Relationship Between Fcγ Receptor and Interleukin-1 Gene Polymorphisms and Post-treatment Apical Periodontitis

Siqueira, José F.; Rôças, Isabela N.; Provenzano, José C.; Daibert, Frederico K.; Silva, Marlei G.; Lima, Kênio Costa de

doi:10.1016/j.joen.2009.05.006

Cited by 41 publications

(48 citation statements)

References 46 publications

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“…Research works involving the ccomprehension of apical periodontitis mechanisms and the developing of clinical and radiographic signs have emerged in the endodontic literature (39)(40)(41)(42)(43)(44). Morsani et al (41) suggested that the specific genetic markers associated with increased IL-1b production might contribute to apical periodontitis increased susceptibility.…”

Section: Discussionmentioning

confidence: 99%

“…Particularities regarding bacteria including virulence factors such as Porphyromonas gingivalis-FimA genotypes (39), and organization into biofilms (40) are also important factors related to the inflammatory process. Moreover, Siqueira et al (44) reported that polymorphism of Fc-gamma receptor genes might influence the patient's response to endodontic treatment of teeth with apical periodontitis.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between Clinical/Radiographic Features and Inflammatory Cytokine Networks Produced by Macrophages Stimulated with Endodontic Content

Martinho

Chiesa

Leite

et al. 2012

Journal of Endodontics

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation between Clinical/Radiographic Features and Inflammatory Cytokine Networks Produced by Macrophages Stimulated with Endodontic Content

Martinho

Chiesa

Leite

et al. 2012

Journal of Endodontics

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“…Host risk factors such as age, gender, smoking, socioeconomic factors, certain systemic diseases and genetic profile are being studied (12)(13)(14). In this way, several investigations have focused on the identification of SNPs involved with the host response and its ability to generate a deficient immune system (12,(15)(16)(17)(18)(19). Some of these investigations have focused on the TNF-α -308 G>A polymorphism and its association with AP.…”

Section: Introductionmentioning

confidence: 99%

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

et al. 2017

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Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of this study was to perform a systematic review (SR) and metaanalysis to evaluate the association between TNF-α -308 G>A polymorphism and apical periodontitis (AP) phenotypes. A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and VHL (Medline, SciELO, Ibecs, and Lilacs). The MeSH terms "Periapical Periodontitis," "Periapical Abscess," "Polymorphism, Genetic," and "Polymorphism, Single Nucleotide" were used. MeSH synonyms, related terms, and free terms were included. Clinical investigations of individuals with different AP phenotypes in permanent teeth were selected. After application of the eligibility criteria, selected studies were qualified by assessing their methodological quality. A fixed effect model was used for the meta-analysis. The initial search identified 71 references. After excluding duplicate abstracts, 33 were selected. From these, two were eligible for quality assessment and were classified as being of moderate evidence. The included studies did not demonstrate association between AP and TNF-α -308 G>A SNP. However, the meta-analysis demonstrated an association between the genotype distribution and AP phenotype (OR= 0.49; confidence interval= 0.25, 0.96; p=0.04). The role of TNF-α -308 G>A SNP in AP phenotypes is debatable. Further studies are needed to confirm and understand the underlying mechanisms of the identified association.

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“…Sampling and DNA extraction procedures were performed as described previously (4,12). Samples from 45 patients were available from a previous study and stored frozen (4).…”

Section: Sample Taking and Processingmentioning

confidence: 99%

“…Thus far, only a couple of studies have evaluated the relationship between genetic polymorphism and post-treatment apical periodontitis (4,5). Our group investigated the association of Fcg receptor and interleukin (IL)-1 gene polymorphisms with post-treatment apical periodontitis and reported that only carriage of allele H131 of the FcgRIIa gene and a combination of this allele with allele Na2 of the FcgRIIIb gene were found to be associated with persistent disease (4).…”

mentioning

confidence: 99%

Polymorphism of the FcγRIIIa Gene and Post-treatment Apical Periodontitis

Siqueira

Rôças

Provenzano

et al. 2011

Journal of Endodontics

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Relationship Between Fcγ Receptor and Interleukin-1 Gene Polymorphisms and Post-treatment Apical Periodontitis

Cited by 41 publications

References 46 publications

Correlation between Clinical/Radiographic Features and Inflammatory Cytokine Networks Produced by Macrophages Stimulated with Endodontic Content

Correlation between Clinical/Radiographic Features and Inflammatory Cytokine Networks Produced by Macrophages Stimulated with Endodontic Content

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

Polymorphism of the FcγRIIIa Gene and Post-treatment Apical Periodontitis

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