Relationship between glucagon-like peptide-1 receptor gene polymorphism and bone mineral density in postmenopausal women in Shanghai

Abstract

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are able to inhibit bone resorption to a certain extent and improve bone formation. GLP-1R single nucleotide polymorphism (SNP) is related to its activity, but the relationship between GLP-1R SNP and osteoporosis in postmenopausal women was still unclear. This study was to investigate the association between GLP-1R SNP and bone mineral density (BMD) in postmenopausal women in Shanghai.Methods: Eight SNPs of GLP-1R were detected (rs3765467, rs1042044, rs2268657, rs6923761, rs2268641, rs2295006, rs4714210 and rs10305420) in 884 postmenopausal women in Shanghai. The correlation between GLP-1R SNP and BMD was further assessed. Results:The A/A genotype of rs2295006 was negatively related to lumbar vertebrae 1-4 BMD (P<0.05).Allele A was negatively related to hip BMD (P<0.05). There was a negative correlation between haplotype CGAGCCA and lumbar BMD, and a positive correlation between haplotype CGGGCTA and lumbar BMD.The remaining seven GLP-1R SNPs had no relationship with BMD. Conclusions:The rs2295006 of GLP-1R is related to the BMD of postmenopausal women in Shanghai, China.

Polymorphisms in the glucagon-like peptide-1 receptor gene and their interactions on the risk of osteoporosis in postmenopausal Chinese women

“…Moreover, high levels of whole-body fat and lean tissue content positively correlated with peak BMDs at the LS, FN, and TH [ 12 ], suggesting that rs1042044 may indirectly influence BMD. A negative correlation was observed between the rs2295006 A/A genotype and haplotype and BMDs, as reported in another study [ 8 ]. However, further research is needed to establish conclusive evidence regarding the relationship between the GLP-1R SNPs and PMOP.…”

“…Since Morrison et al’s groundbreaking work in 1994, which identified the association of genetic polymorphisms in the vitamin D receptor with susceptibility to OP [ 6 ], a genome-wide association study has discovered multiple single nucleotide polymorphisms (SNPs) located at various genetic locus linked to the risk of OP [ 7 ]. Furthermore, evidence supports a genetic association between glucagon-like peptide-1 receptor (GLP-1R) gene polymorphisms and susceptibility to OP [ 8 ].…”

“…The GLP-1R gene is located on chromosome 6 (6p21.2), and its biological impact is mediated by glucagon-like peptide 1 [ 11 ]. A recent study suggested that a SNP in the GLP-1R gene (rs1042044) may indirectly influence BMD [ 12 ]; specifically, the A allele of GLP-1R rs2295006 and haplotype were found to be negatively correlated with BMD in the postmenopausal population [ 8 ]. However, the specific genetic polymorphisms responsible for susceptibility to PMOP remain largely unknown.…”

GIPR rs10423928 and bone mineral density in postmenopausal women in Shanghai

“…Both GLP-1 and GIP are incretins. Previously, we demonstrated a correlation between GLP-1 receptor gene ( GLP-1R ) polymorphisms and BMD in postmenopausal women in Shanghai, China ( 18 ). Therefore, we aimed at elucidating whether there is a correlation between GIP/GIPR and BMD and whether GIPR mutations affect the effects of GIP/GIPR.…”

Relationship Between GIP Receptor Gene Polymorphism rs10423928 and Bone Mineral Density in Postmenopausal Women in Shanghai

“…GIP is an intestinal insulinotropic hormone that is synthesized and secreted by K cells of the duodenum and jejunum, and exerts a biological effect by binding to the corresponding GIP receptor (GIPR) on the cell surface: promotes the secretion of insulin in the rst phase; improves the body's sensitivity to insulin. Our previous studies have demonstrated that there was the correlation between polymorphisms of GLP-1R gene and BMD of lumbar spine, femoral neck, and total hip in postmenopausal women of Han nationality in Shanghai, China (12). Howerver, it is unclear whether there is a correlation between polymorphisms of GIPR gene and osteoporosis.…”