Relationship between endothelin and thromboxane A2 in rat liver microcirculation

Kurihara, Toshio; Akimoto, Masumi; Kurokawa, Kaori; Ishiguro, Hisataka; Niimi, Akiko; Maeda, Atushi; Sigemoto, Mutsuo; Yamashita, Katsuko; Yokoyama, Izumi; Hirayama, Yukio; Ihara, Masaki; Yano, Mitsuo

doi:10.1016/0024-3205(92)90166-m

Cited by 31 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endothelin-1 stimulates the production of prostaglandins and thromboxane A 2 from the metabolism of arachidonic acid via cyclooxygenase (Takayasu et al, 1989). Endothelial thromboxane A 2 modulates the response to endothelin-1 of dog basilar artery (Shirahase et al, 1991), rat hepatic vascular bed (Kurihara et al, 1992), and aorta from hypertensive rats (Taddei and Vanhoutte, 1993). Recently, we have reported that the endothelium modulates the response of the rabbit carotid artery to acetylcholine (Miranda et al, 2000a) and 5-hydroxytryptamine (Miranda et al, 2000b) and that of the rabbit renal artery to 5-hydroxytryptamine (Miranda et al, 2002) by releasing both NO and a vasoconstrictor prostanoid.…”

Section: Discussionmentioning

confidence: 99%

Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1

Lloréns

Miranda

Alabadí

et al. 2004

European Journal of Pharmacology

View full text Add to dashboard Cite

The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal or N G -nitro-L-arginine enhanced contractions in response to endothelin-1 only in control arteries, without modifying the endothelin-1 response in diabetic arteries. Indomethacin, furegrelate (thromboxane A 2 inhibitor), or cyclo-(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123; endothelin ET A receptor antagonist) inhibited the contractions in response to endothelin-1, the inhibition being greater in diabetic arteries than in control arteries. 2,6-Dimethylpiperidinecarbonyl-g-methyl-Leu-N in -(methoxycarbonyl)-D-Trp-D-Nle (BQ-788; endothelin ET B receptor antagonist) enhanced the contraction elicited by endothelin-1 in control arteries and displaced to the right the contractile curve for endothelin-1 in diabetic arteries. In summary, diabetes induces hyperreactivity of the rabbit carotid artery to endothelin-1 by a mechanism that at least includes: (1) enhanced activity of muscular endothelin ET A receptors; (2) impairment of endothelin ET B receptor-mediated nitric oxide (NO) release; and (3) enhancement of the production of thromboxane A 2 .

show abstract

Section: Discussionmentioning

confidence: 99%

Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1

Lloréns

Miranda

Alabadí

et al. 2004

European Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…Furthermore, we have reported that NM regulates arachidonate metabolites, especially thromboxaneA2 (TXA2) (Miyagi et al, manuscript submitted). Inhibition of TXA2 synthesis suppresses the liberation of other vasoconstrictive substances and neutrophil infiltration, thereby improving microcirculation [12,261. UTI, which is present in human urine, has two cardinal actions: (1) the suppression of neutrophil elastase (NE) and cathepsin G and (2) the stabilization of lysosomal and cellular membranes [9, 15, 22, 231.…”

Section: Discussionmentioning

confidence: 99%

Successful liver transplantation from agonal non-heart-beating donors in pigs

et al. 2003

View full text Add to dashboard Cite

An effective way to overcome shortage of donors in liver transplantation (LTx) is to consider such from non-heart-beating donors (NHBDs). We investigated how a liver graft should be treated before and/or after procurement for successful LTx from an NHBD. Porcine LTx was performed with FR167653 (FR), a dual inhibitor of tumor necrosis factor-a (TNF-a) and interleukin-1 / 3 (IL-1 p), and/or prostaglandin El (PG). Animals were allocated to an FR group (n = 4, donors and recipients were treated with FR), a PG group (n = 4, donors and recipients were treated with PG), or an FRPG group (n=4, donors and recipients were treated with both FR and PG). No recipients in the FR group and only two of four recipients in the PG group survived, whereas all recipients in the FRPG group survived. Suppression of TNF-a and IL-lp and maintenance of microcirculation are the key to successful transplantation from NHBDs.

show abstract

“…In addition, metabolites in the arachidonic acid cascade are also associated with the deterioration in sinusoidal endothelial cells and coagulopathy of sinusoid. TXA2, which derives from the activation of phospholipase A2, has strong effects of platelets aggregation and vasoconstriction [28] and induces the accumulation of neutrophils in sinusoid [18,39,401. Moreover, TXA2 impairs the microcirculation of the liver directly, and treatment by inhibition of TXA2 production improves the microcirculation after reperfusion in the ischemic liver [32].…”

Section: Discussionmentioning

confidence: 99%

Kupffer cells play an important role in the cytokine production and activation of nuclear factors of liver grafts from non-heart-beating donors

et al. 2002

View full text Add to dashboard Cite

In the non-heart-beating donor (NHBD) deterioration of microcirculation of the liver graft is strongly associated with secretion of cytokines and eicosanoids. In this study we investigated the excretion of cytokines, eicosanoids, and DNA binding activity of transcription factors in the grafts from NHBD and evaluated the effects of the elimination of Kupffer cells on them. The purpose of this study was to clarify the impact of Kupffer cells on transcription factor activity and the that of cytokine and eicosanoid production on reperfusion injury of liver grafts from NHBD. Wistar rats were allocated to four groups: (a) control group: livers were extracted under heart-beating conditions and perfused without cold storage, (b) heart beating (HB) group: livers extracted under heart-beating conditions were perfused after 6 h of cold storage, (c) non-heart-beating (NHB) group: livers extracted after cardiac arrest were perfused after cold storage, (d) Kupffer cell eliminated (KE) group: liposome-encapsulated dichloromethylene diphosphonate was intravenously administered to eliminate Kupffer cells before extraction, and the liver was perfused after cold storage. Cytokines and eicosanoids in perfusate were measured. DNA binding activity of nuclear factor KB, activating protein 1, and nuclear factor-interleukin 6 of tissue were investigated. Concentrations of interleukin lfi and thromboxane B2 in the perfusate were significantly higher in NHB group, but they were completely suppressed in the KE group. A rise in binding activity of nuclear factor KB and activating protein 1 was not observed during cold storage in any groups, but these activities did increase remarkably after reperfusion. Significant buildup of those activities were recognized in the NHB group, and this phenomenon was inhibited in the KE group. The histological structures of the sinusoid in the KE group were well maintained, as with those of the control group. These results indicate that cytokines, eicosanoids, and the DNA binding activity of the transcripton factor are strongly associated with reperfusion injury, and Kupffer cells play an important role in this mechanism in grafts from NHBDs.

show abstract

Relationship between endothelin and thromboxane A2 in rat liver microcirculation

Cited by 31 publications

References 14 publications

Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1

Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1

Successful liver transplantation from agonal non-heart-beating donors in pigs

Kupffer cells play an important role in the cytokine production and activation of nuclear factors of liver grafts from non-heart-beating donors

Contact Info

Product

Resources

About