Relationship Between Depression and Pancreatic Cancer in the General Population

Carney, Caroline P.; Jones, Laura; Woolson, Robert F.; Noyes, Russell; Doebbeling, Bradley N.

doi:10.1097/01.psy.0000088588.23348.d5

Cited by 69 publications

(45 citation statements)

References 42 publications

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“…Pancreatic cancer is one of the most dismal prognoses among cancers and it was previously reported that patients with pancreatic cancer develop depressive symptoms at high rates (32,33). In addition, whereas patients with esophageal cancer had a high proportion of delirium, this was not mentioned in previous reports and might just have been due to the small number of cases in this study.…”

contrasting

confidence: 52%

Psychiatric Disorders in Cancer Patients at a University Hospital in Japan: Descriptive Analysis of 765 Psychiatric Referrals

Tada

Matsubara

Kawada

et al. 2012

Japanese Journal of Clinical Oncology

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Objective: In cancer patients, adjustment disorders, delirium and depression have been identified as common psychiatric disorders. Although a comparable result was reported in the National Cancer Center in Japan, the nature of patients in that hospital may differ from that in local hospitals. There is a possibility to expand the findings of psycho-oncology by evaluation of the data from a local university hospital and comparison with the National Cancer Center data. Methods: We retrospectively reviewed the medical records of cancer patients who were referred to the Department of Psycho-Oncology at Saitama Medical University International Medical Center. We identified their characteristics and psychiatric diagnoses and compared these with the National Cancer Center data. Results: During the study period, 765 cancer patients were referred. The numbers of inpatients and outpatients were almost the same. The most common psychiatric diagnosis was adjustment disorders (24%), followed by delirium (16%) and then major depressive disorder (12%). The rank of these three was the same as that at the National Cancer Center. Outpatients constituted more than 80% of the patients with major depressive disorder. The proportion of cancer patients with schizophrenia in this study (4.3%) was higher than that in the National Cancer Center (1.6%). Conclusions: This study revealed basic information about the consultation data of cancer patients at a local university hospital in Japan. The importance of communication with outpatients was suggested. It seems that cancer treatment for patients with schizophrenia in a local hospital is also important.

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contrasting

confidence: 52%

Psychiatric Disorders in Cancer Patients at a University Hospital in Japan: Descriptive Analysis of 765 Psychiatric Referrals

Tada

Matsubara

Kawada

et al. 2012

Japanese Journal of Clinical Oncology

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“…Later, several studies confirmed depression as a prodrome of this disease [23,24,25,26]. Depressive symptoms occurred as first symptoms in about 38-45% of patients with carcinoma of the pancreas, while anxiety in the prodromal phase was observed in about 12% [24].…”

Section: Resultsmentioning

confidence: 99%

Mood and Anxiety Disorders as Early Manifestations of Medical Illness: A Systematic Review

Cosci

Fava²,

Sonino³

2014

Psychother Psychosom

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Background: Affective disturbances involving alterations of mood, anxiety and irritability may be early symptoms of medical illnesses. The aim of this paper was to provide a systematic review of the literature with qualitative data synthesis. Methods: MEDLINE, PsycINFO, EMBASE, Cochrane, and ISI Web of Science were systematically searched from inception to February 2014. Search terms were ‘prodrome/early symptom', combined using the Boolean ‘AND' operator with ‘anxiety/depression/mania/hypomania/irritability/irritable mood/hostility', combined with the Boolean ‘AND' operator with ‘medical illness/medical disorder'. PRISMA guidelines were followed. Results: A total of 21 studies met the inclusion criteria and were analyzed. Depression was found to be the most common affective prodrome of medical disorders and was consistently reported in Cushing's syndrome, hypothyroidism, hyperparathyroidism, pancreatic and lung cancer, myocardial infarction, Wilson's disease, and AIDS. Mania, anxiety and irritability were less frequent. Conclusions: Physicians may not pursue medical workup of cases that appear to be psychiatric in nature. They should be alerted that disturbances in mood, anxiety and irritability may antedate the appearance of a medical disorder.

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“…Kelsen et al [19] evaluated depression in 131 patients with newly diagnosed pancreatic cancer and found that 38% of patients had high levels of depression. In 2003, Carney et al [20] reported that 71% of pancreatic cancer patients were subject to depression; moreover, pancreatic cancer was also diagnosed more commonly than other gastrointestinal malignancies in patients with preexisting depression. However, in 2006, a study by Sheibani-Rad and Velanovich [21] based on 258 patients with pancreatic cancer showed that the incidence of depression was just 20%.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Incidence of Pancreatic Cancer-Related Depression and Its Relationship with the Quality of Life of Patients

et al. 2010

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Aim: To investigate the incidence of pancreatic cancer-related depression and the relationship between symptoms of depression and the quality of life (QoL) of patients. Methods: 262 inpatients with cancer of the digestive system (pancreatic cancer, liver cancer, esophageal cancer, gastric cancer, and colorectal cancer) from four Guangzhou hospitals were enrolled into the study between June 2007 and June 2009. The Hamilton Rating Scale for Depression-24 questionnaire was used to assess the degree of depression. QoL of all patients was evaluated by EORTC QLQ-C30. Additionally, EORTC QLQ-PAN-26 was used for patients with pancreatic cancer. Results: The incidence of depression among pancreatic cancer patients was significantly higher than among other digestive cancers. More pancreatic cancer patients suffered severe depression than those with liver cancer and gastric cancer. Compared with other groups with depression, QoL of pancreatic cancer patients in each functioning scale was significantly worse, while the symptoms of fatigue and pain were significantly severe. QoL of pancreatic cancer patients with depression in role, emotional, and social functioning were sharply poorer than those without depression. The symptoms of fatigue, pain and appetite loss in cancer patients with depression were significantly more frequent than those without depression. Conclusion: Compared with other cancers of the digestive system, depressive symptoms are common psychological disturbances in pancreatic cancer patients. Moreover, depression significantly lowers QoL in pancreatic cancer patients.

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Relationship Between Depression and Pancreatic Cancer in the General Population

Abstract: Depression and pancreatic cancer are associated in the general population.

Cited by 69 publications

References 42 publications

Psychiatric Disorders in Cancer Patients at a University Hospital in Japan: Descriptive Analysis of 765 Psychiatric Referrals

Psychiatric Disorders in Cancer Patients at a University Hospital in Japan: Descriptive Analysis of 765 Psychiatric Referrals

Mood and Anxiety Disorders as Early Manifestations of Medical Illness: A Systematic Review

Investigation of the Incidence of Pancreatic Cancer-Related Depression and Its Relationship with the Quality of Life of Patients

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