Relationship between follicular fluid and serum anti-Mullerian hormone levels and pregnancy rate in ART cycles

Zargar, Mahvash; Najafian, Mahin; Zamanpour, Z.

doi:10.1016/j.rprh.2018.03.001

Cited by 2 publications

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“…Traditional techniques used to predict ovarian stimulation have incorporated serum levels of hormones such as FSH, LH and estrogen (E 2 ) along with ultrasonographic guides such as ovarian volume and number of early antral follicles as a reliable predictor of the outcome of in vitro fertilization (IVF) ( Kunt et al, 2011 ). Over the last few years, the anti-Müllerian hormone (AMH) has been projected as a novel marker for predicting ovarian response to gonadotrophin stimulation ( Alson et al, 2018 ; Zargar, Najafian & Zamanpour, 2018 ). AMH is a dimeric glycoprotein strongly produced by the granulosa cells of the pre-antral (primary and secondary) and small antral follicles (AF’s) in the ovary and shown to be age dependent ( Sahmay et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART)

Umarsingh

Adam

Krishna

2020

PeerJ

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A variety of predictors are available for ovarian stimulation cycles in assisted reproductive technology (ART) forecasting ovarian response and reproductive outcome in women including biomarkers such as anti- Müllerian hormone (AMH). The aim of our present study was to compare the relationship between AMH levels and pregnancy outcomes in patients undergoing intra-cytoplasmic sperm injection (ICSI). Overall, fifty patients (n = 50), aged 20–45 years were recruited for the present prospective study. Three AMH levels were presented with high often poly cystic ovarian syndrome (PCOS) amongst 52.4% patients, 40.5% in normal and 7.1% in low to normal, correspondingly. There was statistically significant relationship between AMH and day of embryo transfer (p < 0.05). The Pearson analysis between AMH, age, E2 and FSH displayed no statistically significant relationship between E2 and AMH (p < 0.05) and negative correlation between FSH and age (p > 0.05). The area under the receiver operating characteristic curve for E2 was 0.725 and for AMH levels as predictors of CPR was 0.497 indicating E2 as better predictor than AMH. The number of oocytes, mature oocytes and fertilized oocytes all presented a weak positive relationship to AMH. Our results confirm the clinical significance of AMH to accurately predict ovarian reserve as a marker and its limitations to use as predictor for a positive pregnancy outcome. Additional prospective studies should be conducted to validate the predictive capability of AMH levels for the outcome of clinical pregnancy.

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Section: Introductionmentioning

confidence: 99%

The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART)

Umarsingh

Adam

Krishna

2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…Manuscript to be reviewed has been projected as a novel marker for predicting ovarian response to gonadotrophin stimulation (Alson et al, 2018, Zargar et al, 2018. AMH is a dimeric glycoprotein strongly produced by the granulosa cells of the pre-antral (primary and secondary) and small antral follicles (AF's) in the ovary and shown to be age dependent (Sahmay et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Peer Review #2 of "The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART) (v0.1)"

2020

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Relationship between follicular fluid and serum anti-Mullerian hormone levels and pregnancy rate in ART cycles

Cited by 2 publications

References 24 publications

The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART)

The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART)

Peer Review #2 of "The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART) (v0.1)"

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