Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population

Yañez-Rivera, Teresa G; Baños-González, Manuel Alfonso; Blé-Castillo, Jorge L.; Torres-Hernández, Manuel Eduardo; Torres-López, Jorge Elías; Borrayo–Sánchez, Gabriela

doi:10.1186/1476-7120-12-35

Cited by 26 publications

(21 citation statements)

References 27 publications

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“…Diastolic dysfunction was represented by E/A ratio and deceleration time. This is in agreement with the recent study of Kocyigit and his colleagues that showed highly significant positive correlation between epicardial fat thickness and these parameters in dialysis patients; age, body mass index, systolic and diastolic blood pressure and CRP [71]. Also in another recent study EpFT measured from parasternal long and short-axis showed statistically significant positive correlation with age (r=0.354, p<0.001; r=0.286, p<0.001 respectively), and waist circumference (r=0.189, p=0.019; r=0.217, p=0.007 respectively) and also significant negative correlation between EpFT from the parasternal long axis with cholesterol-HDL was observed (r=-0.163, p=0.045) [72].…”

Section: Discussionsupporting

confidence: 93%

Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients

Barakat¹

2015

AJIM

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Background: Cardiovascular diseases are common in hemodialysis (HD) patients and cardiovascular mortality is responsible for 50% of overall deaths in these patients. Epicardial fat thickness (EpFT) may be an effective marker for the prediction of cardiovascular diseases in hemodialysis patients. The thickness of EpF can be measured by echocardiography that can accurately estimate the actual amount of EpF. The aim of the current study is to assess the association between EpFT and carotid intima-media thickness (CIMT), left ventricular systolic and diastolic function and left ventricular mass index in patients with chronic kidney disease (CKD) undergoing hemodialysis to clarify the relationships between EpF and cardiovascular disease risk in these patients. Materials and Methods: Forty adult uremic patients from dialysis unit and twenty (age and sex matched) healthy control subjects were included in this study. Clinical evaluation, routine laboratory investigations, echocardiographic study including measurement of EpFT and carotid Duplex to estimate CIMT were done to all subjects. Results: we found highly significant increase in serum C-reactive protein and significant increase in serum phosphorus and triglyceride with significant decrease in serum calcium and high-density lipoprotein cholesterol in hemodialysis patients compared to the controls. Also, there were significant increases in left ventricular mass index, left atrium diameter, carotid intima-media thickness, epicardial fat thickness, peak velocity of the late filling wave due to atrial contraction (A wave) and deceleration time of E wave in hemodialysis patients compared to the controls. There were also highly significant decrease in E/A ratio in hemodialysis patients compared to healthy control subjects. EpFT measured by echocardiography in hemodialysis patients was positively correlated with body mass index, CRP, left atrium diameter, left ventricular mass index, deceleration time and CIMT and negatively correlated with high-density lipoprotein cholesterol and E/A ratio. Conclusion: Hemodialysis patients can be evaluated routinely by echocardiography for early detection of cardiovascular structural and functional changes which are common in these patients and epicardial fat thickness is an effective marker for the prediction of cardiovascular risk in hemodialysis patients.

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Section: Discussionsupporting

confidence: 93%

Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients

Barakat¹

2015

AJIM

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“…[31][32][33] On the other hand, adiponectin, which exerts an antiatherogenic effect via the improvement of endothelial function and the mitigation of inflammation, has been shown to be underexpressed in the EAT of patients who have CAD. 33 In 2014, Yanez-Rivera and colleagues 11 found no significant relationship between echocardiographic EAT thickness and the angiographic severity of CAD. This discrepancy might have resulted from the method used to evaluate CAD severity.…”

Section: Discussionmentioning

confidence: 99%

“…This discrepancy might have resulted from the method used to evaluate CAD severity. Whereas those investigators 11 used the number of stenotic major coronary arteries as the surrogate of CAD severity, we used the Gensini score-a more quantitative method. Furthermore, we evaluated CAD complexity by using Syntax scores and correlating those values with EAT thickness.…”

Section: Discussionmentioning

confidence: 99%

Epicardial Adipose Tissue Thickness Is an Independent Predictor of Critical and Complex Coronary Artery Disease by Gensini and Syntax Scores

Erkan¹,

Tanındı²,

Kocaman³

et al. 2016

Texas Heart Institute Journal

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Epicardial adipose tissue thickness is associated with the severity and extent of atherosclerotic coronary artery disease. We prospectively investigated whether epicardial adipose tissue thickness is related to coronary artery disease extent and complexity as denoted by Gensini and Syntax scores, and whether the thickness predicts critical disease. After performing coronary angiography in 183 patients who had angina or acute myocardial infarction, we divided them into 3 groups: normal coronary arteries, noncritical disease (≥1 coronary lesion with<70% stenosis), and critical disease (≥1 coronary lesion with <70% stenosis). We used transthoracic echocardiography to measure epicardial adipose tissue thickness, then calculated Gensini and Syntax scores by reviewing the angiograms. Mean thicknesses were 4.3 ± 0.9, 5.2 ± 1.5, and 7.5 ± 1.9 mm in patients with normal coronary arteries, noncritical disease, and critical disease, respectively (P <0.001). At progressive thicknesses (<5, 5-7, and >7 mm), mean Gensini scores were 4.1 ± 5.5, 19.8 ± 15.6, and 64.9 ± 32.4, and mean Syntax scores were 4.7 ± 5.9, 16.6 ± 8.5, and 31.7 ± 8.7, respectively (both P <0.001). Thickness had strong and positive correlations with both scores (Gensini, r =0.82, P <0.001; and Syntax, r =0.825, P <0.001). The cutoff thickness value to predict critical disease was 5.75 mm (area under the curve, 0.875; 95% confidence interval, 0.825-0.926; P <0.001). Epicardial adipose tissue thickness is independently related to coronary artery disease extent and complexity as denoted by Gensini and Syntax scores, and it predicts critical coronary artery disease.

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“…1 Obesity, the most important nutritional disorder in industrialized countries, is a prominent risk factor for CAD. 4-6 Evidence shows that some forms of obesity, particularly elevated abdominal adiposity, might be responsible for metabolic disorders and vascular diseases. 4,7,8 The distribution of regional fat, especially the amount of visceral fat around the heart, may affect coronary arteries and the myocardium, 9 which may be considered a predictive factor for cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease

Montazerifar¹,

Bolouri²,

Paghalea³

et al. 2016

Arquivos Brasileiros De Cardiologia

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BackgroundClinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases.ObjectiveThe aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD).MethodsIn a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity.ResultsCAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found.ConclusionsThe findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.

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Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population

Cited by 26 publications

References 27 publications

Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients

Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients

Epicardial Adipose Tissue Thickness Is an Independent Predictor of Critical and Complex Coronary Artery Disease by Gensini and Syntax Scores

Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease

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