Dietary fatty acids influence sperm quality and function

Ferramosca, Alessandra; Moscatelli, Natalina; Giacomo, Mariangela Di; Zara, Vincenzo

doi:10.1111/andr.12348

Cited by 50 publications

(53 citation statements)

References 46 publications

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“…In conclusion, we show that dietary lipids affect sperm function, especially sperm metabolism, in D. melanogaster, as in vertebrates (Ferramosca, Moscatelli, Giacomo, & Zara, 2017). Future studies will have to genetically target those enzymes in Drosophila that were activated in mice after PUFA supplementation (Ferramosca et al, 2017): sperm enzymes involved in glycolysis, tricarboxylic acid cycle and the respiration chain and that reduce oxidative damage and explore the exciting dynamics of dietary lipid uptake and fertility in the wild.…”

Section: Discussionmentioning

confidence: 83%

Dietary polyunsaturated fatty acids affect volume and metabolism of Drosophila melanogaster sperm

Guo

Reinhardt

2020

J of Evolutionary Biology

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Dietary fatty acids can accumulate in sperm and affect their function in vertebrates. As Drosophila melanogaster shares several pathways of lipid metabolism and shows similar lipid‐dependent phenotypes but lacks some hormones that in vertebrates regulate lipid metabolism, there is currently no clear prediction as to how dietary fatty acids affect the sperm of D. melanogaster. We manipulated the amount and identity of dietary polyunsaturated fatty acids (PUFA) in the food of D. melanogaster males (a treatment known to affect membrane fluidity) and measured changes in sperm parameters. We found that (a) males reared on food containing PUFA‐rich, plant‐derived lipids showed a slower increase in sperm volume over male age compared to males reared on yeast‐derived lipid food which is richer in saturated fatty acids. (b) The resistance of sperm membrane integrity to osmotic stress was not altered by dietary lipid treatment, but (c) food containing yeast‐derived lipids induced a 46% higher in situ rate of production of reactive oxygen species in sperm cells. These findings show that dietary lipids have similar effects on sperm parameters in Drosophila as in vertebrates, affect some, but not all, sperm parameters and modulate male reproductive ageing. In concert with recent findings of sex‐specific seasonal variation of diet choice in the wild, our results suggest a substantial dietary impact on the dynamics of male reproduction in the wild.

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Section: Discussionmentioning

confidence: 83%

Dietary polyunsaturated fatty acids affect volume and metabolism of Drosophila melanogaster sperm

Guo

Reinhardt

2020

J of Evolutionary Biology

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“…Moreover, KO has the ability to improve lipid and glucose metabolism, exerting possible protective effects against the negative effects caused by a high‐fat diet supplementation . Interestingly, KO administration caused a strong increase in sperm concentration and motility in comparison to high‐fat fed rats . The same study revealed that fatty acid composition of the diet influenced sperm metabolism, by restoring the activity of enzymes involved in sperm bioenergetics pathways.…”

Section: Effects Of Pufa On Sperm Quality and Functionmentioning

confidence: 87%

“…Interestingly, the fat intake increment promotes sperm cell damage, but not the OO intake alone . On the contrary, fat, and OO intake simultaneously recovers normal sperm physiology . In particular, OO supplementation significantly increased sperm motility, without affecting serum glycemic profile and fat distribution observed in high‐fat fed animals.…”

Section: Effects Of Mufa On Sperm Quality and Functionmentioning

confidence: 94%

“…Although olive oil was positively associated with BMI, recent studies carried out in rodents and in rabbits suggested that the addition of OO to a high‐fat diet counteracted the negative effects of a high‐fat diet on sperm quality and function . Interestingly, the fat intake increment promotes sperm cell damage, but not the OO intake alone .…”

Section: Effects Of Mufa On Sperm Quality and Functionmentioning

confidence: 97%

“…In particular, OO supplementation significantly increased sperm motility, without affecting serum glycemic profile and fat distribution observed in high‐fat fed animals. The improvement of sperm quality was also associated to a reduction of oxidative stress and to an increase in mitochondrial respiration efficiency . The biological implications of a mitochondrial chain impairment (after a high‐fat diet administration) or improvement (after a high‐fat diet supplementation with OO) result in different ATP concentrations in sperm cells from animals fed the different experimental diets …”

Section: Effects Of Mufa On Sperm Quality and Functionmentioning

confidence: 99%

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Obesity and Male Infertility: Role of Fatty Acids in the Modulation of Sperm Energetic Metabolism

Ferramosca

Giacomo

Moscatelli

et al. 2018

Euro J Lipid Sci & Tech

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Obesity in men of reproductive age is increasing worldwide, impacting negatively on reproductive potential, sperm function, and assisted reproduction outcomes. Changes in modern eating behaviors are needed to invert the negative correlation between lifestyle and sperm quality. It is known from the literature that fatty acids are able to modulate lipid metabolism by complex mechanisms involving a sequence of interdependent and cross‐regulated molecular events. Although a great deal of data is currently available on the dietary modulation of lipid metabolism, little is known about the nutritional regulation of sperm energetic metabolism. In this review, major data from the literature about the role of some dietary fats as modulators of sperm function and quality are described. Moreover, biochemical mechanisms responsible for an impairment or improvement in sperm bioenergetics are critically analyzed. It is noteworthy that both quantitative and qualitative aspects of dietary fats influence sperm function. The administration of a high‐fat diet, low in polyunsaturated fatty acids, caused a significant increase in body weight hyperglycemia, hyperinsulinemia, and dyslipidemia, along with a significant reduction in sperm quality. In contrast, unsaturated fatty acids are able to positively influence sperm quality and function. The understanding of the biochemical mechanisms underlying the development of male infertility related to obesity led us to depict a possible framework for the molecular action of fatty acids on sperm quality during dysmetabolic conditions. Practical Applications: In this review major data from the literature about the spermatozoa targeting of dietary fatty acids are described and critically analyzed, because now dietary fatty acids are the current focus of research in the field of nutrition and reproduction in males. Such knowledge will eventually translate into the development of new attractive therapeutic approaches for male infertility related to alterations in lipid metabolism. Dietary fatty acids are involved in the nutritional modulation of sperm energetic metabolism. Diets rich in saturated fatty acids (SFA) and low in polyunsaturated fatty acids (PUFA) seem to correlate with defective sperm energy metabolism and reduced sperm quality. Administration of PUFA, especially n‐3 PUFA, determines an increase in sperm concentration, and motility, associated to an increase in the activities of mitochondrial enzymes involved in gamete energetic metabolism and to a reduction in oxidative damaeg

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Obesity‐induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality

et al. 2023

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Obesity is a systemic metabolic disease that can induce male infertility or subfertility through oxidative stress. The aim of this study was to determine how obesity impairs sperm mitochondrial structural integrity and function, and reduces sperm quality in both overweight/obese men and mice on a high‐fat diet (HFD). Mice fed the HFD demonstrated higher body weight and increased abdominal fat content than those fed the control diet. Such effects accompanied the decline in antioxidant enzymes, such as glutathione peroxidase (GPX) and catalase and superoxide dismutase (SOD) in testicular and epidydimal tissues. Moreover, malondialdehyde (MDA) content significantly increased in sera. Mature sperm in HFD mice demonstrated higher oxidative stress, including increased mitochondrial reactive oxygen species (ROS) levels and decreased protein expression of GPX1, which may impair mitochondrial structural integrity and reduce mitochondrial membrane potential (MMP) and ATP production. Moreover, cyclic AMPK phosphorylation status increased, whereas sperm motility declined in the HFD mice. Clinical studies demonstrated that being overweight/obese reduced SOD enzyme activity in the seminal plasma and increased ROS in sperm, accompanied by lower MMP and low‐quality sperm. Furthermore, ATP content in the sperm was negatively correlated with increases in the BMI of all clinical subjects. In conclusion, our results suggest that excessive fat intake had similar disruptive effects on sperm mitochondrial structure and function, as well as oxidative stress levels in humans and mice, which in turn induced lower sperm motility. This agreement strengthens the notion that fat‐induced increases in ROS and impaired mitochondrial function contribute to male subfertility.

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Dietary fatty acids influence sperm quality and function

Cited by 50 publications

References 46 publications

Dietary polyunsaturated fatty acids affect volume and metabolism of Drosophila melanogaster sperm

Dietary polyunsaturated fatty acids affect volume and metabolism of Drosophila melanogaster sperm

Obesity and Male Infertility: Role of Fatty Acids in the Modulation of Sperm Energetic Metabolism

Obesity‐induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality

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