Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia

Toscano, Claudia Alvares; Kameyama, Marcia; Garcia-Mijares, Miriam; Silva, Maria Teresa Araújo; Santarem, Érica Maria Machado

doi:10.1016/j.pbb.2008.04.019

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Therefore, this adjunctive behaviour characterised by higher drinking levels could be owing to a higher level of impulsivity. Earlier researches in the literature demonstrated this relationship between different levels of drinking in SIP and other aspects, as differences of strain (Hooks et al 1994;DeCarolis et al 2003) or different susceptibility to addictive behaviour (Mittleman et al 2003;Gilpin et al 2008;López-Grancha et al 2008;Toscano et al 2008). Because of its characteristics of 'excessiveness' and 'persistence', SIP has been proposed as a model of OCD (Woods et al 1993;Woods-Kettelberger et al 1996;Platt et al 2008).…”

Section: Discussionmentioning

confidence: 96%

Impulsivity as Long-Term Sequelae After Chlorpyrifos Intoxication: Time Course and Individual Differences

et al. 2010

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Chlorpyrifos (CPF) is a common organophosphate (OP) insecticide that has been widely used in agriculture as a pesticide. The primary mechanism of acute toxic action of OPs is initiated by acetylcholinesterase (AChE) inhibition. However, non-AChE targets have also been proposed as alternative that contributes to the acute lethal action and side effects of short or long-term exposure. Recently, we have found that a single dose of 250 mg/kg CPF produces acceleration in acquisition on schedule-induced polydipsia (SIP) procedure 6 months after its administration. Moreover, CPF animals show a higher level of impulsivity in a delay-discounting task 1 year after acute administration, and these effects are potentiated when animals are divided into high (HD) and low (LD) drinkers in SIP. In the present study, rats were injected with a subcutaneous (sc) dose of 250 mg/kg of CPF, and 10 weeks later its effect on delay-discounting task was evaluated. Consequently, these animals were evaluated based on SIP, and divided into two populations (HD and LD) according to their rates of drinking in this task. One year after OP administration, these animals were re-evaluated in a delay-discounting task. Results revealed that the CPF-administered rats prefer immediate reward and show a more impulsive choice, 10 weeks after CPF administration. Furthermore, 1 year after it administration, only animals treated with CPF that are high drinkers on SIP are more impulsive than the rest of the groups Therefore, these data suggest that some individuals are more sensitive to OP intoxication than the others, at least in terms of durability of sequelae.

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Section: Discussionmentioning

confidence: 96%

Impulsivity as Long-Term Sequelae After Chlorpyrifos Intoxication: Time Course and Individual Differences

et al. 2010

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“…Moreover, the SIP model seems to be sensitive to detect susceptibilities in individuals to addictive behavior (Gilpin et al, 2008;Mittleman et al, 2003;Toscano et al, 2008) and bingeeating behavior (Moreno et al, 2009). Curiously and relevant to this work, these disorders also share impulsivity as one of the main symptoms (American Psychiatric Association, 2000).…”

Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 99%

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

131

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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“…Furthermore, not all psychiatric patients nor all animals exposed to the SIP paradigm develop compulsive drinking. Such face validity suggests SIP is a powerful pre-clinical tool to help us understand how neurological, environmental, and genetic factors trigger or contribute to this compulsive phenotype (Rosenzweig-Lipson et al, 2007; Toscano et al, 2008; Moreno and Flores, 2012).…”

Section: Dopamine Drives Polydipsia In Humans and Rodentsmentioning

confidence: 99%

The Bed Nucleus of the Stria Terminalis, Homeostatic Satiety, and Compulsions: What Can We Learn From Polydipsia?

Banasikowski

Hawken

2019

Front. Behav. Neurosci.

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A compulsive phenotype characterizes several neuropsychiatric illnesses – including but not limited to – schizophrenia and obsessive compulsive disorder. Because of its perceived etiological heterogeneity, it is challenging to disentangle the specific neurophysiology that precipitates compulsive behaving. Using polydipsia (or non-regulatory water drinking), we describe candidate neural substrates of compulsivity. We further postulate that aberrant neuroplasticity within cortically projecting structures [i.e., the bed nucleus of the stria terminalis (BNST)] and circuits that encode homeostatic emotions (thirst, hunger, satiety, etc.) underlie compulsive drinking. By transducing an inaccurate signal that fails to represent true homeostatic state, cortical structures cannot select appropriate and adaptive actions. Additionally, augmented dopamine (DA) reactivity in striatal projections to and from the frontal cortex contribute to aberrant homeostatic signal propagation that ultimately biases cortex-dependent behavioral selection. Responding becomes rigid and corresponds with both erroneous, inflexible encoding in both bottom-up structures and in top-down pathways. How aberrant neuroplasticity in circuits that encode homeostatic emotion result in the genesis and maintenance of compulsive behaviors needs further investigation.

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Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia

Cited by 7 publications

References 20 publications

Impulsivity as Long-Term Sequelae After Chlorpyrifos Intoxication: Time Course and Individual Differences

Impulsivity as Long-Term Sequelae After Chlorpyrifos Intoxication: Time Course and Individual Differences

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

The Bed Nucleus of the Stria Terminalis, Homeostatic Satiety, and Compulsions: What Can We Learn From Polydipsia?

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