Relationship between extent and complexity of coronary artery disease and different left ventricular geometric patterns in patients with coronary artery disease and hypertension

Abstract

Objective:The relationship between severity of coronary artery disease (CAD) and left ventricler (LV) hypertrophy in hypertensive patients is well known. However, the association between the extent and complexity of CAD assessed with SYNTAX score (SS) and different LV geometric patterns has not been investigated. We aimed to investigate the association between SYNTAX score and different LV geometric patterns in hypertensive patients.Methods:The study had been made in our clinic between January 2013 and August 2013. We studied 251 CAD patients who had hypertension and who underwent coronary angiography (147 males, 104 females; mean age 61.61±9.9 years). Coronary angiography was performed based on clinical indications. SS was determined in all patients. Echocardiographic examination was performed in all subjects. Four different geometric patterns were determined in patients according to LV mass index (LVMI) and relative wall thickness (RWT) (Groups: NG-normal geometry, CR-concentric remodeling, EH-eccentric hypertrophy, and CH-concentric hypertrophy). Biochemical markers were measured in all participants.Results:The highest SS values were observed in the CH group compared with the NG, CR, and EH groups (p<0.05 for all). Also, the SS values of the EH group were higher than in the NG and CR groups (p<0.05 for all). Multivariate linear regression analysis showed that SS was independently associated with LV geometry (β=0.316, p=0.001), as well as age (β=0.163, p=0.007) and diabetes (β=-0.134, p=0.022).Conclusion:SYNTAX score is independently related with LV geometry in hypertensive patients. This result shows that LV remodeling is parallel to the increase in the extent and complexity of CAD in our study patients.

Is SYNTAX Score Predictive of Atrial Fibrillation after On-Pump Coronary Artery Bypass Graft Surgery?

“…COPD, HF, DM and higher SYNTAX score were found to be independent variables predicting the development of POAF. In previous studies, advanced age, male gender, chronic HF, preoperative AF attacks, COPD, chronic renal disease, DM and rheumatic heart disease, metabolic syndrome, and obesity were reported to be preoperative clinical parameters predicting the development of POAF 10)11)…”

“…Kralev et al5) reported that the incidence of CAD was 34% in patients with AF. Several studies have demonstrated a relationship between CAD and POAF 10)11). The SYNTAX score takes into account anatomic complexities including calcification, total occlusion, bifurcation lesions, thrombus, and long lesions.…”

The association of the Syntax score II with carotid intima media thickness and epicardial fat tissue

“…CIMT and EFT are non-invasively and reliably measured parameters that are shown to be closely related to coronary atherosclerosis. 24 , 25 These parameters can be measured with negligible operator dependence, and their reproducibility is excellent. 26 , 27 , 28 That is the reason why we hypothesized that CIMT and EFT are good candidates for further improvement of SSII.…”

The value of the Duke treadmill score in predicting the presence and severity of coronary artery disease

“…It is used in the estimation of long-term outcomes of CAD and in the selection of the treatment modality. Its efficacy has been demonstrated in various studies [7][8][9].…”