Role of nutrient transporters in lifestyle-related diseases

Abstract

Nutrient transporters play significant roles in physiological hormonal and cellular functions as well as in the maintenance of nutrient metabolism. Lifestyle-related disease can be defined as caused by a disturbance in nutrient metabolism as found in diabetes, dyslipidemia, arteriosclerosis, etc. Therefore, deterioration of nutrient transporters by a genetic mutation or abnormal regulation would cause various lifestyle-related diseases. For instance, dysregulation of muscular glucose transport causes hyperglycemia, and impairment of pancreatic glucose transport can be related to inadequate insulin secretion. These deleterious changes in glucose transport can be a cause of diabetes mellitus. Here, we introduce some examples that indicate the relationship between impairment of nutrient transporters and development of lifestylerelated diseases.

The Impacts ofSLC22A1rs594709 andSLC47A1rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients

“…OCTs mediate the interactions between cells and their environment and are involved in transporting a broad spectrum of endogenous substrates and the detoxification of xenobiotics [ 24 ]. Nutrient transporters, including OCT1 and MATE1, could affect nutrient homeostasis through different ways [ 25 ]. Polymorphisms in OCT1 or MATE1 have been correlated with the susceptibility of type 2 diabetes, diabetic nephropathy, hypertension, and primary biliary cirrhosis [ 26 – 28 ].…”