Relationship betweenMCP-1promoter -2518 A/G gene polymorphism (rs1024611) and systemic lupus erythematosus/lupus nephritis

Abstract

Results from the published studies on the association between monocyte chemoattractant protein-1 (MCP-1) promoter -2518 A/G (rs1024611) gene polymorphism and systemic lupus erythematosus (SLE)/lupus nephritis (LN) are still conflicting. This meta-analysis was performed to evaluate the relationship between MCP-1 A/G gene polymorphism and SLE/LN and to explore whether MCP-1 A allele, AA genotype or GG genotype could become a predictive marker for SLE/LN risk. Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 January 2014, and eligible investigations were synthesized using meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Sixteen investigations were identified for the analysis of association between MCP-1 A/G gene polymorphism and SLE, consisting of 2425 patients with SLE and 2567 controls. In the overall populations, Asians, Caucasian population, the association between MCP-1 A/G gene polymorphism and SLE susceptibility was not found. Interestingly, a trend toward an association between A allele/AA genotype and LN risk was observed in overall populations, although there was no statistical difference. However, this meta-analysis indicated that AA genotype was associated with LN risk in Caucasians (OR = 0.71; 95% CI: 0.54-0.93; p = 0.01). In conclusion, our results indicate that AA homozygous might be a significant genetic molecular marker to predict the SLE patients developing into LN in Caucasians. However, more investigations are required to further clarify this association.

Monocyte chemoattractant protein-1 (MCP-1)-2518 A/G polymorphism and lupus nephritis risk

“…Previous meta-analysis suggested that the polymorphism of MCP-1 gene was not associated with the incidence of LN, but which was associated with the susceptibility of LN in Caucasian population. [ 18 ] The results from the present meta-analysis have a certain differences. The differences may be due to the publication of the latest case-control studies, but it is still more likely to be further confirmed based on larger population and more ethnicities studies.…”

“…LN is a result of SLE. A previous research [ 18 ] found AA genotype might be a biomarker for the patients with SLE developing into LN, and the AA genotype was associated with the onset of SLE in Caucasians. Furthermore, a trend toward an association between A allele and LN risk was observed in Caucasians.…”

Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis

“…Second, the number of studies included was not sufficiently large, especially in ethnicity subgroup analysis, which may not provide enough statistical power to explore the real association between IL-21 rs2221903 polymorphisms and SLE susceptibility. Third, SLE is polygenic and may also be modulated by several other genetic markers beyond IL-21, including IL-10 (Liu et al, 2013), MCP-1 (Zhou et al, 2014a), CTLA-4 (Zhu et al, 2014), the vitamin D receptor (Zhou et al, 2014b), and several other candidate genes. Thus, our meta-analysis emphasizes that elucidating the pathogenesis of SLE would demand further evaluation of the potential gene-gene interactions.…”

Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis

“…Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease [1], and it remains a predominant cause of morbidity and mortality in SLE [2,3]. Genetic and environmental factors contribute to the development of LN, and patients typically experience alternating periods of flare-up and remission.…”