Relationship between endothelial dysfunction and nocturia with benign prostatic hyperplasia

İnci, Melek; Şarlı, Bahadır; Davarci, Mursel; Yalçınkaya, Fatih Rüştü; Rifaioğlu, Murat Mehmet; Davran, Ramazan; Arıca, Seçil; Motor, Sedat; Demirbaş, Onur

doi:10.3109/21681805.2012.762038

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…Several studies showed the association of LUTS with arterial stiffness using baPWV 5,23 . The current study found that participants in the ΔOABSS > 1 group had a higher arterial stiffness (baPWV ≥ 1400 cm/second) than that found in the control group.…”

Section: Discussionsupporting

confidence: 49%

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

Okamoto

Andô

Jung

et al. 2020

Neurourology and Urodynamics

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Aims To investigate the longitudinal association of microalbuminuria with overactive bladder (OAB). Methods This longitudinal study investigated 561 participants of the Iwaki Health Promotion Project in both 2015 and 2019 in Japan. Microalbuminuria and OAB symptoms were assessed using the urine albuminuria creatinine ratio (ACR) and the overactive bladder symptom score (OABSS), respectively. Urine ACR was defined as high if ≥9.3 mg/gCr. Differences in OABSS between 2015 and 2019 were evaluated as ∆OABSS. Participants were divided into two groups according to ΔOABSS: high (ΔOABSS > 1) and control (≤1). We used baseline data acquired in 2015, such as urine ACR, the Pittsburgh Sleep Quality Index (PSQI), and arterial stiffness expressed by brachial‐ankle pulse wave velocity (baPWV). Predictive factors of a ΔOABSS > 1 were assessed by multivariable logistic regression analysis. Results This study included 332 women and 229 men. Of those, 86 (34 males and 52 females) were classified into the ΔOABSS > 1 group. There were significant group differences in age, renal function, and hemoglobin A1c. Participants in the ΔOABSS > 1 had a higher prevalence of PSQI > 5, baPWV ≥ 1400 seconds/cm, and urine ACR ≥ 9.3 mg/gCr (49% vs 20%, P = .001) than those in the control group. Multivariable analysis revealed that PSQI > 5 (odds ratio [OR], 2.57; 95% confidence interval [CI], 1.15‐4.60; P = .002) and urine ACR ≥ 9.3 mg/gCr (OR, 1.93; 95% CI, 1.15‐3.23; P = .013) were independent risk factors for ΔOABSS > 1. Conclusions Microalbuminuria may be an independent risk indicator for OAB symptom exacerbation.

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Section: Discussionsupporting

confidence: 49%

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

Okamoto

Andô

Jung

et al. 2020

Neurourology and Urodynamics

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“…This means that atherosclerosis may be cross-related with nocturia in middle-aged men. A previous study of patients with BPH showed that the frequency and duration of nocturia were significantly and inversely associated with endothelial dysfunction as measured by flow-mediated dilatation of the brachial artery 27 . As we already reported, 28 nocturia disturbs sleep quality because of interrupted sleep duration.…”

Section: Discussionmentioning

confidence: 57%

Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men

Tsujimura

Hiramatsu

Aoki

et al. 2017

Prostate International

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BackgroundAtherosclerosis is a systematic disease in which plaque builds up inside the arteries that can lead to serious problems related to quality of life (QOL). Lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and late-onset hypogonadism (LOH) are highly prevalent in aging men and are significantly associated with a reduced QOL. However, few questionnaire-based studies have fully examined the relation between atherosclerosis and several urological symptoms.Materials and methodsThe study comprised 303 outpatients who visited our clinic with symptoms of LOH. Several factors influencing atherosclerosis, including serum concentrations of triglyceride, fasting blood sugar, and total testosterone measured by radioimmunoassay, were investigated. We also measured brachial-ankle pulse wave velocity (baPWV) and assessed symptoms by specific questionnaires, including the Sexual Health Inventory for Men (SHIM), Erection Hardness Score (EHS), International Prostate Symptom Score (IPSS), QOL index, and Aging Male Symptoms rating scale (AMS). Stepwise associations between the ratio of measured/age standard baPWV and clinical factors including laboratory data and the scores of the questionnaires were compared using the Jonckheere–Terpstra test for trend. The associations between the ratio of measured/age standard baPWV and each IPSS score were assessed in a multivariate linear regression model after adjustment for serum triglyceride, fasting blood sugar, and total testosterone.ResultsRegarding ED, a higher level of the ratio of measured/age standard baPWV was associated with a lower EHS, whereas no association was found with SHIM. Regarding LUTS, a higher ratio of measured/age standard baPWV was associated with a higher IPSS and QOL index. However, there was no statistically significant difference between the ratio of measured/age standard baPWV and AMS. A multivariate linear regression model showed only nocturia to be associated with the ratio of measured/age standard baPWV for each IPSS score.ConclusionAtherosclerosis is associated with erectile function and LUTS, especially nocturia.

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“…The endothelial cells mediate the local vascular tone as well as the major facets of the atherosclerotic process that result in coronary artery disease, stroke, and erectile dysfunction [22]. A recent publication further confirmed that there was a negative correlation between brachial flow-mediated dilatation and frequency of nocturia (r = −0.879, P < 0.0001) in patients with benign prostatic hyperplasia [23].…”

Section: Discussionmentioning

confidence: 87%

Nocturia indicates a poor health status and increases mortality in male patients with type 2 diabetes mellitus

et al. 2016

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Relationship between endothelial dysfunction and nocturia with benign prostatic hyperplasia

Abstract: In patients with BPH, nocturia is associated with endothelial dysfunction and may be an insidious risk factor for cardiovascular disease.

Cited by 13 publications

References 31 publications

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men

Nocturia indicates a poor health status and increases mortality in male patients with type 2 diabetes mellitus

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