Relationship between glycated hemoglobin and glucose concentrations in the adult Galician population: selection of optimal glycated hemoglobin cut-off points as a diagnostic tool of diabetes mellitus

López, Manuel Antonio Botana; López-Ratón, Mónica; Tomé, María Ausencia; Mariño, Alexis Fernández; Mato, José Antonio Mato; Iraeta, Antonia Rego; Fernández, Román Pérez; Suárez, Carmen María Cadarso

doi:10.1016/j.endonu.2012.06.001

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…This was also the case in the current screening in which 42% of participants had pre-diabetic HbA1c values compared to 35% or 12% having pre diabetic IFG levels according to ADA or WHO criteria, respectively. These results were confirmed in other studies reporting higher rates of elevated FPG using HbA1c than FPG [37] or 2-hour OGTT [56]. However, some other studies showed comparable rates [43], and some missed cases or found lower rates when ADA's recommended cut-offs for HbA1c were applied [57,58].…”

Section: Limitationssupporting

confidence: 79%

Targeted Screening Reveals High Numbers of Prediabetes and Diabetes Mellitus in Moshi, Tanzania

Ludwig¹,

Streicher²

2017

J Diabetes Metab

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Objective: Chronic non-communicable diseases, such as type 2 diabetes mellitus, have become global major health problems. In the United Republic of Tanzania, previous studies showed diabetes prevalences ranging from 0.6% to 5.8% and of pre-diabetes, from 9.1% to 10.6%. The pre-diabetes screening procedure described here was a targeted screening to recruit eligible subjects for a subsequent dietary intervention in Moshi, Tanzania. Methods:The pre-diabetes screening procedure described here was used to identify subjects for a dietary intervention in Moshi, Tanzania. Main enrollment criteria for participants were fasting plasma glucose levels of 5.6-6.9 mmol/L (100-125 mg/dL) on two days or on one day plus HbA1c in the range of 5.7-7.5% (39-58% mmol/mol), body mass index of 27-35 kg/m², and age between 30-65 years.Results: Through pre-screening of a total of 1,256 people were examined for BMI and age; 382 people were further screened for markers of pre-diabetes. Following ADA and WHO-criteria, 51% (73%) had normal, 35% (13%) pre-diabetic, and 15% (15%) diabetic fasting plasma glucose levels. Among the individuals with hyperglycemia indicating diabetes mellitus, 60% were unaware of their condition. Applying ADA criteria for HbA1c to all people, 42% had normal, 42% had pre-diabetic, and 16% had diabetic HbA1c levels. Identified risk factors for increased fasting plasma glucose were age, waist circumference, body mass index, and a family history of diabetes mellitus. Conclusion:Although the screening sample was not representative for the study area's population and not diagnostic, the high rates of pre-diabetic and diabetic fasting plasma glucose levels are of public health concern. The low concordance between the data for FPG and HbA1c requires further investigation, as well as the discrepancy between ADA and WHO definitions of impaired fasting glucose.

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Section: Limitationssupporting

confidence: 79%

Targeted Screening Reveals High Numbers of Prediabetes and Diabetes Mellitus in Moshi, Tanzania

Ludwig¹,

Streicher²

2017

J Diabetes Metab

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“…Respecto a la asociación positiva entre HBA1C y glicemia (R 2 =0.61; 𝛽 1 =0.22), otros estudios también han demostrado una asociación positiva entre ambas variables con un valores de R 2 similares (Botana López et al, 2012;L. Feng et al, 2018;Khan et al, 2007).…”

Section: Discussionunclassified

Hemoglobina glicosilada en población diabética en periodo de pandemia covid-19 en un centro de atención primaria

et al. 2023

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Introducción. La diabetes mellitus tipo 2 (DM2) es una enfermedad metabólica que afecta todas las aristas de la vida individual y familiar de la persona que la padece. La pandemia causada por el virus de SARS-COV-2 ha generado un problema relevante a nivel del sistema de salud, provocando una sobrecarga importante y una complejizarían de los servicios para atender la infección. Lo anterior, ha llevado a que muchas personas pierdan sus controles crónicos y no puedan cuidarse de manera adecuada. Métodos. La prueba de Wilcoxon se utilizó para comparar grupos de pacientes y variables continuas. Se aplicó un modelo de regresión lineal para estudiar la asociación entre la glicemia y la hemoglobina glicosilada. Se consideró un valor p <0.05 para aceptar la hipótesis alternativa de las pruebas estadísticas. Resultados. Se encontraron diferencias significativas entre población con niveles inferiores a 9% de hemoglobina glicosilada y niveles superiores o iguales a 9% en variables como glicemia, colesterol total, colesterol HDL, colesterol LDL y triglicéridos. En el modelo de regresión lineal se reportó R2 (0.61) y (0.22) entre la glicemia y la hemoglobina glicosilada con significancia estadística en todos los niveles (valor p<0.05). Conclusiones. Un mal ajuste de los niveles de HBA1C en población con DM2 podría generar una serie de comorbilidades como dislipidemias, hipertensión, enfermedad cardiovascular o infarto agudo al miocardio producto de la glucotoxicidad y lipotoxicidad.

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Sex and age affect agreement between fasting plasma glucose and glycosylated hemoglobin for diagnosis of dysglycemia

Lorenzo-Medina

Uranga

Rus

et al. 2017

Endocrinología, Diabetes y Nutrición (English ed.)

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Relationship between glycated hemoglobin and glucose concentrations in the adult Galician population: selection of optimal glycated hemoglobin cut-off points as a diagnostic tool of diabetes mellitus

Cited by 5 publications

References 27 publications

Targeted Screening Reveals High Numbers of Prediabetes and Diabetes Mellitus in Moshi, Tanzania

Targeted Screening Reveals High Numbers of Prediabetes and Diabetes Mellitus in Moshi, Tanzania

Hemoglobina glicosilada en población diabética en periodo de pandemia covid-19 en un centro de atención primaria

Sex and age affect agreement between fasting plasma glucose and glycosylated hemoglobin for diagnosis of dysglycemia

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