Relationship Between Glutathione S-Transferase M1 Deficiency and Urothelial Cancer in Dye Workers Exposed to Aromatic Amines

Sendo, Toshiaki; Ogura, Hideaki; Morita, Teruo; Nishikawa, Toru; Fujinaga, Takuji; Ohkawa, Tadashi

doi:10.1016/s0022-5347(01)63924-7

Cited by 17 publications

(6 citation statements)

References 6 publications

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“…At present, the molecular mechanisms of the initiation and progression of bladder cancer are unclear, although many genetic factors have been found to be associated with it 3, 10, 11. Based on this, we speculate that survivin and livin genes probably play an important role in cell proliferation and tumor progression in NIMBC.…”

Section: Discussionmentioning

confidence: 75%

Expression of survivin and livin predicts early recurrence in non‐muscle invasive bladder cancer

Ren¹,

Sheng²,

Chen³

et al. 2012

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 75%

Expression of survivin and livin predicts early recurrence in non‐muscle invasive bladder cancer

Ren¹,

Sheng²,

Chen³

et al. 2012

Journal of Surgical Oncology

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“…Four studies have been conducted for GSTM1 polymorphisms in workers exposed to aromatic amines. Rothman et al (82), Ma et al (83) and Carreón et al (78) did not observe an association, while Shinka et al (84) reported a higher risk among those subjects carrying the GSTM1 null genotype, but the association did not reach statistical significance.…”

Section: Glutathione S-transferasesmentioning

confidence: 92%

The Genetic and Environmental Factors Involved in Benzidine Metabolism and Bladder Carcinogenesis in Exposed Workers

Carreón

LeMasters²,

Ruder³

et al. 2006

Front Biosci

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Genetic susceptibility to bladder cancer in individuals exposed to arylamines may be explained by interindividual metabolic differences that lead to arylamine bioactivation or detoxification. In this article, occupational bladder cancer risk factors and the evidence that links benzidine exposure to bladder cancer are reviewed. Benzidine metabolism is described and compared with that of other aromatic amines. Metabolic polymorphisms and bladder cancer in the context of occupational exposure to aromatic amines are also reviewed, and the environmental and genetic relationships of benzidine exposure and genetic susceptibility are outlined. Only a few studies of bladder cancer genetic susceptibility in populations exposed occupationally to arylamines have been published. The results of these case-control studies show conflicting results, reflecting metabolic differences between monoarylamines and diarylamines such as benzidine. Additional studies and pooled analyses of existing data are needed to establish if individuals are at higher risk of bladder cancer given the presence of certain alleles that make them more susceptible to this disease.

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“…The incidence of UC in Taiwan is higher than that of other parts of the world with an unusually high incidence of 50 per 100,000 person-years 2–4 . The development of UC can be associated with multiple factors such as smoking 5 , drinking groundwater that contains heavy metals 6 , exposures to environmental toxins such as dye 7 or organic solvent 8 , and Chinese herbs that contain aristolochic acid (AA). Aristolochic acid can be the cause of both CKD and UC 9–12 .…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for urothelial cancer in patients with chronic kidney disease

Shu

Chen

Wang

et al. 2019

Sci Rep

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Urothelial cancer (UC) is a common kidney cancer in Taiwan and patients with chronic kidney disease (CKD) are more at risk for UC than the general population. The diagnostic value of urine analysis and urine cytology is limited, especially in CKD patients. The aim of the study is to develop a nomogram to predict the risk of UC in CKD patients. We enrolled 169 UC patients and 1383 CKD patients from 9 hospitals in Taiwan between 2012 and 2015. CA125, HE4, clinical characteristics, and medical history were analyzed using multivariable logistic regression for its association with UC. A nomogram was developed to predict the risk of UC and was validated using Bootstrap. CA125 was associated with UC in CKD patients (OR: 5.91, 95% CI: 3.24–10.77) but HE4 was not (OR: 1.29, 95% CI: 0.67–2.35). A nomogram based on patients’ age, estimated glomerular filtration rate, CA125 (log transformed), smoking, exposure of environmental toxin, use of nonsteroid anti-inflammatory drugs, and use of traditional Chinese medicine was conducted. The AUC of the nomogram was 0.90 (95% CI: 0.86–0.92, p < 0.01). Serum CA125 may identify UC patients from CKD patients but has limited diagnostic value due to low sensitivity. The diagnostic value of serum CA125 level can be improved by the combination with clinical characteristics including age, renal function, and medical history.

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Relationship Between Glutathione S-Transferase M1 Deficiency and Urothelial Cancer in Dye Workers Exposed to Aromatic Amines

Cited by 17 publications

References 6 publications

Expression of survivin and livin predicts early recurrence in non‐muscle invasive bladder cancer

Expression of survivin and livin predicts early recurrence in non‐muscle invasive bladder cancer

The Genetic and Environmental Factors Involved in Benzidine Metabolism and Bladder Carcinogenesis in Exposed Workers

Development and validation of a nomogram for urothelial cancer in patients with chronic kidney disease

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