Relationship Between Heart Rate Turbulence and Heart Rate, Heart Rate Variability, and Number of Ventricular Premature Beats in Coronary Patients

Cygankiewicz, Iwona; Wranicz, Jerzy Krzysztof; Bolińska, H; Zasłonka, Janusz; Zaręba, Wojciech

doi:10.1046/j.1540-8167.2004.03613.x

Cited by 36 publications

(30 citation statements)

References 20 publications

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“…The results were consistent with previous studies in patients with coronary artery disease [11]. The real physiological meaning of HRT is unknown.…”

Section: Discussionsupporting

confidence: 92%

Relationship of heart rate turbulence, heart rate variability and the number of ventricular premature beats in patients with mitral valve prolapse and non-significant regurgitation

Chen

2009

International Journal of Cardiology

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“…The results were consistent with previous studies in patients with coronary artery disease [11]. The real physiological meaning of HRT is unknown.…”

Section: Discussionsupporting

confidence: 92%

Relationship of heart rate turbulence, heart rate variability and the number of ventricular premature beats in patients with mitral valve prolapse and non-significant regurgitation

Chen

2009

International Journal of Cardiology

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“…Some clinical studies show only single correlations between HRT and HRV parameters; however, there are several others in the literature that indicate high correlations. Those studies were performed on adult populations in which the myocardial infarction or the coronary incidents were noted (11,14,15). In our study, we found the correlations between HRT and HRV parameters predominantly occur in the youngest group of children, in which modulation of autonomic nervous systemand, hence, its influence on heart function-seems to be rather small.…”

supporting

confidence: 46%

“…These values are similar to the ones presented in our study. Since TO reflects fast changes in successive sinus RR intervals, it seems to be less dependent on the heart rate (11,18). In our research, there were no differences in the values of TO between the groups, which varied in the heart rate preceding VPB.…”

mentioning

confidence: 41%

“…The RR intervals with following characteristic Ͻ200 ms and Ͼ2000 ms, with jumps Ͼ200 ms from one interval to the next, were excluded from the heart rate turbulence analysis (10). Additionally, VPBs with too long coupling intervals or too short compensatory pause were rejected (the HRT calculation was limited to VPBs with a minimum prematurity of 20% and a postextrasystole interval which was at least 20% longer than the reference interval (mean of the five last sinus intervals preceding VPB) (11).…”

Section: Methodsmentioning

confidence: 99%

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Heart Rate Turbulence in Children—Age and Heart Rate Relationships

Kowalewski¹,

Adam

Bochen

et al. 2007

Pediatr Res

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Heart rate turbulence (HRT) is a chronotropic response of the sinus heart rhythm to ventricular premature beat (VPB). Children show decreasing heart rate together with the maturation of the autonomic nervous system. The aim of the research was to assess the relationship between HRT parameters, age, and heart rate and time domain heart rate variability (HRV) parameters in healthy children. Twenty-four-hour ECG Holter recording was performed on 398 healthy children. The mean RR interval preceding VPB, number of VPBs, and HRT parameters-turbulence onset (TO) and turbulence slope (TS)-were determined. We observed significant correlation among TS and mean RR and age. Children with prepubertal status have lower values of TS compared with those during puberty. According to given quartiles, upper for TO was Ն-0.8%, lower for TS was Յ4.56 ms/RR, 13 patients (3%) obtained abnormal both TO and TS. The correlations between HRT and HRV parameters were observed among the youngest children. Age and heart rate preceding VPB have no effect on HRT onset in children, whereas HRT slope is highly dependent on these variables. Our results support hypothesis that in older children HRT is dependent on autonomic tone and also determined by other intrinsic modulators. T he term "heart rate turbulence" (HRT) was first used by Schmidt et al. (1) and refers to changes in the sinus heart rhythm after ventricular premature beat (VPB). The response consists of a short phase of early heart rate acceleration followed by heart rate deceleration. HRT can be quantified by two parameters, turbulence onset (TO) and turbulence slope (TS), which are strong and independent markers of a sudden cardiac death risk in various patients' cohorts (1,2). The underlying mechanism of described parameters is connected with compensatory activation of baroreceptor reflex triggered by a decreased stroke volume following a VPB. The HRT response is believed to be under strong dependence on parasympathetic activity and heart rate preceding VPB (3). Recent studies have shown that HRT phenomenon can be used as an alternative measure of baroreflex sensitivity (4,5).A few studies demonstrate that in healthy subjects increasing age is associated with a decrease of HRT slope (6,7), likewise an increase in heart rate is relevant to TO decrease. However, there is a lack of information about heart rate turbulence behavior after VPB and the potential influence of age and pubertal status on healthy subjects within first two decades of life. Changes in basic heart rhythm during child's development are influenced by breathing frequency, sleeping periods and maturation of sympathetic and parasympathetic systems (8). We hypothesized that in such population age heart rhythm may significantly influence the heart rate turbulence parameters.The aim of this study was to determine the correlation among the HRT parameters, age, heart rate, heart rate variability (HRV) parameters and pubertal status in healthy children. MATERIALSAll the participants had a documented history of vent...

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“…TS has been shown to depend on heart rate both across (12,13) and within individuals (14). as suggested by Hallstrom et al (7) for each hour in CAST.…”

Section: Heart Rate and Hrtmentioning

confidence: 83%

Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functions

Watanabe

Alford

Schneider³

et al. 2007

Heart Rhythm

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Relationship Between Heart Rate Turbulence and Heart Rate, Heart Rate Variability, and Number of Ventricular Premature Beats in Coronary Patients

Abstract: HRT parameters correlate strongly with HRV parameters indicating that HRT should be considered as a reflection of both baroreceptors response and overall autonomic tone. Heart rate dependence of turbulence slope indicates the need to adjust this parameter for heart rate.

Cited by 36 publications

References 20 publications

Relationship of heart rate turbulence, heart rate variability and the number of ventricular premature beats in patients with mitral valve prolapse and non-significant regurgitation

Relationship of heart rate turbulence, heart rate variability and the number of ventricular premature beats in patients with mitral valve prolapse and non-significant regurgitation

Heart Rate Turbulence in Children—Age and Heart Rate Relationships

Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functions

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