Relationship between dyslipidaemia and semen quality and serum sex hormone levels: an infertility study of 167 Japanese patients

Hagiuda, Jun; Ishikawa, Hiromichi; Furuuchi, Toshi; Hanawa, Yoshinori; Marumo, Ken

doi:10.1111/and.12057

Cited by 32 publications

(27 citation statements)

References 26 publications

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“…However, it was a surprise that serum lipids levels such as TC, TG, LDL and HDL were almost unrelated to semen parameters except only slightly correlations between serum TG and HDL levels and semen volume, and between serum FFA level and sperm motility. This observation was similar to the results reported by Hagiuda and colleagues [ 30 ].…”

Section: Discussionsupporting

confidence: 93%

Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men

et al. 2016

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ObjectiveThis prospective study was designed to investigate the relationship between lipids levels in both serum and seminal plasma and semen parameters.Methods631 subfertile men were enrolled. Their obesity-associated markers were measured, and semen parameters were analyzed. Also, seminal plasma and serum TC, TG, HDL and LDL and serum FFA, FSH, LH, total testosterone (TT), estradiol (E2) and SHBG levels were detected.ResultsSeminal plasma and serum TG, TC and LDL levels were positively related to age. Serum TC, TG and LDL were positively related to obesity-associated markers (P < 0.001), while only seminal plasma TG was positively related to them (P < 0.05). For lipids levels in serum and seminal plasma, only TG level had slightly positive correlation between them (r = 0.081, P = 0.042). There was no significant correlation between serum lipids levels and semen parameters. However, seminal plasma TG, TC, LDL and HDL levels were negatively related to one or several semen parameters, including semen volume (SV), sperm concentration (SC), total sperm count (TSC), sperm motility, progressive motility (PR) and total normal-progressively motile sperm counts (TNPMS). Moreover, seminal plasma TG, TC, LDL and HDL levels in patients with oligospermatism, asthenospermia and teratozoospermia were higher than those with normal sperm concentration, motility or morphology. After adjusting age and serum LH, FSH, TT, E2 and SHBG levels, linear regression analysis showed that SV was still significantly correlated with seminal plasma LDL (P = 0.012), both of SC and TSC with seminal plasma HDL (P = 0.028 and 0.002), and both of PR and sperm motility with seminal plasma TC (P = 0.012 and 0.051).ConclusionThe abnormal metabolism of lipids in male reproductive system may contribute to male factor infertility.

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Section: Discussionsupporting

confidence: 93%

Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men

et al. 2016

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“…In the present study, we found, apart from an inverse correlation between (free) T and SAT cell size in univariate analyses, an inverse association of (free) T levels with TG and insulin sensitivity (HOMA-IR). Inverse associations between T levels and TG are consistent with the findings of previous studies [ 29 , 30 ]. Elevated circulating TG levels have been suggested to be an indicator of metabolic derangement, associated with both glucose intolerance and increased amounts of VAT [ 31 – 33 ].…”

Section: Discussionsupporting

confidence: 92%

Determinants of testosterone levels in human male obesity

et al. 2015

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Testosterone (T) levels are decreased in obese men, but the underlying causes are incompletely understood. Our objective was to explore the relation between low (free) T levels and male obesity, by evaluating metabolic parameters, subcutaneous adipose tissue (SAT) aromatase expression, and parameters of the hypothalamic–pituitary–gonadal axis. We recruited 57 morbidly obese men [33 had type 2 diabetes (DM2)] and 25 normal-weight men undergoing abdominal surgery. Fourteen obese men also attended a follow-up, 2 years after gastric bypass surgery (GBS). Circulating T levels were quantified by LC–MS/MS, whereas free T levels were measured using serum equilibrium dialysis and sex hormone-binding globulin, luteinizing hormone, and follicle-stimulating hormone by immunoassay. SAT biopsies were used to determine adipocyte cell size and aromatase expression by real-time PCR. Total and free T levels were decreased in obese males versus controls, with a further decrease in obese men with DM2 versus obese men without DM2. There were no differences in aromatase expression among the study groups, and sex steroids did not correlate with aromatase expression. Pearson analysis revealed an inverse association between (free) T and SAT cell size, triglycerides, and HOMA-IR. Multivariate analysis confirmed the inverse association between (free) T and SAT cell size (β = −0.321, P = 0.037 and β = −0.441, P = 0.011, respectively), independent of age, triglycerides, HOMA-IR, obesity, or diabetes. T levels were normalized 2 years after GBS. These data suggest that SAT cell size rather than SAT aromatase expression or parameters of the hypothalamic–pituitary–gonadal axis is related to low T in male obesity, which points to adipose cell size-related metabolic changes as a major trigger in decreased T levels.

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“…In the last years, growing evidence has linked abdominal obesity, insulin resistance and dyslipidemia to male infertility (Kasturi et al ., ; Morrison & Brannigan, ). Several studies suggest that alterations in lipid metabolism may affect semen quality and fertility (Shalaby et al ., ; Saez Lancellotti et al ., ; Bobjer et al ., ; Hagiuda et al ., ). In this context, the model of diet‐induced obesity in rats has been recently used to investigate sperm dysfunction (Ferramosca et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Dietary fatty acids influence sperm quality and function

et al. 2017

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Recently, obesity has been linked to male infertility. In animal models the administration of a high-fat diet caused a reduction in sperm quality, by impairing gamete energy metabolism. The aim of this study was to investigate a possible effect of dietary fatty acids supplementation in the modulation of sperm energy metabolism and, in turn, in the improvement of sperm quality in rats fed a high-fat diet. Sexually mature male Sprague-Dawley rats were divided into four groups and fed for 4 weeks a standard diet (control group), a high-fat diet (enriched in 35% of fat and 15% sucrose), a high-fat diet supplemented with 2.5% olive oil (a source of monounsaturated fatty acids) or a high-fat diet supplemented with 2.5% krill oil (a source of n-3 polyunsaturated fatty acids). Liver and adipose tissue weight, plasma glucose, insulin and lipid concentrations were determined. Activities of enzymes involved in sperm energetic metabolism were evaluated by spectrophotometric assays. Sperm mitochondrial respiratory efficiency was also assayed. The obtained results suggest that olive oil partially counteracts the negative effects of a high-fat diet on sperm quality, by increasing gamete motility, by reducing oxidative stress and slightly improving mitochondrial respiration efficiency. On the other hand, krill oil determines an increase in sperm concentration and motility, an increase in the activities of lactate dehydrogenase, Krebs cycle enzymes and respiratory chain complexes; a parallel increase in the cellular levels of ATP and a reduction in oxidative damage were also observed. These results suggest that dietary fatty acids are able to positively influence sperm quality and function.

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Relationship between dyslipidaemia and semen quality and serum sex hormone levels: an infertility study of 167 Japanese patients

Cited by 32 publications

References 26 publications

Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men

Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men

Determinants of testosterone levels in human male obesity

Dietary fatty acids influence sperm quality and function

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