Expression of survivin and livin predicts early recurrence in non‐muscle invasive bladder cancer

Ren, Xi; Sheng, Yin; Chen, Wang Hong; Sheng, Li; Ji, Gang; Zhou, Tong; Zhang, Shan; Ying, Guo; Dong, Liu Chun

doi:10.1002/jso.23272

Cited by 24 publications

(20 citation statements)

References 27 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated to be expressed in transformed cells and multiple types of malignant tumor, including neuroblastoma (20) as well as carcinomas of the bladder (21,22), lung (23), nasopharynx (24), kidney (25), liver (26), colon/rectum (27), skin (28), bone (29) and stomach (30).…”

Section: Discussionmentioning

confidence: 99%

“…Livin, a novel member of the inhibitor of apoptosis (IAP) protein family, is not detected in the majority of normal tissues, however, is highly expressed in various types of human malignancy (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Increased activity of this protein may be used as a reliable prognostic factor for initial and late resistance to chemotherapeutic drugs in certain types of human tumor (31)(32)(33)(34)(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of livin expression suppresses cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma cells

Shen

et al. 2012

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. Livin is a novel member of the inhibitor of apoptosis protein family that has been reported to be overexpressed in various types of human malignancy. Although several studies have demonstrated that livin may be used as an effective target for tumor therapy, few studies have investigated its role in human lung adenocarcinoma. In the present study, two different methods were used in order to investigate the tumor-suppressing effect of livin in human lung adenocarcinoma cells. Firstly, small interfering (si)RNA technology was used to down regulate livin expression; siRNA-mediated knockdown of livin was confirmed using reverse transcription quantitative polymerase chain reaction and western blot analysis, and cell proliferations was assessed using an MTT assay in vitro. Secondly, inhibition of livin expression was induced through the synergistic inhibitory effect between flavopiridol and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Experimental results revealed that, following transfection of the livin gene-silencing vector, the gene expression of livin was markedly decreased, SPC-A1 cell proliferation was significantly reduced and the therapeutic effect of the chemotherapy drug cisplatin was markedly improved. This growth inhibitory effect was also observed in the flavopiridol and TRAIL combination treatment group. In the flavopiridol and TRAIL combination treatment group, the protein expression of livin was significantly reduced and the survival rate of SPC-A1 cells was significantly lower than the flavopiridol and TRAIL single operation group. In conclusion, the RNA silencing and the synergistic inhibitory effect between flavopiridol with TRAIL was able to effectively inhibit the expression of livin, significantly decrease SPC-A1 tumor cell proliferation and significantly enhance sensitivity to the chemotherapy drug cisplatin. These findings suggest that livin may be used as a novel target for tumor gene therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of livin expression suppresses cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma cells

Shen

et al. 2012

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…High nuclear livin protein expression is found to predict satisfactory prognosis of renal cell carcinoma [19], and children with acute lymphoblastic leukemia positive for livin protein are reported to have a satisfactory prognosis [20]. However, it appears that high expression of the livin gene predicts poor prognosis of breast cancer [21], and high livin protein expression is reported to be associated with early-stage relapse of breast cancer and the lymph node metastasis of ampullary carcinoma [22, 23]. In addition, livin expression is found not to be associated with the prognosis of HCC [24], and the expression of the livin gene is reported not to be related to the survival period of patients with non-small-cell lung cancer [6].…”

Section: Discussionmentioning

confidence: 99%

Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma

et al. 2013

View full text Add to dashboard Cite

In this study, the two-step PV method of immunohistochemistry was used to determine livin protein expression in HCC tissues, pericarcinoma tissues, hepatitis/hepatic cirrhosis tissues, and normal hepatic tissues, and livin protein expression was detected in the blood plasma of patients with HCC before and after surgery, subjects with hepatic cirrhosis and hepatitis, and healthy blood donors using ELISA. Livin protein expression was significantly higher in HCC tissues than that in normal hepatic tissues and hepatitis/hepatic cirrhosis tissues, with no significant difference between HCC tissues and pericarcinoma tissues. The HCC patients with positive livin protein expression had a significantly higher survival rate than those with negative livin protein expression. Livin protein expression was significantly higher in the blood plasma of patients with HCC before and after surgery and in patients with hepatic cirrhosis and hepatitis than that in healthy blood donors, whereas livin protein expression in the blood plasma of patients with HCC was not significantly different from that of patients with hepatic cirrhosis and hepatitis. Livin protein expression in HCC tissues did not correlate with that in the blood plasma of the same HCC patients. Livin protein expression may be a potential, effective indicator for assessing prognosis in patients with HCC.

show abstract

“…We previously demonstrated that survivin/BIRC5 has a higher expression in adrenocortical tumors than in normal adrenal glands and that its expression correlates with prognosis in ACC group [36]. Several studies indicated that livin and survivin play together an important role in the tumorigenesis and in the clinical outcome of several human cancers [18, 37]. The expression of other components of IAP family has been poorly evaluated in adrenocortical tissues [22].…”

Section: Introductionmentioning

confidence: 99%

Livin/BIRC7 expression as malignancy marker in adrenocortical tumors

et al. 2016

View full text Add to dashboard Cite

Relative livin mRNA expression was significantly higher in ACC than in ACA and NAG (0.060 ± 0.116 vs 0.004 ± 0.014 and 0.002 ± 0.009, respectively, p < 0.01), being consistently higher in tumors than in adjacent NAG and isoform β more expressed than α. No significant differences in CASP3, XIAP and DIABLO levels were found among these groups. In immunohistochemistry, livin was localized in both cytoplasm and nuclei.The ratio between cytoplasmic and nuclear staining was significantly higher in ACC (1.51 ± 0.66) than in ACA (0.80 ± 0.35) and NAG (0.88 ± 0.27; p < 0.0001). No significant correlations were observed between livin expression and histopathological parameters or clinical outcome. In NCI-H295R cells, the livin overexpression slightly reduced the activation of CASP3, but did not correlate with cell viability.In conclusion, livin is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecular marker of malignancy.

show abstract

Expression of survivin and livin predicts early recurrence in non‐muscle invasive bladder cancer

Abstract: Expression of survivin and livin may influence the prognosis of NIMBC. This finding opens new perspectives for Survivin and livin prediction of early recurrence in NIMBC.

Cited by 24 publications

References 27 publications

Inhibition of livin expression suppresses cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma cells

Inhibition of livin expression suppresses cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma cells

Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma

Livin/BIRC7 expression as malignancy marker in adrenocortical tumors

Contact Info

Product

Resources

About