Mood and Anxiety Disorders as Early Manifestations of Medical Illness: A Systematic Review

Cosci, Fiammetta; Fava, Giovanni A.; Sonino, Nicoletta

doi:10.1159/000367913

Cited by 88 publications

(50 citation statements)

References 90 publications

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“…There is evidence that psychiatric disturbances in the course of medical disease are substantially different from those that can be found in psychiatric settings in terms of clinical characteristics, response to treatment, and prognosis [116,117]. At times, mood and anxiety disturbances precede the onset of symptoms of a medical condition [117].…”

Section: Psychosomatic Assessment and Individualized Carementioning

confidence: 99%

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Current Psychosomatic Practice

Fava

Cosci²,

Sonino³

2016

Psychother Psychosom

Self Cite

238

317

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Psychosomatic research has advanced over the past decades in dealing with complex biopsychosocial phenomena and may provide new effective modalities of patient care. Among psychosocial variables affecting individual vulnerability, course, and outcome of any medical disease, the role of chronic stress (allostatic load/overload) has emerged as a crucial factor. Assessment strategies include the Diagnostic Criteria for Psychosomatic Research. They are presented here in an updated version based on insights derived from studies carried out so far and encompass allostatic overload, type A behavior, alexithymia, the spectrum of maladaptive illness behavior, demoralization, irritable mood, and somatic symptoms secondary to a psychiatric disorder. Macroanalysis is a helpful tool for identifying the relationships between biological and psychosocial variables and the individual targets for medical intervention. The personalized and holistic approach to the patient includes integration of medical and psychological therapies in all phases of illness. In this respect, the development of a new psychotherapeutic modality, Well-Being Therapy, seems to be promising. The growth of subspecialties, such as psychooncology and psychodermatology, drives towards the multidisciplinary organization of health care to overcome artificial boundaries. There have been major transformations in health care needs in the past decades. From psychosomatic medicine, a land of innovative hypotheses and trends, many indications for changes in the current practice of medicine are now at hand. The aim of this critical review is to outline current and potential clinical applications of psychosomatic methods.

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Section: Psychosomatic Assessment and Individualized Carementioning

confidence: 99%

“…At times, mood and anxiety disturbances precede the onset of symptoms of a medical condition [117]. The potential relationship between medical disorders and psychiatric symptoms ranges from a purely coincidental occurrence to a direct causal role of organic factors.…”

Section: Psychosomatic Assessment and Individualized Carementioning

confidence: 99%

Current Psychosomatic Practice

Fava

Cosci²,

Sonino³

2016

Psychother Psychosom

Self Cite

238

317

View full text Add to dashboard Cite

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“…There is also some accumulating evidence indicating that affective and somatic depressive symptoms may occur prior to the establishment of a cancer diagnosis 22,23 .…”

Section: Epidemiological Links Between Depression and Cancermentioning

confidence: 99%

Depression in cancer: The many biobehavioral pathways driving tumor progression

Bortolato

Hyphantis

Valpione

et al. 2017

Cancer Treatment Reviews

243

179

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Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote:(1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitary-adrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioural pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed.

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“…Normal chest radiography Brain CT scan: hypodense lesion, progressive hydrocephalia in short period mained undiagnosed as to the underlying medical illness (17). These findings show the importance of diagnostic workup of the patients with psychiatric symptoms, particularly when they appear with atypical representations.…”

Section: Radiographic Changesmentioning

confidence: 89%

Serial Polymorphonuclear Predominance of Cerebrospinal Fluid in a Child with Advanced Tuberculous Meningitis: A Case Report

Hosamirudsari

Afsari

Etesam

2017

Iran Red Crescent Med J

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Introduction: Tuberculous meningitis (TBM) is the most fatal form of tuberculosis. Despite adequate treatment, its mortality and morbidity is high. Clinical, laboratory, and radiologic findings help in diagnosis of TBM, although analysis of cerebrospinal fluid (CFS) might sometimes delay and mislead the rapid diagnosis. Case Presentation: We present a 14-year-old Afghan immigrant male, with uncommon laboratory results of advanced TBM, who referred to Baharloo hospial in Tehran, Iran, in September 2016. He experienced headache and anxiety one month prior to referring to the hospital; he had fever, severe headache, vomiting and showed bizarre behavior 7 days before admission. Suspecting meningoencephalitis, the physician advised empirical treatment. The first CSF revealed polymorphonuclear (PMN) predominance with low glucose, which was repeated in the second and third CSF analysis. This pattern indicates early phase of TB meningitis. In day 4, antituberculous treatment with corticosteroid was administered empirically. Unfortunately, he succumbed to disease in day 36. Polymerase chain reaction (PCR) for mycobacterium tuberculosis (MTB) in CSF was positive. The patient's presentation (lethargic to coma) and brain computed tomography (CT) scan indicated advanced stage of disease. Conclusions: All physicians should consider TB meningitis in any patient with low glucose even with serial PMN predominance in CSF.

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Mood and Anxiety Disorders as Early Manifestations of Medical Illness: A Systematic Review

Cited by 88 publications

References 90 publications

Current Psychosomatic Practice

Current Psychosomatic Practice

Depression in cancer: The many biobehavioral pathways driving tumor progression

Serial Polymorphonuclear Predominance of Cerebrospinal Fluid in a Child with Advanced Tuberculous Meningitis: A Case Report

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