Comparative Effectiveness of Six Antiviral Agents in Herpes Simplex Type I Infection of Mice

Swine Influenza Virus Vaccine: Potentiation of Antibody Responses in Rhesus Monkeys

“…These data have not been extended to other species, and the dose was at least 100fold greater than the minimal effective 1290 dose of poly(ICLC) used in the present studies. Lefkowitz et al (9) recently showed that nontoxic doses of adenine arabinoside and a poly(I) poly(C) given in combination resulted in synergistic mortality in mice; their dose of poly(I)-poly(C') was approximately 50fold greater than the minimal effective adjuvant dose of poly(ICLC) in our study. Possible adverse drug interactions with other medications that might 'be used on a routine basis in patients, such as coumarin anticoagulants,' cardioglycosides, or other compounds, must be considered with any clinical use of this compound.…”

Treatment of Experimental Herpesvirus Infections with Phosphonoformate and Some Comparisons with Phosphonoacetate

“…The compound has been less effective, however, when administered systemically to HSV-or MCMV-infected animals (1,2,(7)(8)(9)11). Because PA accumulates in the bone of a variety of experimental animals it has not been considered for use in humans (B.…”

Chemotherapy of Viral Infections

“…However, although interferon inhibits herpesvirus synergistically with adenine arabinoside (ara-A) in cell cultures (LERNER and BAILEY 1974), no such synergism was observed in mice (LEFKOWITZ et al 1976). Ammonium 5-tungsto-2-antimonate (HPA 23) partially protects mice against encephalomyocarditis virus or vesicular stomatitis virus ).…”