Relationship between five GLUT1 gene single nucleotide polymorphisms and diabetic nephropathy: a systematic review and meta-analysis

Abstract

So far, case-control studies on the association between glucose transporter 1 (GLUT1) gene single nucleotide polymorphisms (SNPs) and diabetic nephropathy (DN) have generated considerable controversy. To clarify the linkage of GLUT1 SNPs on the risk of DN, a systematic review and meta-analysis was performed. A comprehensive literature search of electronic databases was conducted to obtain relative studies. Nine case-control studies were included. Significant differences were found between XbaI SNP (rs841853) and increased risk of DN in all genetic models. Subgroup analyses for Caucasians population and DN from both type 1 and type 2 diabetes also revealed positive results. For Enh2-1 SNP (rs841847), Enh2-2 SNP (rs841848) and HaeIII SNP (rs1385129), obvious linkages were demonstrated in recessive model. However, analysis for the association between HpyCH4V SNP (rs710218) and the susceptibility of DN showed no significance. Likewise, negative outcome was also found in the assessment for the influence of XbaI or Enh2-2 SNP on the pathogenesis progress of DN. The evidence currently available shows that XbaI, Enh2 and HaeIII SNPs, but not HpyCH4V SNP, in GLUT1 gene may be genetic susceptibility to DN. However, data does not support the association between either XbaI or Enh2-2 SNP and the severity of DN.

Association of XbaI <i>GLUT</i>1 Polymorphism with Susceptibility to Type 2 Diabetes Mellitus and Diabetic Nephropathy

“…However, it did not support the association between XbaI and the severity of DN [25]. Nevertheless, (Grzeszczak et al, 2001) study in Caucasians from Poland was not in agreement with all the aforementioned studies and it even suggested that the XbaI (T) allele protects against the development of DN, given that the frequency of the XbaI (GG) genotype increased with each stage of DN.…”

Roles of facilitative glucose transporter GLUT1 in [18F]FDG positron emission tomography (PET) imaging of human diseases

“…Polymorphisms of the GLUT1 gene are associated with susceptibility to diabetic nephropathy in both type 1 and type 2 diabetes [372,[375][376][377]. Skeletal muscle GLUT1 expression and basal leg glucose uptake are reduced in type 2 diabetes [378].…”

Role of nutrient transporters in lifestyle-related diseases

“…In 1988, Li et al reported that a SNP (XbaI polymorphism) was identified in the GLUT1 gene and that there was a difference in allele frequency between diabetic patients and control subjects 6) . Recent studies have demonstrated that XbaI, Enh2 and HaeIII SNPs in the GLUT1 gene may be related to a genetic susceptibility to diabetic nephropathy 7) , and that some SNPs in the GLUT1 gene are involved in the development of non-alcoholic fatty liver disease due to a decrease in the expression of GLUT1 in the liver 8) .…”