Relationship Between Dose Size and Dose Interval of Polyinosinic-Polycytidylic Acid and Interferon Hyporesponsiveness in Mice

duBuy, H. G.; Johnson, Martin L.; Buckler, Charles E.; Baron, Samuel

doi:10.3181/00379727-135-35047

Cited by 25 publications

(10 citation statements)

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“…Treatment with either In .Cn or interferon beginning on Day 3 did not result in significant reduction in mortality (Table 111). Treatment with In.Cn was not continued beyond 2 days since hyporesponsiveness of continued interferon production occurs after 2 days of treatment (10). Treatment with interferon (lo4 units daily for 5 days) beginning on Days 3 and 4 gave erratic protection in preliminary experiments.…”

Section: Postinfection Treatment With a R A -A Of Hvh-infected Mice mentioning

confidence: 96%

Comparative Effectiveness of Six Antiviral Agents in Herpes Simplex Type I Infection of Mice

Lefkowitz

Worthington

Conliffe

et al. 1976

Experimental Biology and Medicine

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Section: Postinfection Treatment With a R A -A Of Hvh-infected Mice mentioning

confidence: 96%

Comparative Effectiveness of Six Antiviral Agents in Herpes Simplex Type I Infection of Mice

Lefkowitz

Worthington

Conliffe

et al. 1976

Experimental Biology and Medicine

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“…Polyriboinosinic acid * polyribocytidylic acid [poly(I) poly(C)I is effective as an interferon inducer in rodents (3)(4)(5)(6)14), but not in cattle, humans, or subhuman primates (7,13). Failure of poly(I) * poly(C) to induce interferon in these latter species has been ascribed to the action of a serum nucleolytic enzyme, which inactivates the compound (10,11).…”

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confidence: 99%

Interferon Induction in Cynomolgus and Rhesus Monkeys After Repeated Doses of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex

Sammons

Stephen

Levy

et al. 1977

Antimicrob Agents Chemother

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Serum interferon activity was determined in 12 cynomolgus and 12 rhesus monkeys injected intravenously once daily for 10 days with from 0.1 to 6.0 mg of a stabilized polyriboinosinic acid · polyribocytidylic acid complex per kg, composed of polyriboinosinic acid · polyribocytidylic acid, poly-1-lysine, and carboxymethylcellulose [poly(ICLC)]. Interferon activity was detected 2 h after the first injection, with maximum activity occurring 8 h after the second injection. A period of hyporesponsiveness occurred after the third injection of poly(ICLC) in all monkeys and lasted until the sixth injection in the rhesus monkeys, when interferon activity again became more elevated. The delayed rebound was not as apparent in cynomolgus monkeys. Rhesus monkeys injected with 6 mg/kg did not exhibit serious side effects.

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“…In Wistar rats, a-IFN induction by poly I:C is significantly reduced from weeks 2 to 3. This relative hyporesponsive state to repeated doses of poly I:C has been demonstrated previously in mice (26,27) and humans (28), but not in rats.…”

Section: Discussionmentioning

confidence: 58%

Poly I:C Induction of α-Interferon in the Diabetes-Prone BB and Normal Wistar Rats: Dose-Response Relationships

et al. 1994

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Although the administration of a fixed dose of the alpha-interferon (alpha-IFN) inducer, polyinosinic polycytidilic acid (poly I:C), accelerates the development of diabetes in DP-BB rats, no reports have characterized the dose-response relationship of poly I:C with serum alpha-IFN levels and the development of diabetes. This study examines the dose-response relationships of poly I:C with the induction of serum alpha-IFN and the development of diabetes in DP-BB and normal Wistar rats. Also tested in this study is the hypothesis that the lack of development of diabetes in poly I:C-treated normal Wistar rats is attributable to a deficient alpha-IFN response. Using poly I:C doses of 0.5, 1.5, 5, and 10 micrograms/g body weight, a direct dose-response relationship was observed in DP-BB rats with the serum alpha-IFN response. Moreover, all doses of poly I:C accelerated the onset of diabetes in BB rats. Serum alpha-IFN levels inversely correlated with time of onset of diabetes (P < 0.01). Also, BB rats with higher levels of serum alpha-IFN were associated with earlier onset of diabetes (P < 0.001). Poly I:C-induced serum alpha-IFN levels were significantly lower in diabetic than in nondiabetic BB rats. In normal Wistar rats, although all doses of poly I:C significantly increased serum alpha-IFN levels, diabetes was not induced. The results of this study indicate that poly I:C administration elevates serum alpha-IFN and accelerates the development of diabetes in BB rats at even very low doses.(ABSTRACT TRUNCATED AT 250 WORDS)

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Relationship Between Dose Size and Dose Interval of Polyinosinic-Polycytidylic Acid and Interferon Hyporesponsiveness in Mice

Cited by 25 publications

References 0 publications

Comparative Effectiveness of Six Antiviral Agents in Herpes Simplex Type I Infection of Mice

Comparative Effectiveness of Six Antiviral Agents in Herpes Simplex Type I Infection of Mice

Interferon Induction in Cynomolgus and Rhesus Monkeys After Repeated Doses of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex

Poly I:C Induction of α-Interferon in the Diabetes-Prone BB and Normal Wistar Rats: Dose-Response Relationships

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