microRNAs as biomarkers for endometriosis, endometrioid carcinoma of ovary & endometrioid endometrial cancer

et al. 2022

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“…In addition, previous reports have shown various expression of caspase genes among the NHL subtypes (Lan et al, 2009;Sargazi et al, 2020). Previous studies have shown that genetic variants may alter expression or function of apoptotic proteins within the tumor (Xie et al, 2016;Harati-Sadegh et al, 2021b). Moreover, the evidence proposed that genetic variation is involved in etiology of NHL (Rendleman et al, 2014).…”

Section: Research Articlementioning

confidence: 99%

The Effect of Caspase 8, 9 Gene Polymorphisms on Non-Hodgkin Lymphoma Susceptibility and Clinical/Pathological Features

Barati

Bahari

Asadi

et al. 2022

Asian Pac J Cancer Prev

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Background: Caspases (CASPs) are the main executors of the apoptotic process. Studies to date have shown the role of caspase-8 (CASP8) and caspase-9 (CASP9) in carcinogenesis. Therefore, the aim of this study was to investigate the associations between CASP9-rs4233532, CASP9-rs4646018, and CASP8-rs1045485 gene polymorphisms and non-Hodgkin lymphoma (NHL) susceptibility in an Iranian population-based study. Moreover, it was examined whether such the genotype of these polymorphisms is related with clinicopathological characteristics of NHL. Methods: 175 patients with NHL and 175 age-and sex-matched controls were enrolled in this study. We determined the genotypes of single nucleotide polymorphisms (SNPs) from CASP genes with Tetra ARMS-PCR (Amplification refractory mutation system) method. Results: Statistically significant association were observed between CASP9-rs4646018 and increased risk of NHL under codominant CC, codominant TC, and dominant TC+CC genetic models. Our results showed that the A allele of CASP8-rs1045485 was a protective factor for NHL and GArs1045485 genotype significantly reduced risk of NHL. In contrast, CASP9-rs4233532 was not linked to NHL susceptibility. No relationship was detected between CASP8-rs1045485 and CASP9-rs4233532 and NHL clinicopathological characteristics, however genetic variation in CASP9-rs4646018 was associated with histology, treatment and radio therapy of NHL. Conclusions: Our study presented that the CASP8-rs1045485 and CASP9-rs4646018 polymorphisms could affect the risk of NHL in Iranian populations which was the first report to show the significant relationship between rs1045485, rs4646018 polymorphisms and NHL susceptibility. Replication large-scale case-control studies in different ethnicities are warranted to verify these findings.

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Relationship between miR-143/145 cluster variations and cancer risk: proof from a Meta-analysis

Cited by 17 publications

References 32 publications

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Role of serum microRNAs as biomarkers for endometriosis, endometrioid carcinoma of ovary & endometrioid endometrial cancer

The Effect of Caspase 8, 9 Gene Polymorphisms on Non-Hodgkin Lymphoma Susceptibility and Clinical/Pathological Features

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