Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis

Zhou, Tian-Biao; Jiang, Zongpei; Zhou, Jia-Fan; Su, Ning

doi:10.1016/j.humimm.2014.08.201

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Results were expressed with odds ratios (OR) for dichotomous data, and 95% Confidence Intervals (CI) were also calculated. P < 0.05 was required for the overall OR to be deemed statistically significant [8,9]. I 2 was used to test the heterogeneity between the included studies.…”

Section: Discussionmentioning

confidence: 99%

Is There An Association Between Angiotensin II Type 1 Receptor A1166C Gene Polymorphism and Renal Scarring Susceptibility?

Zhou¹,

Xie²,

Lin³

et al. 2017

J Nephrol Kidney Dis

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Relationship between Angiotensin II Type 1 Receptor (AT1R) A1166C gene polymorphism and renal scarring risk is still controversial. This meta-analysis was performed to evaluate the association of AT1R A1166C gene polymorphism and renal scarring risk susceptibility. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases of PubMed, Embase and Cochrane Library. Three literatures were identified and included for the analysis of the relationship between AT1R A1166C gene polymorphism and renal scarring risk. We found that AT1R A1166C gene polymorphism was not associated with renal scarring susceptibility using the comparison of patients with scarring vs patients without scarring (C: OR=1.33, 95%CI: 0.83-2.13, P=0.23; CC: OR=1.71, 95%CI: 0.22-13.56, P=0.61; AA: OR=0.69, 95%CI: 0.39-1.21, P=0.20). Furthermore, AT1R A1166C gene polymorphism was also not associated with renal scarring risk using the comparison of patients with scarring vs healthy control. In conclusion, AT1R A1166C gene polymorphism was not associated with renal scarring risk susceptibility. However, more studies should be performed in the future.

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Section: Discussionmentioning

confidence: 99%

Is There An Association Between Angiotensin II Type 1 Receptor A1166C Gene Polymorphism and Renal Scarring Susceptibility?

Zhou¹,

Xie²,

Lin³

et al. 2017

J Nephrol Kidney Dis

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“…An increased risk of developing LN disease in African patients was reported in one study included in the meta-analysis. Overall, Zhou and co-workers [126] found no difference in CCR5∆32 gene distribution among SLE patients and LN patients, suggesting that CCR5∆32 cannot predict whether SLE patients will develop LN.…”

Section: Immune System Diseasesmentioning

confidence: 96%

“…The role of CCR5 in kidney inflammation is established (i.e., CCR5 + T-cells involved in immune responses cause scarring or thickening of interstitial tissues known as fibrosis) [125]. A meta-analysis conducted by Zhou and co-workers [126] revealed no association of CCR5∆32 with LN susceptibility in Asians and Caucasians. This result is based on five studies included in the meta-analysis.…”

Section: Immune System Diseasesmentioning

confidence: 99%

Metabolomics as an Approach to Characterise the Contrasting Roles of CCR5 in the Presence and Absence of Disease

Rautenbach

Williams

2020

IJMS

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Chemokine receptors such as C-C chemokine receptor 5 (CCR5) are activated through interaction with their ligands and are well known for their role in chemotaxis and signal transduction. While serving these roles, cellular responses are effected, hence the immune function of these molecules is established. Given the role of CCR5 in immune function and that the immune and metabolic systems are interlinked, subsequent immune-directed changes should be measurable at a metabolic level. Numerous investigations have reported on metabolic changes associated with CCR5 status in the presence of disease, so as to understand whether specific CCR5 genotypes, frequency and/or levels offer protection to the host or not. However, these metabolic changes were recorded using older conventional techniques. Depending on certain factors such as the disease model, the geography of the samples and/or the ethnic group under study, the role of CCR5 in disease differs. In addition, little is known about CCR5’s role in the absence of an enhanced inflammatory state, such as when infection persists. Metabolomics is defined as the study of metabolites and informs on metabolic changes within living organisms as induced by various stimuli, such as the interaction of CCR5 with its ligand. Since metabolomics reflects the underlying biochemical activity and state of cells/tissues, this review proposes it as a tool to clarify the contrasting roles of CCR5.

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Chemokine genetic polymorphism in human health and disease

Qidwai

2016

Immunology Letters

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Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis

Cited by 4 publications

References 19 publications

Is There An Association Between Angiotensin II Type 1 Receptor A1166C Gene Polymorphism and Renal Scarring Susceptibility?

Is There An Association Between Angiotensin II Type 1 Receptor A1166C Gene Polymorphism and Renal Scarring Susceptibility?

Metabolomics as an Approach to Characterise the Contrasting Roles of CCR5 in the Presence and Absence of Disease

Chemokine genetic polymorphism in human health and disease

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