Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos

Richter, Kevin S.; Bugge, K.; Bromer, Jason G.; Levy, Michael J.

doi:10.1016/j.fertnstert.2006.05.064

Cited by 286 publications

(217 citation statements)

References 34 publications

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“…A number of studies have indicated a higher pregnancy rate at a partic- ular endometrial thickness (29)(30)(31)(32)(33), while alternative studies indicated no significant correlation between endometrial thickness and pregnancy rates in IVF/ICSI patients (34)(35)(36)(37)(38)(39). The present study indicated that clinical pregnancy rates following embryo transfer are positively correlated with endometrial thickness, which is consistent with previous studies (39)(40)(41).…”

Section: Discussionsupporting

confidence: 88%

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Yin

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the association between follicular fluid (FF) levels of high-mobility group box 1 (HMGB1) protein and the reproductive outcome in patients undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). FF samples were collected from the ovarian follicles (≥14 mm) of 143 infertile patients that had undergone IVF/ICSI, and the HMGB1 expression levels were determined using ELISA. Spearman's correlation and receiver operating characteristic (ROC) curve analysis were applied to analyze the results. Significantly increased levels of HMGB1 protein (7.38±2.02 vs. 6.14±2.52 ng/ml; P<0.01), endometrial thickness on the day of human chorionic gonadotropin (hCG) administration (10.3±1.3 vs. 9.7±1.7 mm; P<0.01) and retrieved oocyte counts (11.68±6.51 vs. 11.00±6.34; P<0.01) were observed in the pregnant group when compared with the non-pregnant group. Conversely, the level of luteinizing hormone on the day of hCG administration was significantly reduced in the pregnant group compared with the non-pregnant group (0.92±1.78 vs. 1.78±2.03 pmol/l, P<0.01). The ROC curve indicated a significant association between the FF level of HMGB1 protein and the pregnancy rate, with an area under the ROC curve of 0.673 (0.581-0.765; P<0.01). In addition, the HMGB1 protein level was shown to have a significant positive correlation with the endometrial thickness (r=0.170; P<0.05). Therefore, the present study indicated that the FF levels of HMGB1 protein are increased in pregnant patients and are positively correlated with endometrial thickness. Thus, FF levels of HMGB1 may be a useful factor for predicting the outcome of IVF/ICSI treatments.

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Section: Discussionsupporting

confidence: 88%

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Yin

et al. 2015

Experimental and Therapeutic Medicine

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“…Endometrial thickness has been reported to be one of the most important factors for success in ART. Zhang et al [12] reported a significant difference in the pregnancy rate in patients with an endometrial thickness above and below 9 mm, whereas Kovacs et al [13] and Richter et al [14] showed a gradual increase in the implantation rate with increasing endometrial thickness. In the present study, none of the patients whose endometrial thickness was <7 mm achieved a live-birth (data not shown).…”

Section: Discussionmentioning

confidence: 99%

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

Fujimoto

Ichinose

Harada

et al. 2014

J Assist Reprod Genet

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Purpose To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH). Methods The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed. Results There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth. Conclusions Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.

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“…Women with thin endometria have lower pregnancy rates, largely related to implantation failure 1, 2, 3, 4, 5, 6. The authors recently found high blood impedance in the uterine radial artery in patients with a thin endometrium4 and that vitamin E, L‐arginine, and sildenafil citrate treatments, which increase the blood flow of the uterine radial artery, helped to thicken the endometrium 7.…”

Section: Introductionmentioning

confidence: 99%

Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure

Maekawa

Tanaka

Mihara

et al. 2017

Reprod Medicine & Biology

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AimAlthough a thin endometrium has been well recognized as a critical factor in implantation failure, little information is available regarding the molecular mechanisms. The present study investigated these mechanisms by using genome‐wide mRNA expression analysis.MethodsThin and normal endometrial tissue was obtained from a total of six women during the mid‐luteal phase of the menstrual cycle. The transcriptomes were analyzed with a microarray. Differentially expressed genes were classified according to Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways.ResultsThe study identified 318 up‐regulated genes and 322 down‐regulated genes in the thin endometrium, compared to the control endometrium. The GO and KEGG pathway analyses indicated that the thin endometrium possessed aberrantly activated immunity and natural killer cell cytotoxicity that was accompanied by an increased number of inflammatory cytokines, such as IFN‐γ. Various genes that were related to metabolism and anti‐oxidative stress were down‐regulated in the thin endometrium.ConclusionImplantation failure in the thin endometrium appears to be associated with an aberrantly activated inflammatory environment and aberrantly decreased response to oxidative stress.

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Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos

Cited by 286 publications

References 34 publications

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure

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