Relationship between hemorrheologic factors and insulin sensitivity in healthy young men

Moan, Andreas; Nordby, Gudmund; Os, Ingrid; Birkeland, Kåre I.; Kjeldsen, Sverre E.

doi:10.1016/0026-0495(94)90070-1

Cited by 80 publications

(67 citation statements)

References 36 publications

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“…9 The hemodynamic hypothesis of insulin resistance 10 suggests peripheral structural vascular changes and rarefaction to be determinants of insulin resistance. In support of this hypothesis, we have previously shown a positive correlation between insulin resistance and determinants of peripheral blood flow, such as calculated 4 and directly measured 3 WBV and structural vascular changes as assessed by MFVR. 8 Furthermore, in these young men, insulin resistance is closely and positively related to sympathetic activity and BP responses during mental stress, 8,11 and BP responses during mental stress correlate closely and positively with MFVR.…”

supporting

confidence: 54%

“…We performed a hyperinsulinemic, isoglycemic glucose clamp procedure, as previously described 4 and validated in detail. 15 The procedure clamps glucose level at the fasting level (isoglycemic) and not at a predetermined (euglycemic) level, ie, 5.0 mmol/L.…”

Section: Hyperinsulinemic Isoglycemic Glucose Clampmentioning

confidence: 99%

“…2 In our earlier studies of young men, recruited from the highest blood pressure (BP) percentiles during the compulsory military draft session in Oslo, we showed a positive correlation between insulin resistance and cardiovascular risk factors such as lipids 3 and body weight. 4 Physical fitness is a determinant of insulin sensitivity, 5-7 which we previously have not included in our studies of these apparently healthy 18-year-old men. In the present study, we therefore aimed to relate physical fitness to glucose disposal rate (GDR) in this well-described population of young men and to assess a possible mechanism for a relationship; ie, whether there is a direct relationship or whether it is influenced or determined by other correlates of GDR, such as lipids, body weight, minimal forearm vascular resistance (MFVR), 8 or whole blood viscosity (WBV).…”

mentioning

confidence: 99%

“…In the present study, we therefore aimed to relate physical fitness to glucose disposal rate (GDR) in this well-described population of young men and to assess a possible mechanism for a relationship; ie, whether there is a direct relationship or whether it is influenced or determined by other correlates of GDR, such as lipids, body weight, minimal forearm vascular resistance (MFVR), 8 or whole blood viscosity (WBV). 3,4 We assessed physical fitness as the total work performed during an ergometer bicycle exercise test divided by body weight because this technique for assessing physical fitness rather strongly predicts cardiovascular mortality in healthy, middle-aged Norwegian men. 9 The hemodynamic hypothesis of insulin resistance 10 suggests peripheral structural vascular changes and rarefaction to be determinants of insulin resistance.…”

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confidence: 99%

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Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

et al. 1999

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Abstract-Insulin resistance is related to physical inactivity, which is a risk factor for cardiovascular disease and death.Moreover, blood pressure responses during the first 6 minutes of an exercise test (600 kilo/pound/meter [kpm] per min) are more predictive for cardiovascular morbidity and mortality than blood pressure at rest, which could reflect that exercise blood pressure correlates more closely to peripheral structural vascular changes than casual blood pressure. We have recently shown a correlation between insulin resistance and minimal forearm vascular resistance (MFVR) in young men recruited from the highest blood pressure percentiles during a military draft session. In the present study, we tested the hypotheses that insulin sensitivity relates to physical fitness and that blood pressure responses during an exercise test relate to peripheral structural vascular changes in these men; we also tested whether these findings were interrelated. We assessed insulin sensitivity and physical fitness in 27 young men randomly selected from the cohort having a blood pressure of 140/90 mm Hg or higher during the compulsory military draft session in Oslo. Insulin sensitivity correlated with physical fitness (rϭ0.58, Pϭ0.002). Systolic blood pressure after 6 minutes of exercise (600 kpm/min) correlated with MFVR (rϭ0.46, Pϭ0.015). MFVR and physical fitness independently explained 60% of the variation in insulin sensitivity, and MFVR independently explained 19% of the variation of systolic blood pressure after 6 minutes of exercise. In conclusion, insulin sensitivity is related to physical fitness and exercise blood pressure to structural vascular properties in these young men. (Hypertension. 1999;33:781-786.)Key Words: insulin resistance Ⅲ exercise Ⅲ blood pressure Ⅲ physical fitness Ⅲ vascular structure I nsulin resistance 1 has been proposed as the metabolic link between non-insulin-dependent diabetes mellitus, hypertension, and atherosclerotic cardiovascular disease. 2 In our earlier studies of young men, recruited from the highest blood pressure (BP) percentiles during the compulsory military draft session in Oslo, we showed a positive correlation between insulin resistance and cardiovascular risk factors such as lipids 3 and body weight. 4 Physical fitness is a determinant of insulin sensitivity, 5-7 which we previously have not included in our studies of these apparently healthy 18-year-old men. In the present study, we therefore aimed to relate physical fitness to glucose disposal rate (GDR) in this well-described population of young men and to assess a possible mechanism for a relationship; ie, whether there is a direct relationship or whether it is influenced or determined by other correlates of GDR, such as lipids, body weight, minimal forearm vascular resistance (MFVR), 8 or whole blood viscosity (WBV). 3,4 We assessed physical fitness as the total work performed during an ergometer bicycle exercise test divided by body weight because this technique for assessing physical fitness rather strongly predic...

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confidence: 54%

Section: Hyperinsulinemic Isoglycemic Glucose Clampmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

et al. 1999

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“…This technique for measuring insulin sensitivity has a coefficient of variation of 5% in our laboratory, as previously detailed. 9,10 Blood pressure measurement and analytical methods Blood pressure was measured with a mercury sphygmomanometer with adequate cuff size and after 5 min rest in sitting position. The pressure was measured at least three times and the values registered were the mean of the two latest measurements.…”

Section: Hyperinsulinaemic Isoglycaemic Glucose Clamp Techniquementioning

confidence: 99%

Improved insulin sensitivity with the angiotensin II-receptor blocker losartan in patients with hypertension and other cardiovascular risk factors

et al. 2006

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We aimed to compare the effects of two different vasodilating principles, angiotensin II-receptor blockade and calcium channel blockade, on peripheral insulinmediated glucose uptake in patients with hypertension and other cardiovascular risk factors. Twenty-one hypertensive patients (11 women and 10 men) with mean age 58.6 years (range 46-75 years), body mass index 29.271.0 kg/m 2 and blood pressure 16073/ 9672 mm Hg entered a 4-week run-in period with open-label amlodipine 5 mg. Thereafter they were randomized double-blindly to additional treatment with amlodipine 5 mg or losartan 100 mg. After 8 weeks of treatment, all patients underwent clinical examination and laboratory testing, and 17 of them underwent a hyperinsulinaemic isoglycaemic glucose clamp. After a 4-week open-label wash-out phase, the participants crossed over to the opposite treatment regimen and final examinations with hyperinsulinaemic isoglycaemic glucose clamp after another 8 weeks. Blood pressure was lowered to the same level in both treatment periods. The glucose disposal rate was significantly higher after treatment with losartan 100 mg þ amlodipine 5 mg compared to amlodipine 10 mg (4.970.4 vs 4.270.5 mg/kg/ min, P ¼ 0.039). Thus our data suggest that angiotensin II-receptor blockade with losartan improves glucose metabolism at the cellular level beyond what can be expected by the vasodilatation and blood pressure reduction alone.

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Hemoglobin concentration and incident metabolic syndrome: a population-based large-scale cohort study

et al. 2015

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Previous cross-sectional studies revealed an association between hemoglobin concentration and a prevalence of metabolic syndrome (MetS). However, the association between hemoglobin concentration and incident MetS remains to be elucidated. Thus, the aim of this study was to investigate the association between hemoglobin concentration and incident MetS. We enrolled 2695 subjects (1454 men and 1241 women) and performed 8-year follow-up cohort study. MetS was diagnosed, according to the joint interim statement, when a subject had three or more of the following components: hypertension; hyperglycemia; hypertriglyceridemia; low high-density lipoprotein cholesterol; and abdominal obesity. Logistic regression analyses were performed to assess the impact of hemoglobin concentration on incident MetS by adjusting for age, body mass index, lifestyle factors, including smoking status, habit of alcohol and habit of exercise, systolic blood pressure, fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, creatinine, and uric acid. The highest (≥157 g/L) and third (151-156 g/L) hemoglobin concentration quartiles were associated with the increased risk of incident MetS compared to the lowest (<145 g/L) hemoglobin concentration quartile after adjusting for covariates in men (multivariate odds ratio (OR) 2.24, 95% CI 1.34-3.85, P = 0.0021 and multivariate OR 2.03, 95% CI 1.21-3.45, P = 0.0070). On the other hand, there was no association between hemoglobin concentration and incident MetS in women. Hemoglobin concentration was a novel risk marker for incident MetS in men.

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Relationship between hemorrheologic factors and insulin sensitivity in healthy young men

Cited by 80 publications

References 36 publications

Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

Insulin Sensitivity Is Related to Physical Fitness and Exercise Blood Pressure to Structural Vascular Properties in Young Men

Improved insulin sensitivity with the angiotensin II-receptor blocker losartan in patients with hypertension and other cardiovascular risk factors

Hemoglobin concentration and incident metabolic syndrome: a population-based large-scale cohort study

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