Relationship between Frequency Dependence of Lung Compliance and Distribution of Ventilation

Wanner, Adam; Zarzecki, S.; Atkins, Neal; Zapata, Á. Lancharro; Sackner, Marvin A.

doi:10.1172/jci107863

Cited by 11 publications

(6 citation statements)

References 20 publications

(26 reference statements)

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“…Smokers with values of the Phase III slope greater than the upper bound of predicted normal range (i.e., mean + 2 standard errors) were classified as the small airways disease group (17). In some smokers dynamic lung compliance was also measured at a breathing frequency of 60 breaths/min to confirm the results of single-breath N2 washout tests (18). All smokers had a smoking history of a pack of cigarettes per day for at least 3 yr.…”

Section: Subjectsmentioning

confidence: 92%

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Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease.

Kim

Kang²

1997

Am J Respir Crit Care Med

152

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Particulate pollutants have been suggested as a risk factor for increase in mortality and morbidity in patients with obstructive airway disease. In the present study we hypothesized that enhanced particle deposition dose is an underlying factor for such a finding. We measured lung deposition in normal healthy control subjects (N; n = 10) and in subjects with varying levels of airway obstruction: smokers (S; n = 10), smokers with small airways disease (SAD; n = 10), asthmatics (A; n = 5), and patients with chronic obstructive airway disease (COPD; n = 10). The subjects inhaled a uniform size sebacate aerosol (1-micron diameter) from a collapsible bag of a known volume (500 ml) repeatedly for as many as 15 breaths at a rate of 30 breaths/min. Aerosol concentration was monitored continuously at the mouth by a laser aerosol photometer. After correcting for particle loss in the bag, lung deposition fraction [DF = (inhaled minus exhaled)/inhaled], was determined breath by breath. DF values (mean +/- SD) were 0.14 +/- 0.02, 0.16 +/- 0.02, 0.21 +/- 0.05, 0.22 +/- 0.02 and 0.028 +/- 0.03 for N, S, SAD, A, and COPD, respectively. DF values in S, SAD, A, and COPD were 16, 49, 59, and 103% greater, respectively, than that of normal subjects (p < 0.05). DF of COPD was also greater than that of SAD or A (p < 0.05). No difference was found between SAD and A. When all of the subject data were combined, DF was correlated well with percent predicted FEV1 and FEF25-75 (r2 = 0.63 in both). The results indicate a marked increase in particle deposition in patients with obstructive lung disease, and this can be an important factor for the development of the adverse health effects of pollutant particles on the one hand and for the treatment of patients with drug aerosols on the other.

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Section: Subjectsmentioning

confidence: 92%

“…12 14 16 18 20 22 24 26 28 30 32 sRaw, cm H 20.sec Deposition fraction values plotted as a function of specific airway resistance (SRaw) for all subjects. A linear regression line (solid fine) and 95% confidence intervals (dashed lines) are also shown.…”

mentioning

confidence: 99%

Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease.

Kim

Kang²

1997

Am J Respir Crit Care Med

152

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“…A limitation of this measurement is that the large airways can also contribute to an abnormal phase III slope. 17,18 In this context the multiple-breath nitrogen washout (MBNW) test is an important improvement because it is able to distinguish between ventilation heterogeneity generated in the conductive lung zone (Scond) and ventilation heterogeneity generated in the acinar lung zone (Sacin), with a cutoff around the 15th generation. 19 Farah et al 20 demonstrated that patients with poorly controlled asthma have higher Scond and Sacin values than patients with well-controlled asthma.…”

Section: Asthma Symptoms and Controlmentioning

confidence: 99%

Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: A systematic review

Wiel

Hacken

Postma

et al. 2013

Journal of Allergy and Clinical Immunology

159

100

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“…It presented a calculation of lung input impedance, and eventually led to a number of studies in human subjects of the frequency dependence of compliance. In being able to detect lung heterogeneity, this frequency dependence of compliance (and resistance) was thought to be an early marker for lung disease (51, 68, 83, 158, 176, 189). Despite these and several other studies showing the frequency dependence in human subjects with different lung pathologies, the procedure was not widely utilized, in part because the technique was not easy to do for routine screening.…”

Section: B Dynamic Mechanical Propertiesmentioning

confidence: 99%

Mechanics of the Lung in the 20th Century

Mitzner

2011

Comprehensive Physiology

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Major advances in respiratory mechanics occurred primarily in the latter half of the 20th century, and this is when much of our current understanding was secured. The earliest and ancient investigations involving respiratory physiology and mechanics were often done in conjunction with other scientific activities and often lacked the ability to make quantitative measurements. This situation changed rapidly in the 20th century, and this relatively recent history of lung mechanics has been greatly influenced by critical technological advances and applications, which have made quantitative experimental testing of ideas possible. From the spirometer of Hutchinson, to the pneumotachograph of Fleisch, to the measurement of esophageal pressure, to the use of the Wilhelmy balance by Clements, to the unassuming strain gauges for measuring pressure and rapid paper and electronic chart recorders, these enabling devices have generated numerous quantitative experimental studies with greatly increased physiologic understanding and validation of mechanistic theories of lung function in health and disease.

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Relationship between Frequency Dependence of Lung Compliance and Distribution of Ventilation

Cited by 11 publications

References 20 publications

Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease.

Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease.

Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: A systematic review

Mechanics of the Lung in the 20th Century

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